scholarly journals Role of the Dorsomedial Hypothalamus in Mediating the Response to Benzodiazepines on Trial 2 in the Elevated Plus-Maze Test of Anxiety

1999 ◽  
Vol 21 (2) ◽  
pp. 312-320 ◽  
Author(s):  
S File
Keyword(s):  
Elevated Plus Maze ◽  
Dorsomedial Hypothalamus ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

Age and sex affect spatial and emotional behaviors in rats: The role of repeated elevated plus maze test

Neuroscience ◽  
2012 ◽  
Vol 227 ◽  
pp. 1-9 ◽  
Author(s):  
M. Belviranli ◽  
K.E.N. Atalik ◽  
N. Okudan ◽  
H. Gökbel
Keyword(s):  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Age And Sex

scholarly journals Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response

2013 ◽  
Vol 25 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Jalal Solati ◽  
Ramin Hajikhani ◽  
Yulia Golub
Keyword(s):  
Prefrontal Cortex ◽  
Receptor Antagonist ◽  
Medial Prefrontal Cortex ◽  
Gabaa Receptors ◽  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

ObjectivesThere has been increasing evidence that the γ-aminobutyric acid (GABA)ergic system is involved in the neurobiology of anxiety. The present study aimed to investigate the role of GABAergic systems in the modulation of anxiety in the medial prefrontal cortex (mPFC) of rats using the elevated plus maze test.MethodsRats were anaesthetised with a mixture of ketamine and xylazine, and then special cannulae were inserted stereotaxically into the mPFC. After 5–7 days of recovery, the effects of intra-mPFC administration of GABAergic agents were studied.ResultsBilateral injection of the GABAA receptor agonist muscimol (0.25, 0.5 and 1 μg/rat) produces an anxiolytic-like effect, shown by significant increases in the percentage of open-arm time (%OAT) and percentage of open-arm entries (%OAE). Intra-mPFC administration of the GABAA receptor antagonist bicuculline (0.25, 0.5 and 1 μg/rat) produces significant anxiogenic-like behaviour. However, intra-mPFC injection of the GABAB receptor agonist baclofen (0.05, 0.1 and 0.2 μg/rat) and the GABAB receptor antagonist CGP35348 (5, 10 and 15 μg/rat) did not alter %OAT and %OAE significantly.ConclusionThe results of the present study demonstrate that the GABAergic system of the mPFC modulates anxiety-related behaviours of rats through GABAA receptors.

The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior

2012 ◽  
Vol 4 (1) ◽  
pp. 98-115 ◽  
Author(s):  
Cornelius R. Pawlak ◽  
Britta D. Karrenbauer ◽  
Peggy Schneider ◽  
Ying-Jui Ho
Keyword(s):  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Motivated Behavior ◽  
Maze Test ◽  
Individual Variations ◽  
Plus Maze ◽  
Unselected Population ◽  
Natural Variance ◽  
Critical Aspects

The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and introduction about the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here.

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