Social Contexts, Agency, and Conflicts: Exploring Critical Aspects of Design for Future Smart Home Technologies

Smart devices are increasingly being designed for, and adopted in, the home environment. Prior scholarship has investigated the challenges that users face as they take up these devices in their homes. However, little is known about when and how users or potential users would prefer future domestic Internet of Things (IoT) to support their activities in home settings. To fill this gap, we conducted two co-design workshops, an in-home activity between the two sessions, and pre- and post-study interviews with 18 adult participants, who had diverse levels of prior experience of IoT use. Our findings contribute new insights into how smart home devices could adapt their behavior based on social contexts; how to re-imagine agency and support useful intelligibility; and how to resolve user-driven conflict by providing appropriate information about those with whom devices are shared. Finally, based on these findings, we discuss the implications of our work and provide a set of design considerations from which designers of future smart home technologies can benefit.

A Survey of Privacy Vulnerabilities of Mobile Device Sensors

The number of mobile devices, such as smartphones and smartwatches, is relentlessly increasing to almost 6.8 billion by 2022, and along with it, the amount of personal and sensitive data captured by them. This survey overviews the state of the art of what personal and sensitive user attributes can be extracted from mobile device sensors, emphasising critical aspects such as demographics, health and body features, activity and behaviour recognition, etc. In addition, we review popular metrics in the literature to quantify the degree of privacy, and discuss powerful privacy methods to protect the sensitive data while preserving data utility for analysis. Finally, open research questions are presented for further advancements in the field.

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

In silico modelling revealed how only three Spike mutations of maVie16 enhanced interaction with murine ACE2. MaVie16 induced profound pathology in BALB/c and C57BL/6 mice and the resulting mouse COVID-19 (mCOVID-19) replicated critical aspects of human disease, including early lymphopenia, pulmonary immune cell infiltration, pneumonia and specific adaptive immunity. Inhibition of the proinflammatory cytokines IFNg and TNF substantially reduced immunopathology. Importantly, genetic ACE2-deficiency completely prevented mCOVID-19 development. Finally, inhalation therapy with recombinant ACE2 fully protected mice from mCOVID-19, revealing a novel and efficient treatment. Thus, we here present maVie16 as a new tool to model COVID-19 for the discovery of new therapies and show that disease severity is determined by cytokine-driven immunopathology and critically dependent on ACE2 in vivo.

Potassium permanganate is an excellent alternative to osmium tetroxide in freeze-substitution

High-pressure freezing followed by freeze-substitution is a valuable method for ultrastructural analyses of resin-embedded biological samples. The visualization of lipid membranes is one of the most critical aspects of any ultrastructural study and can be especially challenging in high-pressure frozen specimens. Historically, osmium tetroxide has been the preferred fixative and staining agent for lipid-containing structures in freeze-substitution solutions. However, osmium tetroxide is not only a rare and expensive material, but also volatile and toxic. Here, we introduce the use of a combination of potassium permanganate, uranyl acetate, and water in acetone as complementing reagents during the freeze-substitution process. This mix imparts an intense en bloc stain to cellular ultrastructure and membranes, which makes poststaining superfluous and is well suited for block-face imaging. Thus, potassium permanganate can effectively replace osmium tetroxide in the freeze-substitution solution without sacrificing the quality of ultrastructural preservation.

Age-based Analysis of the Perceptions of Aging and Successful Aging in Malaysia

Given that ageism could have detrimental effects on the aging society, knowing how people of different age groups perceive aging and successful aging is important. This study collected data from 648 respondents aged between 18 and 80 years old for an age-based analysis of the perceptions toward aging and successful aging. The findings revealed that generally, being healthy, happy, and physically active are considered important aspects of successful aging. Regardless of age, health is perceived as the most fundamental part of life. Both the psychosocial and health factors are critical aspects of successful aging. Hence, it is critical to look into the provision of better healthcare and public facilities for older adults, to find ways to reduce negative attitudes toward older people and to assist older adults to live successfully at old age.

Identifying adoption and usability factors of locator devices for persons living with dementia

A growing number of Canadians live with dementia. Strategies to reduce the risks of getting lost include physical barriers, restraints and medications. However, these strategies can restrict one’s participation in meaningful activities and reduce quality of life. Locator devices can be used to manage safety risks while also supporting engagement and independence among persons living with dementia. As more locator devices become available on the market, adoption rates would be affected by certain factors. There is no clear, standardized approach to identify the factors that have an influence on the acceptance and usability of locator devices for persons with dementia and their care partners. This project aimed to identify factors related to acceptance and usability of locator devices that are important to individuals with dementia, their care partners, service providers and technology developers. Qualitative description and conventional content analysis guided our approach. We conducted 5 focus groups with 21 participants. Trustworthiness strategies included multiple data sources, data verification for accuracy and peer debrief. Five overarching factors emerged as critical aspects in the acceptance and usability of locator devices. These factors were inclusivity, simplicity, features, physical properties and ethics. Participants thought that locator devices do not adequately consider privacy and stigma. Therefore, the acceptance and usability of locator devices could be enhanced if privacy and stigma are addressed. The factors identified will inform the creation of an acceptance and usability scale for locator devices used by persons living with dementia, their care partners and service providers.

Designing and coding with BBC micro:bit to solve a real-world task – a challenging movement between contexts

Designing programmed technological solutions (PTS) with programming materials has become a way to contextualise educational content related to PTS and programming. However, studies show that pupils have difficulties conceptualising central phenomena involved in the process, which affects their ability to design PTS. In order to understand these difficulties, this study investigates pupils’ ways of experiencing the process of solving a real-world task with a programming material. The study takes its point of departure from a previous study that identified two central phenomena, the dual nature (structure and function) of PTS and the BBC micro:bit material, when pupils, aged 10 and 14, were designing a burglar alarm with the BBC micro:bit. The data was revisited with the aim of analysing pupils’ sequential discernment of critical aspects of the phenomena (i.e. aspects necessary to discern in order to understand phenomena), and how this affects how the design process unfolds. The results show that the movement from the real-world context toward the BBC micro:bit context is challenging. Pupils need to be able to connect conditions in the real-world context both to aspects of the dual nature of their PTS, and to aspects of the BBC micro:bit material that represent the dual nature. This suggests the importance of appreciating the BBC micro:bit context and the real-world context in relation to the dual nature of PTS, and of addressing the sequential stages of the process in which aspects of phenomena and their interrelations are emphasised, to help pupils see the PTS in the changing contexts.

Membrane Technological Pathways and Inherent Structure of Bacterial Cellulose Composites for Drug Delivery

This report summarizes efforts undertaken in the area of drug delivery, with a look at further efforts made in the area of bacterial cellulose (BC) biomedical applications in general. There are many current methodologies (past and present) for the creation of BC membrane composites custom-engineered with drug delivery functionality, with brief consideration for very close applications within the broader category of biomedicine. The most emphasis was placed on the crucial aspects that open the door to the possibility of drug delivery or the potential for use as drug carriers. Additionally, consideration has been given to laboratory explorations as well as already established BC-drug delivery systems (DDS) that are either on the market commercially or have been patented in anticipation of future commercialization. The cellulose producing strains, current synthesis and growth pathways, critical aspects and intrinsic morphological features of BC were given maximum consideration, among other crucial aspects of BC DDS.

An Overview of Low Vision Aids

Low vision is something that will cause hindrance in one’s daily activities. These problems are on the rise amongst the Indian population nowadays. Low vision is one of the emerging problems which needs immediate attention. Blindness is one of the most critical aspects of low vision. In a survey conducted at the national level in 1989-90, approximately 12 million people of India accounted for about 1.5% who were blind presented with a visual acuity of about <6/60 in the eye with better vision. Visual impairment possesses a financial burden, which is why we cannot pay attention to it . Funding by the government in this sector should be the thing which should be taken care of. The rehabilitative purpose of low aids is to help people perform their daily chores without any disturbances. Low vision aids are different depending on different age groups of the population. Spectacles are commonly used measures to correct low vision, but they are not socially acceptable. There is a stigma still associated with spectacles, so the person wearing them feels insecure about it. Low vision is not always necessarily associated with any disease of the eye. Negligence associated with low vision causes an increase in the number of blind cases overall. Depending upon the type of visual loss, appropriate corrective measures can be brought into force. In the current scenario, covid-19 is also one of the leading causes of the growing number of eye diseases globally due to the online platforms used.