scholarly journals B021 Nocturnal blood pressure fall correlates positively with plasma renin activity in hypertensives

1998 ◽  
Vol 11 (4) ◽  
pp. 45A
Author(s):  
L MATAVELLI
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Fall ◽  
Pressure Fall

Effects of the Oral Angiotensin-Converting Enzyme Inhibitor MK-421 in Human Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 281s-283s ◽  
Author(s):  
H. Gavras ◽  
J. Biollaz ◽  
B. Waeber ◽  
H. R. Brunner ◽  
Gavras Irene ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Plasma Renin Activity ◽  
Enzyme Inhibitor ◽  
Plasma Renin ◽  
Pressure Control ◽  
Renin Activity ◽  
Converting Enzyme ◽  
Blood Pressure Fall ◽  
Plasma Angiotensin

1. The effects of the new oral angiotensin-converting enzyme (ACE) inhibitor MK-421 on blood pressure, plasma renin activity, angiotensin II, aldosterone and converting enzyme activity were assessed in 16 hypertensive patients followed for 6–18 weeks. 2. After an initial titration period, maintenance doses of 2.5–40 mg once daily produced satisfactory blood pressure control in 11 and a partial but significant decrease in the remainder. 3. Treatment was associated with no change in heart rate and no orthostatic hypotension. At 24 h after the first effective dose, blood pressure was still decreased, plasma ACE was suppressed to 16% of the baseline, plasma angiotensin to 58%, aldosterone to 42%, and plasma renin activity was elevated to 228% of the baseline. 4. Magnitude of blood pressure fall was significantly correlated with the height of pretreatment blood pressure but not with baseline levels of plasma renin activity.

Nocturnal Blood Pressure Fall on Ambulatory Monitoring in a Large International Database

Hypertension ◽  
1997 ◽  
Vol 29 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Jan A. Staessen ◽  
Leszek Bieniaszewski ◽  
Eoin O'Brien ◽  
Philippe Gosse ◽  
Hiroshi Hayashi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ambulatory Monitoring ◽  
International Database ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Fall ◽  
Pressure Fall

[PP.16.12] THE PERSONALIZED NOCTURNAL BLOOD PRESSURE FALL IS NECESSARY TO DETERMINE THE ASSOCIATION BETWEEN VASCULAR DAMAGE AND BP DIPPING

2017 ◽  
Vol 35 ◽  
pp. e220-e221
Author(s):  
P. Nazzaro ◽  
G. Schirosi ◽  
L. De Benedittis ◽  
F. Caradonna-Moscatelli ◽  
M. Contini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Damage ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Fall ◽  
Pressure Fall

Enhancement of the Antihypertensive Effect of Hydrochlorothiazide in Dogs after Suppression of Renin Release by Beta-Adrenergic Blockade

1975 ◽  
Vol 48 (2) ◽  
pp. 147-151
Author(s):  
C. S. Sweet ◽  
M. Mandradjieff
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Arterial Blood Pressure ◽  
Antihypertensive Effect ◽  
Plasma Renin ◽  
Renin Activity ◽  
Renin Release ◽  
Antihypertensive Activity ◽  
Adrenergic Blockade ◽  
Arterial Blood

1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure and plasma renin activity were measured over the treatment period. 2. Neither drug significantly lowered arterial blood pressure when administered alone. Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. 3. When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. 4. These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.

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