Platelet counts in depressed patients treated with amitriptyline or paroxetine

2003 ◽  
Vol 18 (2) ◽  
pp. 89-91 ◽  
Author(s):  
F. Lederbogen ◽  
E. Hörer ◽  
R. Hellweg ◽  
I. Heuser ◽  
M. Deuschle
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Major Depressive ◽  
Thromboembolic Risk ◽  
Platelet Counts ◽  
Depressed Patients ◽  
Standardized Treatment ◽  
Dsm Iv

AbstractObjectiveTo assess whether therapy with two widely used antidepressants influences platelet counts.Subjects and methodsIn 90 patients hospitalized for treatment of a major depressive episode according to DSM-IV, platelet counts were performed after a 6 d antidepressant-free run-in period and again after 35 d of active standardized treatment with amitriptyline (n = 40) or paroxetine (n = 50).ResultsThere was a trend for platelet counts to increase during treatment with amitriptyline (from 245.5 ± 68.6 to 256.8 ± 69 cells × 109 L-1, P < 0.06); no change was observed during treatment with paroxetine (from 232.6 ± 58.3 to 234.6 ± 68.9 cells × 109 L-1, n.s).ConclusionsTreatment with amitriptyline tends to be associated with elevated platelet counts. The cause for this increase is not known, but may be relevant in terms of patients’ long-term thromboembolic risk.

Empirical Investigation of Two Assumptions in the Diagnosis of DSM-IV Major Depressive Episode

2007 ◽  
Vol 41 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Chika Sakashita ◽  
Tim Slade ◽  
Gavin Andrews
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Sleep Problems ◽  
Composite International Diagnostic Interview ◽  
Population Based ◽  
Diagnostic Interview ◽  
Major Depressive ◽  
Diagnostic Threshold ◽  
Dsm Iv ◽  
The Relationship

Objective: The aim of the current study was to examine two major assumptions behind the DSM-IV diagnosis of major depressive episode (MDE): that depression represents a distinct category defined by a valid symptom threshold, and that each depressive symptom contributes equally to the diagnosis. Methods: Data were from the Australian National Survey of Mental Health and Wellbeing. Participants consisted of a random population-based sample of 10 641 community volunteers, representing a response rate of 78%. DSM-IV diagnoses of MDE and other mental disorders were obtained using the Composite International Diagnostic Interview, version 2.0. Analyses were carried out on the subsample of respondents who endorsed either depressed mood or loss of interest (n =2137). Multivariate linear regression analyses examined the relationship between the number and type of symptoms and four independent measures of impairment. Results: The relationship between the number of depressive symptoms and the four measures of impairment was purely linear. Three individual symptoms (sleep problems, energy loss, and psychomotor disturbance) were all independent predictors of three of the four measures of impairment. Conclusions: Counting symptoms alone is limited in guiding a clear diagnostic threshold. The differential impact of individual symptoms on impairment suggests that impairment levels may be more accurately estimated by weighting the particular symptoms endorsed.

Is DSM-IV Bereavement Exclusion for Major Depressive Episode Relevant to Severity and Pattern of Symptoms?

2009 ◽  
Vol 70 (8) ◽  
pp. 1091-1097 ◽  
Author(s):  
Emmanuelle Corruble ◽  
Virginie-Anne Chouinard ◽  
Alexia Letierce ◽  
Philip A. P. M. Gorwood ◽  
Guy Chouinard
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Major Depressive ◽  
Dsm Iv

Urinary monoamines and monoamine metabolites in subtypes of unipolar depressive disorder and normal controls

1986 ◽  
Vol 16 (3) ◽  
pp. 541-546 ◽  
Author(s):  
Alec Roy ◽  
David Pickar ◽  
Patrice Douillet ◽  
Farouk Karoum ◽  
Markku Linnoila
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Dysthymic Disorder ◽  
Monoamine Metabolites ◽  
Urinary Catecholamine ◽  
Major Depressive ◽  
Depressed Patients ◽  
Sympathetic Nervous ◽  
Normal Controls ◽  
Lower Urinary

SynopsisAn examination was made of urinary catecholamine and metabolite outputs in 28 unipolar depressed patients and 25 normal controls. The total group of depressed patients had significantly higher urinary outputs of norepinephrine (NE) and its metabolite normetanephrine (NM), and significantly lower urinary outputs of the dopamine metabolite dihydroxyphenylacetic acid (DOPAC), than controls. Patients who met DSM-III criteria for a major depressive episode with melancholia (N = 8) had significantly higher urinary outputs of normetanephrine than controls, whereas patients with a major depressive episode without melancholia (N = 7) and dysthymic disorder patients (N = 8) had levels comparable with controls. We postulate that the higher urinary outputs of norepinephrine and its metabolite, normetanephrine, reflect dysregulation of the sympathetic nervous system in depression.

Mean Beck Depression Inventory–II Scores by Severity of Major Depressive Episode

2001 ◽  
Vol 88 (3_suppl) ◽  
pp. 1075-1076 ◽  
Author(s):  
Robert A. Steer ◽  
Gregory K. Brown ◽  
Aaron T. Beck ◽  
William C. Sanderson
Keyword(s):  
Beck Depression Inventory ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Major Depressive ◽  
Dsm Iv ◽  
The Mean

The Beck Depression Inventory–II total scores of 35 (14%) outpatients who were diagnosed with a mild DSM–IV Major Depressive Episode (MDE), 144 (55%) outpatients with a moderate MDE, and 81 (31%) outpatients with a severe MDE were compared. The mean BDI–II total scores were, respectively, 18 ( SD = 8, 99% CI 12–23), 27 ( SD = 10, 99% CI 24–29), and 34 ( SD = 10, 99% CI 30–37) ( F2,257 = 33.25, p < .001). The mean BDI–II total score of the outpatients with a severe specifier was significantly higher than the mean BDI–II total score of the outpatients with a moderate specifier which was, in turn, significantly higher than the mean BDI–II total score of the outpatients with a mild specifier.

Responses to depression in unipolar depressed patients: an investigation of Nolen-Hoeksema's response styles theory

1999 ◽  
Vol 29 (6) ◽  
pp. 1323-1333 ◽  
Author(s):  
CHRISTINE KUEHNER ◽  
IRIS WEBER
Keyword(s):  
Gender Differences ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Empirical Support ◽  
Response Styles ◽  
Post Discharge ◽  
Major Depressive ◽  
Depressed Patients ◽  
Response Styles Theory

Background. The response styles theory suggests that rumination in response to depressed mood exacerbates and prolongs depression, while distraction ameliorates and shortens it. Gender differences in response styles are said to contribute to the observed gender differences in the prevalence of unipolar depression. While empirical support for the theory has been found from a variety of non-clinical studies, its generalizability to clinically depressed patient populations remains unclear.Methods. A cohort of 52 unipolar depressed in-patients was assessed with the Response Styles Questionnaire during in-patient stay (T1) and 4 weeks after discharge (T2). The patients were followed up 4 months after discharge (T3). Clinical assessment included the SCAN-PSE-10.Results. Moderate and statistically significant retest-stabilities for rumination and distraction were found, comparable for patients with stable and changing depression status from T1 to T2. A cross-sectional diagnosis of a major depressive episode was associated with rumination, while gender was not. Post-discharge baseline rumination (T2), adjusted for concurrent depression, predicted follow-up levels of depression (T3), and, in patients who were non-remitted at post-discharge baseline, it predicted presence of a major depressive episode at follow-up (T3). Results on distraction were more ambiguous.Conclusions. Our results suggest that rumination is likely to have a deteriorating impact on the course of clinical episodes of depression in unipolar depressed patients. Larger longitudinal patient studies are needed to validate these findings.

Long-Term Administration of Tianeptine in Depressed Patients after Alcohol Withdrawal

1992 ◽  
Vol 160 (S15) ◽  
pp. 66-71 ◽  
Author(s):  
R. Malka ◽  
H. Lôo ◽  
H. Ganry ◽  
A. Souche ◽  
C. Marey ◽  
...  
Keyword(s):  
Side Effects ◽  
Alcohol Withdrawal ◽  
Major Depressive Episode ◽  
Multicentre Trial ◽  
Dysthymic Disorder ◽  
Major Depressive ◽  
Depressed Patients ◽  
Term Administration ◽  
Neurochemical Effect

Alcohol interferes with the central metabolism of the catecholamines and especially with indolamines (5-HT). Thus, the use of an antidepressant such as tianeptine, whose main neurochemical effect is to increase the reuptake of 5-HT, seems to be particularly indicated for the continued treatment of depressed patients after alcohol withdrawal. This study evaluated the therapeutic efficacy and acceptability during long-term administration of tianeptine in depressed patients (major depressive episode or dysthymic disorder) in a multicentre trial, after withdrawal from alcohol abuse or dependence. The results relate to 130 depressed patients, who abstained from alcohol and received treatment for a year. Only one patient dropped-out because of side-effects, and medication was interrupted in 5% of subjects because of alcoholic relapses. Prescribed in the long term, tianeptine did not produce orthostatic hypotension, changes in bodyweight, or alterations in the ECG. All changes found in haematological and biochemical investigations suggested an improvement in patients' physical state. This, and other studies, indicate that tianeptine appears to have the potential to be a safe antidepressant, which might be particularly useful in those patients who are susceptible to the side-effects of psychotropic drugs.

Suicide behavior and subthreshold psychiatric disorders among children and adolescents

2011 ◽  
Vol 26 (S2) ◽  
pp. 265-265
Author(s):  
J. Balazs ◽  
G. Dallos ◽  
A. Kereszteny ◽  
J. Gadoros
Keyword(s):  
Psychiatric Disorders ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Hospitalized Children ◽  
Major Depressive ◽  
Psychiatric Illnesses ◽  
Suicide Behavior ◽  
Child Psychiatric ◽  
Report Data ◽  
Dsm Iv

ObjectiveSuicide among adults have been associated to subthreshold psychiatric illnesses as well; however it is little known about the role of subthreshold mental disorders in suicide risk among children/adolescents.MethodsUsing the Mini International Neuropsychiatric Interview Kid the authors examined 105 hospitalized children/adolescents in the Vadaskert Child Psychiatric Hospital, Budapest. Current suicide behavior was defined as giving positive answer to any of the following questions: “In the past month did you: think you would be better off dead or wish you were dead? want to hurt yourself? think about killing yourself? attempt suicide?”ResultsWe report data on 105 hospitalized children/adolescents, 76 (72.4%) boys and 29 (27.6%) girls. The mean age of the subjects was 11.4 years (SD = 3.43, min: 5, max: 17). Current suicide behavior was present in 18 cases (17.1%). There were one person with current suicide behavior, who did not have any current DSM-IV disorder, but he/she had current subthreshold disorder. The majority (n = 16, 88.8%) of the children/adolescents with suicide behavior had both current subthreshold and DSM-IV disorders. Eight children/adolescents (44.4%) with current suicide behavior had current DSM-IV major depressive episode and further 5 children/adolescents (27,8%) had current subthreshold major depressive episode. The prevalence of DSM-IV and subthreshold major depressive episode was significantly higher among hospitalized children with suicide behavior (n = 18), than among hospitalized children without suicide behavior (n = 87) (X2 = 5,272, df = 1. p = 0,022).ConclusionsSubthreshold forms of pediatric psychiatric disorders need to be taken into account as well in suicide prevention.

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