P.1.g.064 Stimulation of the dorsal raphe nucleus lateral wings activates neural structures involved in the modulation of panic-like defensive behaviours

2015 ◽  
Vol 25 ◽  
pp. S271
Author(s):  
M. Matthiesen ◽  
A. Spiacci ◽  
H. Zangrossi
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Defensive Behaviours ◽  
Dorsal Raphé ◽  
Stimulation Of

Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways

2013 ◽  
Vol 67 ◽  
pp. 379-394 ◽  
Author(s):  
Audrey Francisco Biagioni ◽  
Renato Leonardo de Freitas ◽  
Juliana Almeida da Silva ◽  
Rithiele Cristina de Oliveira ◽  
Ricardo de Oliveira ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsomedial Hypothalamus ◽  
Defensive Behaviours ◽  
Dorsal Raphé

scholarly journals Differential Effects of Electrical Stimulation of the Dorsal Raphe Nucleus and of Cervical Sympathectomy on Serotonin and Noradrenaline Concentrations in Major Cerebral Arteries and Pial Vessels in the Rat

1990 ◽  
Vol 10 (1) ◽  
pp. 123-126 ◽  
Author(s):  
G. Bonvento ◽  
P. Lacombe ◽  
E. T. MacKenzie ◽  
L. Rouquier ◽  
B. Scatton ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Dorsal Raphe Nucleus ◽  
Cerebral Arteries ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Cervical Sympathectomy ◽  
Large Arteries ◽  
Pial Vessels ◽  
Dorsal Raphé ◽  
Stimulation Of

The levels of noradrenaline (NA), serotonin (5-HT), and 5-hydroxyindoleacetic acid were measured by HPLC and compared between the large arteries of the circle of Willis and the small pial vessels in the rat, following either electrical stimulation of the dorsal raphe nucleus or bilateral superior cervical ganglionectomy. With electrical stimulation, the 5-HT concentrations were reduced (– 48%) in the small pial vessels, but were unchanged in the major cerebral arteries. NA concentrations were dramatically reduced following cervical sympathectomy in the large arteries (– 77%), though the reduction was less pronounced (– 34%) in the small vessels. Sympathectomy caused a significant decrease in the 5-HT concentration of the major cerebral arteries (–33%), but was without effect on the 5-HT levels of the small pial vessels. These results show that an appreciable fraction of the perivascular 5-HT measured in the small pial and the large cerebral arteries originates from different sources.

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