Effects of Ketanserin on the Discrimination of Electrical Stimulation of the Dorsal Raphé Nucleus in Rats * *Presented in part at the Society for Neuroscience Meeting, Miami Beach, 1994 (Mokler et al., 1994b).

1997 ◽  
Vol 36 (4-5) ◽  
pp. 631-636 ◽  
Author(s):  
D.J MOKLER ◽  
S ABBRUZZESE ◽  
V TRUMBLE ◽  
B WHITTEN
Keyword(s):  
Electrical Stimulation ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé ◽  
Stimulation Of

scholarly journals Differential Effects of Electrical Stimulation of the Dorsal Raphe Nucleus and of Cervical Sympathectomy on Serotonin and Noradrenaline Concentrations in Major Cerebral Arteries and Pial Vessels in the Rat

1990 ◽  
Vol 10 (1) ◽  
pp. 123-126 ◽  
Author(s):  
G. Bonvento ◽  
P. Lacombe ◽  
E. T. MacKenzie ◽  
L. Rouquier ◽  
B. Scatton ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Dorsal Raphe Nucleus ◽  
Cerebral Arteries ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Cervical Sympathectomy ◽  
Large Arteries ◽  
Pial Vessels ◽  
Dorsal Raphé ◽  
Stimulation Of

The levels of noradrenaline (NA), serotonin (5-HT), and 5-hydroxyindoleacetic acid were measured by HPLC and compared between the large arteries of the circle of Willis and the small pial vessels in the rat, following either electrical stimulation of the dorsal raphe nucleus or bilateral superior cervical ganglionectomy. With electrical stimulation, the 5-HT concentrations were reduced (– 48%) in the small pial vessels, but were unchanged in the major cerebral arteries. NA concentrations were dramatically reduced following cervical sympathectomy in the large arteries (– 77%), though the reduction was less pronounced (– 34%) in the small vessels. Sympathectomy caused a significant decrease in the 5-HT concentration of the major cerebral arteries (–33%), but was without effect on the 5-HT levels of the small pial vessels. These results show that an appreciable fraction of the perivascular 5-HT measured in the small pial and the large cerebral arteries originates from different sources.

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