In vivo estimation of calcium phosphate cements containing chondroitin sulfate in subcutis

The management and treatment of dental and craniofacial injuries have continued to evolve throughout the last several decades. Limitations with autograft, allograft, and synthetics created the need for more advanced approaches in tissue engineering. Calcium phosphate cements (CPC) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. This review focuses on the up-to-date performance of calcium phosphate cement (CPC) scaffolds and upcoming promising dental and craniofacial bone regeneration strategies. First, we summarized the barriers encountered in CPC scaffold development. Second, we compiled the most up to date in vitro and in vivo literature. Then, we conducted a systematic search of scientific articles in MEDLINE and EMBASE to screen the related studies. Lastly, we revealed the current developments to effectively design CPC scaffolds and track the enhanced viability and therapeutic efficacy to overcome the current limitations and upcoming perspectives. Finally, we presented a timely and opportune review article focusing on the significant potential of CPC scaffolds for dental and craniofacial bone regeneration, which will be discussed thoroughly. CPC offers multiple capabilities that may be considered toward the oral defects, expecting a future outlook in nanotechnology design and performance.

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Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes

Acta Biomaterialia ◽

10.1016/j.actbio.2008.04.023 ◽

2008 ◽

Vol 4 (6) ◽

pp. 1924-1933 ◽

Cited By ~ 57

Author(s):

E.S. Sanzana ◽

M. Navarro ◽

F. Macule ◽

S. Suso ◽

J.A. Planell ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Substitutes ◽

Calcium Phosphate Cements

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Comparative Study on Bioresorbability of Chelate-Setting Cements with Various Calcium-Phosphate Phase Using Rabbit Model

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.529-530.167 ◽

2012 ◽

Vol 529-530 ◽

pp. 167-172 ◽

Cited By ~ 1

Author(s):

Toshiisa Konishi ◽

Shuhei Takahashi ◽

Minori Mizumoto ◽

Michiyo Honda ◽

Koki Kida ◽

...

Keyword(s):

Calcium Phosphate ◽

Inositol Phosphate ◽

Rabbit Model ◽

The Novel ◽

Calcium Phosphate Cements ◽

Phosphate Phase ◽

Setting Mechanism ◽

Calcium Phosphate Phase

We have developed novel calcium-phosphate cements (CPCs) based on the chelate-setting mechanism of inositol phosphate (IP6) using hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and α-TCP as starting materials. These cements (IP6-HAp, IP6-β-TCP and IP6-α-TCP cements) have different bioresorbability due to the chemical composition of starting materials. In the present study, biocompatibility and bioresorbability of the above three cements and commercially available cement (Biopex®-R) was histologically evaluated in vivo using rabbit model for 4, 8, and 24 weeks, in addition to their dissolution in vitro. The dissolution of these cements increased in the order of IP6-HAp, IP6-β-TCP and IP6-α-TCP cements. The newly-formed bones were directly in contact with both the IP6-HAp and Biopex®-R cement specimens. As for the IP6-β-TCP and IP6-α-TCP cements, newly-formed bones were formed time-dependently slightly apart from the cement specimens. Resorption rate for Biopex®-R, IP6-HAp, IP6-β-TCP, and IP6-α-TCP cements after 24 weeks implantation were of 7.2, 5.0, 13.7, and 16.2%, respectively, compared to original cements. The present chelate-setting cements with different bioresorbability are promising candidates for application as the novel CPCs.

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