2 Mechanisms of action of low molecular weight heparins and heparinoids

1990 ◽  
Vol 3 (3) ◽  
pp. 505-529 ◽  
Author(s):  
F.A. Ofosu ◽  
T.W. Barrowcliffe
Keyword(s):  
Molecular Weight ◽  
Mechanisms Of Action ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins

Heparin and low-molecular-weight heparin

2008 ◽  
Vol 99 (11) ◽  
pp. 807-818 ◽  
Author(s):  
Barbara Mulloy ◽  
Trevor Barrowcliffe ◽  
Elaine Gray
Keyword(s):  
Molecular Weight ◽  
Venous Thrombosis ◽  
Unfractionated Heparin ◽  
Low Molecular Weight Heparin ◽  
Clinical Status ◽  
Mechanisms Of Action ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Prevention And Treatment

SummaryHeparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been shown to be at least as effective and safe as unfractionated heparin and have replaced the latter in many indications. In this article the chemistry, mechanisms of action, measurement of anticoagulant activities, and clinical status of heparin and LMWH are reviewed.

A Perspective on Low Molecular Weight Heparins in the Management of Thrombosis

1993 ◽  
Vol 13 (S 01) ◽  
pp. S5-S11 ◽  
Author(s):  
Debra Hoppensteadt ◽  
Jeanine Walenga ◽  
A Ahsan ◽  
O Iqbal ◽  
W Jeske ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mechanism Of Action ◽  
Manufacturing Process ◽  
Laboratory Tests ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Pharmacological Management

SummaryThe introduction of low molecular weight heparins has added a new dimension to the pharmacological management of thrombotic disorders. Because of different chemical and pharmacological characteristics, due to the manufacturing process, each LMWH should be considered as a distinct entitity and only be used for its given indication. A list of commercially available LMWHs is included. The mechanism of action of the LMWHs and their use in various disorders are discussed. Available laboratory tests for monitoring LMWHs are presented and their limitations pointed out.

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