9013 POSTER DISCUSSION Phase I Dose-escalation Study of AXL1717: a Novel Targeted Oral Insulin-like Growth Factor-1 Receptor (IGF-1R) Inhibitor and Its Implications for Patients With Non-small Cell Lung Carcinoma

2011 ◽  
Vol 47 ◽  
pp. S595-S596 ◽  
Author(s):  
S. Ekman ◽  
J. Harmenberg ◽  
B. Stáhl ◽  
A. Hedlund ◽  
S. Bergström ◽  
...  
Keyword(s):  
Growth Factor ◽  
Phase I ◽  
Lung Carcinoma ◽  
Dose Escalation ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Oral Insulin ◽  
Small Cell Lung ◽  
Dose Escalation Study ◽  
Cell Lung Carcinoma

scholarly journals Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma

2000 ◽  
Vol 25 (1) ◽  
pp. 121-128 ◽  
Author(s):  
MP Rounseville ◽  
TP Davis
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Prohormone Convertase ◽  
Small Cell Lung ◽  
Autocrine Growth ◽  
Cell Lung Carcinoma ◽  
Autocrine Growth Factor

A hallmark of small cell lung carcinoma (SCLC) is the expression of autocrine growth factors such as neurotensin and gastrin-releasing peptide, which bind to cellular receptors and stimulate cell division. The biological activity of autocrine growth factors requires the concurrent expression of prohormone convertases that cleave the growth factors to their active form, suggesting the expression of these genes is linked in SCLCs. RNase protection assays were used to detect the expression of autocrine growth factor and prohormone convertase mRNAs in a panel of lung cancer cell lines. These mRNAs are coexpressed in SCLC and lung carcinoid cell lines, but not in normal lung epithelium or in non-small cell lung cancers. These findings, together with earlier results from our laboratory, suggest the expression of prohormone convertases has an important role in the development and maintenance of the SCLC phenotype and that autocrine growth factor and prohormone convertase genes respond to a common transcriptional activator in SCLC.

Sign in / Sign up

Export Citation Format

Share Document