Random mutagenesis of human estrogen receptor ligand binding domain identifies mutations that decrease sensitivity to estradiol and increase sensitivity to a diphenol indene-ol compound: Basis for a regulatable expression system

1998 ◽  
Vol 64 (3-4) ◽  
pp. 129-135 ◽  
Author(s):  
Nicholas Miller ◽  
James Whelan
Keyword(s):  
Estrogen Receptor ◽  
Ligand Binding ◽  
Expression System ◽  
Random Mutagenesis ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Human Estrogen Receptor ◽  
Estrogen Receptor Ligand

Simulations of the Estrogen Receptor Ligand-Binding Domain:  Affinity of Natural Ligands and Xenoestrogens

2000 ◽  
Vol 43 (24) ◽  
pp. 4594-4605 ◽  
Author(s):  
B. Chris Oostenbrink ◽  
Jed W. Pitera ◽  
Marola M. H. van Lipzig ◽  
John H. N. Meerman ◽  
Wilfred F. van Gunsteren
Keyword(s):  
Estrogen Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Natural Ligands ◽  
Estrogen Receptor Ligand

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain

ChemBioChem ◽  
2010 ◽  
Vol 11 (16) ◽  
pp. 2251-2254 ◽  
Author(s):  
Sabine Möcklinghoff ◽  
Rolf Rose ◽  
Maëlle Carraz ◽  
Arie Visser ◽  
Christian Ottmann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Estrogen Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Synthesis And Crystal Structure ◽  
Estrogen Receptor Ligand

scholarly journals Mutations in the Estrogen Receptor Ligand Binding Domain Discriminate between Hormone-dependent Transactivation and Transrepression

2000 ◽  
Vol 275 (33) ◽  
pp. 25322-25329 ◽  
Author(s):  
Janet E. Valentine ◽  
Eric Kalkhoven ◽  
Roger White ◽  
Sue Hoare ◽  
Malcolm G. Parker
Keyword(s):  
Estrogen Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Estrogen Receptor Ligand
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