Effects of state and trait emotion on cognitive control: fMRI evidence for selective interactions in dorsolateral prefrontal and anterior cingulate cortex

SUMMARYIn primates, both the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC) are key regions of the frontoparietal cognitive control network. To study the role of the dACC and its communication with the dlPFC in cognitive control, we recorded the local field potentials from the dlPFC before and during the reversible deactivation of the dACC, in macaque monkeys engaging in uncued switches between two stimulus-response rules. Cryogenic dACC deactivation impaired response accuracy during rule-maintenance, but not rule-switching, which coincided with a reduction in the correct-error difference in dlPFC beta activities specifically during maintenance of the more challenging rule. During both rule switching and maintenance, dACC deactivation prolonged the animals’ reaction time and reduced task-related theta/alpha activities in the dlPFC; it also weakened dlPFC theta-gamma phase-amplitude modulation. Thus, the dACC and its interaction with the dlPFC plays a critical role in the maintenance of a new, challenging rule.

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Dissociating the Role of the Dorsolateral Prefrontal and Anterior Cingulate Cortex in Cognitive Control

Science ◽

10.1126/science.288.5472.1835 ◽

2000 ◽

Vol 288 (5472) ◽

pp. 1835-1838 ◽

Cited By ~ 2258

Author(s):

A. W. MacDonald

Keyword(s):

Cognitive Control ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Dorsolateral Prefrontal

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Faculty Opinions recommendation of Is anterior cingulate cortex necessary for cognitive control?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024322.288758 ◽

2005 ◽

Author(s):

Russell Poldrack

Keyword(s):

Cognitive Control ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate

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Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements

Journal of Neurophysiology ◽

10.1152/jn.00626.2013 ◽

2014 ◽

Vol 111 (4) ◽

pp. 787-803 ◽

Cited By ~ 12

Author(s):

Michael J. Koval ◽

R. Matthew Hutchison ◽

Stephen G. Lomber ◽

Stefan Everling

Keyword(s):

Prefrontal Cortex ◽

Eye Movements ◽

Functional Connectivity ◽

Anterior Cingulate Cortex ◽

Dorsolateral Prefrontal Cortex ◽

Saccadic Eye Movements ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Dorsolateral Prefrontal ◽

Single Neuron Recording

The dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC) have both been implicated in the cognitive control of saccadic eye movements by single neuron recording studies in nonhuman primates and functional imaging studies in humans, but their relative roles remain unclear. Here, we reversibly deactivated either dlPFC or ACC subregions in macaque monkeys while the animals performed randomly interleaved pro- and antisaccades. In addition, we explored the whole-brain functional connectivity of these two regions by applying a seed-based resting-state functional MRI analysis in a separate cohort of monkeys. We found that unilateral dlPFC deactivation had stronger behavioral effects on saccades than unilateral ACC deactivation, and that the dlPFC displayed stronger functional connectivity with frontoparietal areas than the ACC. We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC.

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