Heterogeneity and Functional Properties of Subtypes of Sodium-Dependent Glutamate Transporters in the Mammalian Central Nervous System

1996 ◽  
pp. 69-115 ◽  
Author(s):  
Michael B. Robinson ◽  
Lisa A. Dowd
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Properties ◽  
Glutamate Transporters ◽  
Mammalian Central Nervous System ◽  
Sodium Dependent

scholarly journals Glutamate transporters: a broad review of the most recent archaeal and human structures

2019 ◽  
Vol 47 (4) ◽  
pp. 1197-1207 ◽  
Author(s):  
Ana Pavić ◽  
Alexandra O. M. Holmes ◽  
Vincent L. G. Postis ◽  
Adrian Goldman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Design ◽  
Transport Mechanism ◽  
Glutamate Transporters ◽  
Chloride Conductance ◽  
Glutamate Excitotoxicity ◽  
Direct Role ◽  
Mammalian Central Nervous System ◽  
Transport Cycle

Abstract Glutamate transporters play important roles in bacteria, archaea and eukaryotes. Their function in the mammalian central nervous system is essential for preventing excitotoxicity, and their dysregulation is implicated in many diseases, such as epilepsy and Alzheimer's. Elucidating their transport mechanism would further the understanding of these transporters and promote drug design as they provide compelling targets for understanding the pathophysiology of diseases and may have a direct role in the treatment of conditions involving glutamate excitotoxicity. This review outlines the insights into the transport cycle, uncoupled chloride conductance and modulation, as well as identifying areas that require further investigation.

Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous System

Excitotoxins ◽  
1983 ◽  
pp. 43-54 ◽  
Author(s):  
J. Davies ◽  
R. H. Evans ◽  
A. W. Jones ◽  
K. N. Mewett ◽  
D. A. S. Smith ◽  
...  
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Excitatory Amino Acids ◽  
Mammalian Central Nervous System ◽  
Recent Advances
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