Characterization of mRNA for Prostaglandin (PG) E receptor subtypes in ovine fetal Hippocampus (HC), Hypothalamus (HT) Pituitary (P) Gland and Adrenal (ADR) (HHPA) at term

1998 ◽  
Vol 5 (1) ◽  
pp. 154A-154A
Author(s):  
X MA ◽  
W WU ◽  
P NATHANIELSZ
Keyword(s):  
Receptor Subtypes ◽  
Ovine Fetal

In Vivo Characterization of Muscarinic Receptor Subtypes That Mediate Vasodilatation in Patients With Essential Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Tobias A. Bruning ◽  
Peter C. Chang ◽  
Maarten G.C. Hendriks ◽  
Pieter Vermeij ◽  
Martin Pfaffendorf ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
In Vivo Characterization

Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells

1997 ◽  
Vol 357 (1) ◽  
pp. 1-9 ◽  
Author(s):  
K.-N. Klotz ◽  
J. Hessling ◽  
J. Hegler ◽  
C. Owman ◽  
B. Kull ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Cho Cells ◽  
Receptor Subtypes

Functional Characterization of GABAA Receptors in Neonatal Hypothalamic Brain Slice

2002 ◽  
Vol 88 (4) ◽  
pp. 1655-1663 ◽  
Author(s):  
Ren-Qi Huang ◽  
Glenn H. Dillon
Keyword(s):  
Functional Characterization ◽  
Minor Component ◽  
Dehydroepiandrosterone Sulfate ◽  
Receptor Subtypes ◽  
Hypothalamic Neurons ◽  
Inhibitory Neurotransmitter ◽  
Old Rats ◽  
A Minor ◽  
Whole Cell Recordings

The hypothalamus influences a number of autonomic functions. The activity of hypothalamic neurons is modulated in part by release of the inhibitory neurotransmitter GABA onto these neurons. GABAA receptors are formed from a number of distinct subunits, designated α, β, γ, δ, ε, and θ, many of which have multiple isoforms. Little data exist, however, on the functional characteristics of the GABAA receptors present on hypothalamic neurons. To gain insight into which GABAA receptor subunits are functionally expressed in the hypothalamus, we used an array of pharmacologic assessments. Whole cell recordings were made from thin hypothalamic slices obtained from 1- to 14-day-old rats. GABAA receptor-mediated currents were detected in all neurons tested and had an average EC50 of 20 ± 1.6 μM. Hypothalamic GABAA receptors were modulated by diazepam (EC50 = 0.060 μM), zolpidem (EC50 = 0.19 μM), loreclezole (EC50 = 4.4 μM), methyl-6,7-dimethoxy-4-ethyl-β-carboline (EC50= 7.7 μM), and 5α-pregnan-3α-hydroxy-20-one (3α-OH-DHP). Conversely, these receptors were inhibited by Zn2+ (IC50 = 70.5 μM), dehydroepiandrosterone sulfate (IC50 = 16.7 μM), and picrotoxin (IC50 = 2.6 μM). The α4/6-selective antagonist furosemide (10–1,000 μM) was ineffective in all hypothalamic neurons tested. The results of our pharmacological analysis suggest that hypothalamic neurons express functional GABAA receptor subtypes that incorporate α1 and/or α2 subunits, β2 and/or β3 subunits, and the γ2 subunit. Our results suggest receptors expressing α3–α6, β1, γ1, and δ, if present, represent a minor component of functional hypothalamic GABAA receptors.

Characterization of PGE2 receptor subtypes in human eosinophils

2002 ◽  
Vol 110 (3) ◽  
pp. 457-459 ◽  
Author(s):  
Haruhisa Mita ◽  
Maki Hasegawa ◽  
Noritaka Higashi ◽  
Kazuo Akiyama
Keyword(s):  
Receptor Subtypes ◽  
Pge2 Receptor

scholarly journals Characterization of Endothelin-1 Receptor Subtypes in Isolated Human Cardiomyocytes

1999 ◽  
Vol 34 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Pietro Amedeo Modesti ◽  
Simone Vanni ◽  
Rita Paniccia ◽  
Brunella Bandinelli ◽  
Iacopo Bertolozzi ◽  
...  
Keyword(s):  
Receptor Subtypes ◽  
Human Cardiomyocytes ◽  
Endothelin 1
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