Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls

2007 ◽  
Vol 2007 ◽  
pp. 238-239
Author(s):  
S.E. Abram
Keyword(s):  
Isometric Exercise ◽  
Central Pain ◽  
Pain Mechanisms ◽  
Normal Controls

Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls

Pain ◽  
2005 ◽  
Vol 118 (1) ◽  
pp. 176-184 ◽  
Author(s):  
Roland Staud ◽  
Michael E. Robinson ◽  
Donald D. Price
Keyword(s):  
Isometric Exercise ◽  
Central Pain ◽  
Pain Mechanisms ◽  
Normal Controls

A Proposed Platform for Phenotyping Endometriosis-Associated Pain: Unifying Peripheral and Central Pain Mechanisms

2020 ◽  
Vol 9 (3) ◽  
pp. 89-97
Author(s):  
Paul J. Yong ◽  
Christina Williams ◽  
Mohamed A. Bedaiwy ◽  
Catherine Allaire
Keyword(s):  
Central Pain ◽  
Pain Mechanisms

Tension-Type Headache: Epidemiology, Diagnosis, and Pathophysiology

2016 ◽  
Author(s):  
Paul Rizzoli
Keyword(s):  
Large Body ◽  
Tension Type Headache ◽  
Central Pain ◽  
Pain Mechanisms ◽  
Epidemiologic Data ◽  
Prevalence Estimates ◽  
Socioeconomic Burden ◽  
Headache Epidemiology ◽  
Type Headache ◽  
Pathophysiologic Mechanisms

Tension-type headache (TTH) is a significant but underappreciated condition that is much more frequent than migraine, 42% versus 11%, and produces significant socioeconomic burden. Why then do research advances in this condition seem to lag? One reason is that precise epidemiologic data are lacking, with lifetime prevalence estimates varying from about 13 to 78%. Also, classification is confounded by whether or not to include the occasional but universal headache as TTH. Furthermore, TTH pathophysiology is debated, with some feeling that the pathophysiology of TTH is similar to and on a spectrum with migraine, and some feeling that it is entirely separate and related to peripheral and muscular mechanisms. More recently, central pain mechanisms have also been implicated in the pathophysiology. In addition, a large body of information connects stress and TTH. Although TTH varies widely in frequency and severity among and within patients, TTH pain, compared with pain in other headache types, could be characterized generally as more mild in severity and more generalized in location. This review discusses the current epidemiologic data and diagnostic challenges in TTH and the current pathophysiologic mechanisms.

Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment: Figure 1.

2011 ◽  
Vol 38 (8) ◽  
pp. 1546-1551 ◽  
Author(s):  
PHILIP J. MEASE ◽  
SYLVIA HANNA ◽  
ELIJAH P. FRAKES ◽  
ROY D. ALTMAN
Keyword(s):  
Literature Review ◽  
Tricyclic Antidepressants ◽  
Clinical Evidence ◽  
Genetic Variations ◽  
Peripheral Sensitization ◽  
Central Pain ◽  
Pain Mechanisms ◽  
Sensitivity To Pain

In this literature review, the mechanisms underlying pain associated with osteoarthritis (OA) are discussed, along with evidence for the efficacy of medications thought to act centrally to relieve OA pain. We survey the cascade of events from inflammation to activation of nociceptive and neuropathic pathways, to the development and maintenance of central and peripheral sensitization. Preclinical and clinical evidence for the sensitization hypothesis is discussed, along with recently identified genetic variations that may increase sensitivity to pain in patients with OA. Evidence is presented for the efficacy of centrally acting analgesics for OA pain (opioids, antiepileptics, tricyclic antidepressants, and serotonin/norepinephrine receptor inhibitors).

Central Pain Mechanisms

JAMA ◽  
1978 ◽  
Vol 239 (26) ◽  
Author(s):  
Rudolph H. de Jong
Keyword(s):  
Central Pain ◽  
Pain Mechanisms

scholarly journals Conditioned Pain Modulation Is Not Impaired in Individuals with Frozen Shoulder: A Case-Control Study

2021 ◽  
Vol 18 (23) ◽  
pp. 12330
Author(s):  
Marta Aguilar-Rodríguez ◽  
Lirios Dueñas ◽  
Mercè Balasch i Bernat ◽  
Mira Meeus ◽  
Filip Struyf ◽  
...  
Keyword(s):  
Frozen Shoulder ◽  
Pressure Pain Threshold ◽  
Conditioning Stimulus ◽  
Cross Sectional Study ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Central Pain ◽  
Cross Sectional ◽  
Pain Mechanisms ◽  
The Absolute

Frozen shoulder (FS) is a poorly understood condition resulting in substantial shoulder pain and mobility deficits. The mechanisms behind FS are not yet fully understood, but, similar to other persistent pain states, central pain mechanisms may contribute to ongoing symptoms in this population. The objective of this research was to investigate conditioned pain modulation (CPM) in people with FS compared with pain-free individuals. A total of 64 individuals with FS and 64 healthy volunteers participated in this cross-sectional study. CPM was assessed by using the pressure pain threshold (PPT) and an occlusion cuff (tourniquet test) as the test and conditioning stimulus, respectively. The absolute and percentage of change in PPT (CPM effect) as well as pain profiles (pro-nociceptive vs. anti-nociceptive) of individuals with FS and healthy controls were calculated. No significant differences in the absolute change in the PPT or CPM effect were found in people with FS compared to pain-free controls. Moreover, no between-group differences in the percentage of subjects with pro-nociceptive and anti-nociceptive pain profiles were observed. These results suggest that endogenous pain inhibition is normally functioning in people with FS. Altered central pain-processing mechanisms may thus not be a characteristic of this population.

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