Pharmacokinetics and safety of tanaproget, a nonsteroidal progesterone receptor agonist, in healthy women

2007 ◽  
Vol 2007 ◽  
pp. 228-229
Author(s):  
L.P. Shulman
Keyword(s):  
Progesterone Receptor ◽  
Receptor Agonist ◽  
Healthy Women

Pharmacokinetics and safety of tanaproget, a nonsteroidal progesterone receptor agonist, in healthy women

Contraception ◽  
2006 ◽  
Vol 74 (5) ◽  
pp. 414-418 ◽  
Author(s):  
Jody L. Bapst ◽  
James C. Ermer ◽  
Geraldine M. Ferron ◽  
Deborah Foss ◽  
Gayle P. Orczyk
Keyword(s):  
Progesterone Receptor ◽  
Receptor Agonist ◽  
Healthy Women

Carbon-11 Radiolabelling of Organosulfur Compounds:11C Synthesis of the Progesterone Receptor Agonist Tanaproget

2015 ◽  
Vol 21 (25) ◽  
pp. 9034-9038 ◽  
Author(s):  
Tom Haywood ◽  
Steven Kealey ◽  
Santiago Sánchez-Cabezas ◽  
James J. Hall ◽  
Louis Allott ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Agonist ◽  
Organosulfur Compounds

Moderate dieting causes 5-HT 2C receptor supersensitivity

1996 ◽  
Vol 26 (6) ◽  
pp. 1155-1159 ◽  
Author(s):  
P. J. Cowen ◽  
E. M. Clifford ◽  
A. E. S. Walsh ◽  
C. Williams ◽  
C. G. Fairburn
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Receptor Agonist ◽  
Plasma Concentrations ◽  
Developed Countries ◽  
Receptor Supersensitivity ◽  
Healthy Women ◽  
Prolactin Response

SynopsisDieting is a widespread behaviour in developed countries, which in predisposed individuals can lead to the development of clinical eating disorders such as bulimia nervosa and anorexia nervosa. We studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-HT) receptor agonist, m-chlorophenylpiperazine (mCPP), a measure of the sensitivity of post-synaptic 5-HT2C receptors. Dieting significantly increased the prolactin response to mCPP and lowered plasma concentrations of the 5-HT precursor, tryptophan. We propose that dieting in women is associated with the development of functional supersensitivity of 5-HT2C receptors, probably in response to lowered levels of brain 5-HT. Alterations in brain 5-HT neurotransmission could play a part in dieting-induced dysregulation of eating and the development of clinical eating disorders in predisposed individuals.

scholarly journals Effect of the Novel Selective Progesterone Receptor Modulator Vilaprisan on Ovarian Activity in Healthy Women

2017 ◽  
Vol 58 (2) ◽  
pp. 228-239 ◽  
Author(s):  
Barbara Schütt ◽  
Marcus-Hillert Schultze-Mosgau ◽  
Corinna Draeger ◽  
Xinying Chang ◽  
Stephanie Löwen ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Ovarian Activity ◽  
The Novel ◽  
Healthy Women ◽  
Receptor Modulator

scholarly journals Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone

2014 ◽  
Vol 111 (9) ◽  
pp. 3365-3370 ◽  
Author(s):  
Elizabeth L. Scholtz ◽  
Shweta Krishnan ◽  
Barry A. Ball ◽  
C. Jo Corbin ◽  
Benjamin C. Moeller ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Agonist

scholarly journals Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget

2005 ◽  
Vol 280 (31) ◽  
pp. 28468-28475 ◽  
Author(s):  
Zhiming Zhang ◽  
Andrea M. Olland ◽  
Yuan Zhu ◽  
Jeff Cohen ◽  
Tom Berrodin ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Agonist ◽  
Pharmacological Properties

Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis

2014 ◽  
Vol 276 (1-2) ◽  
pp. 89-97 ◽  
Author(s):  
Laura Garay ◽  
Maria Claudia Gonzalez Deniselle ◽  
Regine Sitruk-Ware ◽  
Rachida Guennoun ◽  
Michael Schumacher ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Receptor Agonist ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune
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