Y-Chromosome Variant May Explain Heart Disease Disparity

2010 ◽  
Vol 43 (15) ◽  
pp. 12
Author(s):  
BRUCE JANCIN
Keyword(s):  
Heart Disease ◽  
Y Chromosome ◽  
Chromosome Variant

Y-Chromosome Variant May Raise Risk of Heart Disease

2010 ◽  
Vol 40 (15) ◽  
pp. 40
Author(s):  
BRUCE JANCIN
Keyword(s):  
Heart Disease ◽  
Y Chromosome ◽  
Chromosome Variant

scholarly journals Y-Chromosome Variation in Southern African Khoe-San Populations Based on Whole-Genome Sequences

2020 ◽  
Vol 12 (7) ◽  
pp. 1031-1039 ◽  
Author(s):  
Thijessen Naidoo ◽  
Jingzi Xu ◽  
Mário Vicente ◽  
Helena Malmström ◽  
Himla Soodyall ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Sequence Data ◽  
Demographic History ◽  
Data Sets ◽  
High Coverage ◽  
Hunter Gatherers ◽  
Data Set ◽  
Chromosome Sequence ◽  
Shared Ancestry ◽  
Chromosome Variant

Abstract Although the human Y chromosome has effectively shown utility in uncovering facets of human evolution and population histories, the ascertainment bias present in early Y-chromosome variant data sets limited the accuracy of diversity and TMRCA estimates obtained from them. The advent of next-generation sequencing, however, has removed this bias and allowed for the discovery of thousands of new variants for use in improving the Y-chromosome phylogeny and computing estimates that are more accurate. Here, we describe the high-coverage sequencing of the whole Y chromosome in a data set of 19 male Khoe-San individuals in comparison with existing whole Y-chromosome sequence data. Due to the increased resolution, we potentially resolve the source of haplogroup B-P70 in the Khoe-San, and reconcile recently published haplogroup A-M51 data with the most recent version of the ISOGG Y-chromosome phylogeny. Our results also improve the positioning of tentatively placed new branches of the ISOGG Y-chromosome phylogeny. The distribution of major Y-chromosome haplogroups in the Khoe-San and other African groups coincide with the emerging picture of African demographic history; with E-M2 linked to the agriculturalist Bantu expansion, E-M35 linked to pastoralist eastern African migrations, B-M112 linked to earlier east-south gene flow, A-M14 linked to shared ancestry with central African rainforest hunter-gatherers, and A-M51 potentially unique to the Khoe-San.

scholarly journals A Novel Y-Chromosome Variant Puts an Upper Limit on the Timing of First Entry into the Americas

2003 ◽  
Vol 73 (3) ◽  
pp. 700-705 ◽  
Author(s):  
Mark Seielstad ◽  
Nadira Yuldasheva ◽  
Nadia Singh ◽  
Peter Underhill ◽  
Peter Oefner ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Upper Limit ◽  
Chromosome Variant

PHENYTOIN-ASSOCIATED CONGENITAL DEFECTS WITH Y-CHROMOSOME VARIANT

The Lancet ◽  
1973 ◽  
Vol 301 (7802) ◽  
pp. 559 ◽  
Author(s):  
PeterK. Lewin
Keyword(s):  
Y Chromosome ◽  
Congenital Defects ◽  
Chromosome Variant

Epidemiology of congenital heart disease. Observations in 17,366 Denver school children

JAMA ◽  
1966 ◽  
Vol 195 (13) ◽  
pp. 1107-1110 ◽  
Author(s):  
W. E. Morton
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
School Children ◽  
Congenital Heart

Arteriosclerotic heart disease in Roseto, Pennsylvania

JAMA ◽  
1966 ◽  
Vol 195 (2) ◽  
pp. 93-95 ◽  
Author(s):  
A. Keys
Keyword(s):  
Heart Disease ◽  
Arteriosclerotic Heart Disease

Isoproterenol in treatment of heart disease. Hemodynamic effects in circulatory failure

JAMA ◽  
1966 ◽  
Vol 197 (5) ◽  
pp. 315-320 ◽  
Author(s):  
W. C. Elliott
Keyword(s):  
Heart Disease ◽  
Circulatory Failure ◽  
Hemodynamic Effects

Discontinuation of antistreptococcal prophylaxis. A double-blind study in rheumatic patients free of heart disease

JAMA ◽  
1966 ◽  
Vol 197 (12) ◽  
pp. 949-952 ◽  
Author(s):  
A. R. Feinstein
Keyword(s):  
Heart Disease ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Rheumatic Patients

Further Comparative Studies on Ascites in Liver and Heart Disease

1950 ◽  
Vol 16 (1) ◽  
pp. 91-103 ◽  
Author(s):  
John A. Layne ◽  
F.R. Schemm ◽  
W.W. Hurst
Keyword(s):  
Heart Disease ◽  
Comparative Studies
Sign in / Sign up

Export Citation Format

Share Document