27A Targeting the PI3K/mTOR pathway in genetically engineered mouse models of advanced prostate cancer

2010 ◽  
Vol 8 (7) ◽  
pp. 18-19
Author(s):  
A. Patnaik ◽  
K. Courtney ◽  
S. Signoretti ◽  
M. Loda ◽  
A. Grant ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Advanced Prostate Cancer ◽  
Genetically Engineered ◽  
Mtor Pathway ◽  
Genetically Engineered Mouse Models

Abstract LB-418: Targeting the PI3K/mTOR pathway in genetically engineered mouse models of prostate cancer

2011 ◽  
Author(s):  
Akash Patnaik ◽  
Kevin Courtney ◽  
Gary Bellinger ◽  
Elaine Lunsford ◽  
Kyle Robichaud ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Genetically Engineered ◽  
Mtor Pathway ◽  
Genetically Engineered Mouse Models

scholarly journals Mouse Models of Prostate Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-22 ◽  
Author(s):  
Kenneth C. Valkenburg ◽  
Bart O. Williams
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Human Disease ◽  
High Throughput Screening ◽  
Genetically Engineered ◽  
Screening Methods ◽  
Human Prostate Cancer ◽  
Genetic Changes ◽  
Genetic Pathways ◽  
Genetically Engineered Mouse Models

The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. In this paper, we focus on the historical development and phenotypic descriptions of mouse models used to study prostate cancer. We also comment on how closely each model recapitulates human prostate cancer.

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