GENETICALLY ENGINEERED MOUSE MODELS IN PROSTATE CANCER RESEARCH

2011 ◽  
pp. 219-282 ◽  
Author(s):  
Fen Wang ◽  
Wallace L. McKeehan ◽  
Michael M. Shen ◽  
Cory Abate-Shen
2011 ◽  
Vol 2011 ◽  
pp. 1-22 ◽  
Author(s):  
Kenneth C. Valkenburg ◽  
Bart O. Williams

The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. In this paper, we focus on the historical development and phenotypic descriptions of mouse models used to study prostate cancer. We also comment on how closely each model recapitulates human prostate cancer.


2010 ◽  
Vol 10 (7) ◽  
pp. 470-480 ◽  
Author(s):  
Joerg Heyer ◽  
Lawrence N. Kwong ◽  
Scott W. Lowe ◽  
Lynda Chin

Sign in / Sign up

Export Citation Format

Share Document