Patient-reported outcomes with durvalumab after chemoradiotherapy in stage III, unresectable non-small-cell lung cancer (PACIFIC): a randomised, controlled, phase 3 study

2019 ◽  
Vol 20 (12) ◽  
pp. 1670-1680 ◽  
Author(s):  
Rina Hui ◽  
Mustafa Özgüroğlu ◽  
Augusto Villegas ◽  
Davey Daniel ◽  
David Vicente ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Patient Reported Outcomes ◽  
Small Cell ◽  
Stage Iii ◽  
Small Cell Lung ◽  
Phase 3 ◽  
Patient Reported ◽  
Randomised Controlled

scholarly journals Patient-reported outcomes with durvalumab by PD-L1 expression and prior chemoradiotherapy-related variables in unresectable stage III non-small-cell lung cancer

2021 ◽  
Vol 17 (10) ◽  
pp. 1165-1184
Author(s):  
Marina C Garassino ◽  
Luis Paz-Ares ◽  
Rina Hui ◽  
Corinne Faivre-Finn ◽  
Alex Spira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Patient Reported Outcomes ◽  
Small Cell ◽  
Phase Iii ◽  
Stage Iii ◽  
Small Cell Lung ◽  
Unresectable Stage ◽  
Patient Reported

Aim: We retrospectively investigated the impact of tumor PD-L1 expression and prior chemoradiotherapy (CRT)-related variables on patient-reported outcomes (PROs) from PACIFIC. Patients & methods: PACIFIC was a Phase III study of durvalumab versus placebo after CRT in patients with unresectable, stage III non-small-cell lung cancer. If available, pre-CRT tumor tissue was tested for PD-L1 tumor-cell expression, scored at prespecified (25%) and post-hoc (1%) cut-offs. PROs were assessed using EORTC QLQ C30/-LC13. Results: Similar to the intent-to-treat (ITT) population, most PROs remained stable over time across PD-L1 and CRT subgroups, with few clinically relevant differences between treatment arms. Time to deterioration was generally similar to the ITT population. Conclusion: Neither PD-L1 expression nor prior CRT-related variables influenced PROs with durvalumab therapy. Clinical trial registration: NCT02125461 (ClinicalTrials.gov)

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