scholarly journals Polypharmacy in chronic heart failure: practical issues regarding the use of angiotensin-converting enzyme inhibitors, beta-blockers and other drugs

2002 ◽  
Vol 4 ◽  
pp. D111-D116 ◽  
Author(s):  
R DEBOER ◽  
D VANVELDHUISEN
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Beta Blockers ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors

scholarly journals Epidemiology and treatment of chronic heart failure; use of bisoprolol

2013 ◽  
Vol 154 (44) ◽  
pp. 1731-1734
Author(s):  
Viktor Nagy
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Receptor Blockers

The prevalence of chronic heart failure in Hungary is 1.6% in the adult population, but it occurs in 15–20% of subjects over 80 years of age. The base of treatment of heart failure is the blockade of the neuro-hormonal system, which includes the use of angiotensin converting enzyme inhibitors (angiotensin receptor blockers in case of angiotensin converting enzyme inhibitors intolerance), beta receptor blockers and mineralocorticoid receptor antagonists. Because of their negative inotropic effect, beta blockers were neglected for a long time from the treatment of heart failure. However, during the past decades several studies have demonstrated that beta blockers decrease mortality in patients with heart failure. The effectiveness of bisoprolol in reducing mortality has also also been documented in a number of studies. Orv. Hetil., 154 (44), 1731–1734.

scholarly journals Dose Up-Titration Of Neurohormone Blockers For Chronic Heart Failure Treatment In Real Clinical Practice: Data From Single University Centre

2015 ◽  
Vol 25 (6) ◽  
pp. 70-72
Author(s):  
Aušra Kavoliūnienė ◽  
Goda Maciulevičiūtė ◽  
Rasa Sadeckaitė ◽  
Kristina Vasiljevaitė
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Beta Blockers ◽  
Research Programme ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
European Society Of Cardiology

Objective. To describe treatment peculiarities of ambulatory chronic heart failure patients’ in one of Lithuania’s university centres, participating in European Society of Cardiology EURObservation Research Programme (EORP) Heart Failure Long- Term Registry. Methods. 240 ambulatory patients with chronic heart failure were entered in European Society of Cardiology EURObservation Research Programme (EORP) Heart Failure Long-Term Registry from our university centre between May 2011 and March 2013. Follow-up data were collected after 12 months. Registered data about heart failure treatment were included to this study. Statistical analysis was performed with SPSS 22 program. Results. In our centre 67,1% of patients received angiotensin converting enzyme inhibitors at target doses, one third (34,3%) had not reached target doses due to symptomatic hypotension. Beta blockers were up-titrated to target doses for 82,5% of patients and the main reasons for failure to reach their target dose were: symptomatic bradycardia (12,7%), symptomatic hypotension (10,7%). Mineralocorticoid receptor antagonists were up-titrated to a target doses just for half of the patients – 52,1% and the most frequent reason for not reaching target doses was hyperkalemia (15,4%). Conclusions. Angiotensin converting enzyme inhibitors, beta-blockers and mineralocorticoid receptors antagonists, except angiotensin receptor blockers, were prescribed in a guideline-recommended doses. The main reasons why the target doses of neurohormone blockers have not been achieved were symptomatic hypotension for angiotensin converting enzyme inhibitors, symptomatic bradycardia for beta-blockers and hyperkalemia for mineralocorticoid receptors antagonists.

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