Feasibility, safety and dosimetry of intramural administration of 32P-oligonucleotide-mediating beta-particle delivery to prevent restenosis

ABSTRACTVertically integrated particle sensors have been developed using thin-film on ASIC technology. Hydrogenated amorphous silicon n-i-p diodes have been optimized for particle detection. These devices were first deposited on glass substrates to optimize the material properties and the dark current of very thick diodes (with thickness up to 50 m). Corresponding diodes were later directly deposited on two types of CMOS readout chips. These vertically integrated particle sensors were tested in beta particle beam from 63Ni and 90Sr sources. Detection of single low- and high- energy beta particle was achieved.

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A Beta-Particle Hodoscope Constructed Using A Position-Sensitive Plastic Scintillator Active Element

2006 IEEE Nuclear Science Symposium Conference Record ◽

10.1109/nssmic.2006.356062 ◽

2006 ◽

Author(s):

John L. Orrell ◽

Craig E. Aalseth ◽

Anthony R. Day ◽

James E. Fast ◽

Todd W. Hossbach ◽

...

Keyword(s):

Active Element ◽

Plastic Scintillator ◽

Beta Particle ◽

Position Sensitive

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Study of Afterglow and Thermoluminescence Properties of Synthetic Opal-C Nanoparticles for In Vivo Dosimetry Applications

MRS Proceedings ◽

10.1557/opl.2013.205 ◽

2013 ◽

Vol 1530 ◽

Author(s):

Marlen Hernández-Ortiz ◽

Laura S. Acosta-Torres ◽

Rodolfo Bernal ◽

Catalina Cruz-Vázquez ◽

Víctor M. Castaño

Keyword(s):

Radiation Dosimetry ◽

Dose Range ◽

Beta Particle ◽

In Vivo Dosimetry ◽

Synthetic Opal ◽

Genotoxic Effects ◽

Stöber Method ◽

Particle Irradiation ◽

The Stöber Method

ABSTRACTOpal particles, with diameter ca. 80 nm, were synthesized by the Stöber method. Samples were exposed to 100 Gy of beta particle irradiation and its thermoluminescence (TL) emission was recorded. TL response presents good reproducibility, standard deviation 1 %. The glow curve displays two TL peaks 86 and 400 °C and the afterglow (AG) phenomenon is observed immediately after irradiation (< 150°C). The synthetic opal-C exhibits a linear dependence of AG response as function of dose from 0.25 to 8 Gy. This dose range is of interest for personal and clinical dosimetry. Moreover, a previous study indicates that cytotoxic and genotoxic effects caused by opal nanoparticles, did not induce unrepairable DNA damage neither a cellular harm. Therefore, our results show synthetic opal-C is a material useful for in vivo radiation dosimetry.

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