Experimental determination of modulation power of lung tissue for particle therapy

In particle therapy of lung tumors, modulating effects on the particle beam may occur due to the microscopic structure of the lung tissue. These effects are caused by the heterogeneous nature of the lung tissue and cannot be completely taken into account during treatment planning, because these micro structures are too small to be fully resolved in the planning CT. In several publications, a new material parameter called modulation power (P mod ) was introduced to characterize the effect. For various artificial lung surrogates, this parameter was measured and published by other groups and ranges up to approximately 1000 µm. Studies investigating the influence of the modulation power on the dose distribution during irradiation are using this parameter in the rang of 100 to 800 µm. More precise measurements for P mod on real lung tissue have not yet been published. In this work, the modulation power of real lung tissue was measured using porcine lungs in order to produce more reliable data of P mod for real lung tissue. For this purpose, ex-vivo porcine lungs were frozen in a ventilated state and measurements in a carbon ion beam were performed. Due to the way the lungs were prepared and transferred to a solid state, the lung structures that modulate the beam could also be examined in detail using micro CT imaging. An optimization of the established methods of measuring the modulation power, which takes better account of the typical structures within lung tissue, was developed as well.

Numerical Study of Powder Flow Nozzle for Laser-Assisted Metal Deposition

Metal additive manufacturing has received much attention in the past few decades, and it offers a variety of technologies for three-dimensional object production. One of such technologies, allowing large-sized object production, is laser-assisted metal deposition, the limits of which are determined by the capabilities of the positioning system. The already-existing nozzles have either a relatively low build rate or a poor resolution. The goal of this work is to develop a new nozzle with a centered particle beam at high velocity for the laser-assisted metal additive manufacturing technologies. Scientific challenges are addressed with regards to the fluid dynamics, the particle-substrate contact, and tracking of the thermodynamic state during contact. In this paper, two nozzles based on the de Laval geometry with Witoszynski and Bicubic curves of convergence zone were designed; the results showed that the average flow velocity in a Bicubic outlet curve nozzle is around 615 m/s and in Witoszynski this is 435 m/s. Investigation of particle beam formation for the Bicubic curve geometry revealed that small particles have the highest velocity and the lowest total force at the nozzle outlet. Fine particles have a shorter response time, and therefore, a smaller dispersion area. The elasto-plastic particle-surface contact showed that particles of diameter limited up to 3 μm are able to reach experimentally obtained critical velocity without additional heating. For particle sizes above 10 μm, additional heating is needed for deposition. The maximum coefficient of restitution (COR) is achieved with a particle size of 30 μm; smaller particles are characterized by the values of COR, which are lower due to a relatively high velocity. Particles larger than 30 μm are scalable, characterized by a small change in velocity and a rise in temperature as their mass increases.

Optimizing the geometry of aerodynamic lens injectors for single-particle coherent diffractive imaging of gold nanoparticles

Single-particle X-ray diffractive imaging (SPI) of small (bio-)nanoparticles (NPs) requires optimized injectors to collect sufficient diffraction patterns to allow for the reconstruction of the NP structure with high resolution. Typically, aerodynamic lens-stack injectors are used for NP injection. However, current injectors were developed for larger NPs (>100 nm), and their ability to generate high-density NP beams suffers with decreasing NP size. Here, an aerodynamic lens-stack injector with variable geometry and a geometry-optimization procedure are presented. The optimization for 50 nm gold-NP (AuNP) injection using a numerical-simulation infrastructure capable of calculating the carrier-gas flow and the particle trajectories through the injector is also introduced. The simulations were experimentally validated using spherical AuNPs and sucrose NPs. In addition, the optimized injector was compared with the standard-installation `Uppsala injector' for AuNPs. Results for these heavy particles showed a shift in the particle-beam focus position rather than a change in beam size, which results in a lower gas background for the optimized injector. Optimized aerodynamic lens-stack injectors will allow one to increase NP beam density, reduce the gas background, discover the limits of current injectors and contribute to structure determination of small NPs using SPI.

Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study

Purpose To evaluate the outcomes of particle therapy in cancer patients with cardiac implantable electronic devices (CIEDs). Materials and methods From April 2001 to March 2013, 19,585 patients were treated with proton beam therapy (PBT) or carbon ion therapy (CIT) at 8 institutions. Of these, 69 patients (0.4%, PBT 46, CIT 22, and PBT + CIT 1) with CIEDs (64 pacemakers, 4 implantable cardioverter defibrillators, and 1 with a cardiac resynchronization therapy defibrillator) were retrospectively reviewed. All the patients with CIEDs in this study were treated with the passive scattering type of particle beam therapy. Results Six (13%) of the 47 PBT patients, and none of the 23 CIT patients experienced CIED malfunctions (p = 0.105). Electrical resets (7) and over-sensing (3) occurred transiently in 6 patients. The distance between the edge of the irradiation field and the CIED was not associated with the incidence of malfunctions in 20 patients with lung cancer. A larger field size had a higher event rate but the test to evaluate trends as not statistically significant (p = 0.196). Conclusion Differences in the frequency of occurrence of device malfunctions for patients treated with PBT and patients treated with CIT did not reach statistical significance. The present study can be regarded as a benchmark study about the incidence of malfunctioning of CIED in passive scattering particle beam therapy and can be used as a reference for active scanning particle beam therapy.

Simulation of charged particle beam dynamics extracted from a plasma source

This paper presents the results of computer simulation in COMSOL Multiphysics of the hydrogen isotopes beam dynamics extracted from a plasma source of small linear accelerator. The beam energy was 100 keV. The simulation was carried out taking into account the charge exchange of ions on neutral gas molecules in the accelerating system. At the same time, the calculations took into account the process of secondary ion-electron emission from the surfaces of the accelerating system that are bombarded with both fast and slow ions. Consideration of this process made it possible to determine that the value of the electronic load is at least 50% of the main beam current of 100 μA. The inclusion in the trajectory analysis the magnetic field simulation in the secondary electrons generation area made it possible to determine the magnetic field strength, which effectively blocks secondary electrons on the target (3000 Gauss). Then it has been experimentally demonstrated that the discharge current in a plasma source automatically increases by 20% when using the magnetic suppression system on the target node (magnetic field strength is 3000 Gauss).

Particle Beam Therapy Tolerance and Outcome on Patients with Autoimmune Diseases: A Single Institution Matched Case–Control Study

It is unclear whether autoimmune diseases (ADs) may predispose patients to higher radiation-induced toxicity, and no data are available regarding particle therapy. Our objective was to determine if cancer patients with ADs have a higher incidence of complications after protons (PT) or carbon ion (CIRT) therapy. METHODS. In our retrospective monocentric study, 38 patients with ADs over 1829 patients were treated with particle therapy between 2011 and 2020. Thirteen patients had collagen vascular disease (CVD), five an inflammatory bowel disease (IBD) and twenty patients an organ-specific AD. Each patient was matched with two control patients without ADs on the basis of type/site of cancer, type of particle treatment, age, sex, hypertension and/or diabetes and previous surgery. RESULTS. No G4–5 complications were reported. In the AD group, the frequency of acute grade 3 (G3) toxicity was higher than in the control group (15.8% vs. 2.6%, p = 0.016). Compared to their matched controls, CVD–IBD patients had a higher frequency of G3 acute complications (27.7 vs. 2.6%, p = 0.002). There was no difference between AD patients (7.9%) and controls (2.6%) experiencing late G3 toxicity (p = 0.33). The 2 years disease-free survival was lower in AD patients than in controls (74% vs. 91%, p = 0.01), although the differences in terms of survival were not significant. CONCLUSIONS. G3 acute toxicity was more frequently reported in AD patients after PT or CIRT. Since no severe G4–G5 events were reported and in consideration of the benefit of particle therapy for selected cancers, we conclude that particle therapy should be not discouraged for patients with ADs. Further prospective studies are warranted to gain insight into toxicity in cancer patients with ADs enrolled for particle therapy.

Controlling the process of muon formation for muon-catalyzed fusion: method of non-destructive average muon sign detection

The recent development of intense muon sources (Holmlid, Swedish Patent SE 539,684 C 2 (2017)) is crucial for the use of muon-catalyzed fusion reactors (L. Holmlid, Fusion Science and Technology 75, 208 (2019)) which are likely to be the first generation of practical fusion reactors. For this purpose, only negative muons are useful. For existing sources where negative muons can be ejected (if not formed) preferentially, it is necessary to know the amount of negative muons to determine and optimize the fusion reactor efficiency on-line. Here, a method is developed to measure the absolute muon flux and its average sign without collecting or deflecting the muons. The muons from the patented muon generator have an energy of 100 MeV and above and an intensity of 1013 muons per laser pulse. Here, the detection of the relativistic laser-induced muons from H(0) is reported with a standard particle beam method, using a wire coil on a ferrite toroid as detector for the relativistic particles. The coil detection method shows that these relativistic particles are charged, thus not photons, neutrinos or neutral kaons. This makes the coil method superior to scintillator methods and it is the only possible method due to the large muon intensity. If an equal number of positive and negative mouns passed the coil, no signal would be observed. The signal at the coil in the case shown here is due to relativistic positive muons as concluded from a signal charge sign verification in the coil.