scholarly journals 683. Target Site Selection of HIV-1 siRNA Therapeutics

2003 ◽  
Vol 7 (5) ◽  
pp. S265
Keyword(s):  
Site Selection ◽  
Target Site ◽  
Target Site Selection ◽  
Hiv 1 ◽  
Selection Of

scholarly journals Target Site Selection of Pseudomonas putida Transposon Tn4652

2007 ◽  
Vol 189 (10) ◽  
pp. 3918-3921 ◽  
Author(s):  
Paula Ann Kivistik ◽  
Maia Kivisaar ◽  
Rita Hõrak
Keyword(s):  
Pseudomonas Putida ◽  
Site Selection ◽  
Consensus Sequence ◽  
Target Site ◽  
Target Site Selection ◽  
Insertion Sites ◽  
Site Recognition ◽  
Selection Of

ABSTRACT We analyzed the target preferences of a Tn3 family transposon Tn4652. Alignment of 93 different insertion sites revealed a consensus sequence which resembles that of Tn3, indicating that despite a low similarity between Tn4652 and Tn3 transposases, their target site recognition is conserved.

Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides

2009 ◽  
Vol 488 (2) ◽  
pp. 153-162
Author(s):  
Jan Snášel ◽  
Ivan Rosenberg ◽  
Ondřej Pačes ◽  
Iva Pichová
Keyword(s):  
Site Selection ◽  
Target Site ◽  
Target Site Selection ◽  
Hiv 1

Common Physical Properties of DNA Affecting Target Site Selection of Sleeping Beauty and other Tc1/mariner Transposable Elements

2002 ◽  
Vol 323 (3) ◽  
pp. 441-452 ◽  
Author(s):  
Thomas J. Vigdal ◽  
Christopher D. Kaufman ◽  
Zsuzsanna Izsvák ◽  
Daniel F. Voytas ◽  
Zoltán Ivics
Keyword(s):  
Transposable Elements ◽  
Physical Properties ◽  
Site Selection ◽  
Sleeping Beauty ◽  
Target Site ◽  
Target Site Selection ◽  
Selection Of

scholarly journals The integration preference of Sleeping Beauty at non-TA site is related to the transposon end sequences

2019 ◽  
Author(s):  
Yiting Zhou ◽  
Guangwei Ma ◽  
Jiawen Yang ◽  
Yabin Guo
Keyword(s):  
Site Selection ◽  
Genomic Dna ◽  
Consensus Sequence ◽  
Mouse Cell ◽  
Sleeping Beauty ◽  
Consensus Sequences ◽  
Target Site Selection ◽  
Target Sites ◽  
End Sequences ◽  
Selection Of

Abstract Background: Sleeping Beauty (SB) transposon had been thought to strictly integrate into TA dinucleotides. Recently, we found that SB also integrates into non-TA sites at a lower frequency. Here we performed further study on the non-TA integration of SB. Results: 1) SB can integrate into non-TA sites in HEK293T cells as well as in mouse cell lines. 2) Both the hyperactive transposase SB100X and the traditional SB11 catalyze integrations at non-TA sites. 3) The consensus sequence of the non-TA target sites only occur at the opposite side of the sequenced junction between transposon end and the genomic sequences, indicating that the integrations at non-TA sites are mainly aberrant integrations. 4) The consensus sequence of the non-TA target sites is corresponding to the transposon end sequence. When the transposon end sequence is mutated, the consensus sequences changed too. Conclusion: The interaction between the SB transposon end and genomic DNA may be involved in the target site selection of the SB integrations at non-TA sites.

Target-Site Selection

2018 ◽  
pp. 1172-1174
Author(s):  
Adam R. Parks ◽  
Joseph E. Peters
Keyword(s):  
Site Selection ◽  
Target Site ◽  
Target Site Selection

Similar Target Site Selection Occurs in Integration of Plant and Mammalian Retroposons

1998 ◽  
Vol 47 (4) ◽  
pp. 463-470 ◽  
Author(s):  
Christophe Tatout ◽  
Laurence Lavie ◽  
Jean-Marc Deragon
Keyword(s):  
Site Selection ◽  
Target Site ◽  
Target Site Selection
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