364 TISSUE REACTIONS OF SUTURE MATERIALS (POLIGLACTIN 910, CROME CATGUT AND POLYDIOXANONE) ON RAT BLADDER WALL AND THEIR ROLE IN BLADDER STONE FORMATION

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I. Erguder ◽  
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Murat Kosan ◽  
Umut Gonulalan ◽  
Bulent Ozturk ◽  
Sezer Kulacoglu ◽  
Imge Erguder ◽  
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Hernia ◽  
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pp. 429-430 ◽  
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Serdar Arisan ◽  
Aysim Ozagari ◽  
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...  

The aim of this study was to assess urinary bladder histopathology induced by the sling materials tension-free vaginal tape (TVT), vypro mesh, and intravaginal slingplasty (IVS). Thirty rats were studied: sham-operated controls, TVT, vypro, and IVS groups. After laparotomy, a 0.5- x 1-cm piece of mesh was implanted on the anterior bladder wall. The bladder was examined histopathologically after 12 weeks. Inflammation, foreign-body reaction, subserosal fibrosis, necrosis, and collagen deposition were graded. The Kruskal-Wallis and posthoc Dunn tests were used. The sham-operated rats showed no tissue reactions. The TVT, vypro, and IVS groups showed increased inflammation (p= 0.006,p= 0.031,p= 0.001), subserosal fibrosis (p= 0.0001), foreign-body reaction (p = 0.0001), and collagen deposition (p= 0.0001) as compared to sham. Inflammation was more intense in the IVS group as compared to the TVT and vypro groups (p= 0.041,p= 0.028). The bladder presented more increased inflammatory response to IVS than the other meshs. This may play a role in the ultimate outcomes or complications from slings.


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Author(s):  
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...  

PLoS ONE ◽  
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Vol 4 (6) ◽  
pp. e5852 ◽  
Author(s):  
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Yoram Vodovotz

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Magna Cottini da Fonseca Passos ◽  
Carolina Croccia ◽  
Glauciane Lacerda Miranda ◽  
...  

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