N7 Trinucleotide repeat length polymorphisms of the androgen receptor gene – a step forward in understanding the pathogenesis of prostate cancer

2009 ◽  
Vol 8 (8) ◽  
pp. 569
Author(s):  
A. Lemiński ◽  
A. Bińczak-Kuleta ◽  
M. Kaczmarczyk ◽  
M. Ostanek ◽  
K. Skonieczna ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Trinucleotide Repeat ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Length Polymorphisms

scholarly journals Trinucleotide repeat length in the first exon of the androgen receptor gene may be associated with prostate carcinogenesis and facilitate prediction of prostate cancer aggressiveness

2016 ◽  
Vol 126 (3) ◽  
pp. 201-203
Author(s):  
Artur Lemiński ◽  
Agnieszka Bińczak-Kuleta ◽  
Mariusz Kaczmarczyk ◽  
Karolina Skonieczna-Żydecka ◽  
Andrzej Ciechanowicz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Trinucleotide Repeat ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Prostate Carcinogenesis ◽  
Cancer Aggressiveness

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

Is reduced CAG repeat length in androgen receptor gene associated with risk of prostate cancer in Indian population?

2005 ◽  
Vol 68 (1) ◽  
pp. 55-60 ◽  
Author(s):  
DK Mishra ◽  
K Thangaraj ◽  
A Mandhani ◽  
A Kumar ◽  
RD Mittal
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Indian Population ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat

scholarly journals GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostate cancer risk in south Indian men

2006 ◽  
Vol 51 (11) ◽  
pp. 998-1005 ◽  
Author(s):  
Krishnaswamy Vijayalakshmi ◽  
Kumarasamy Thangaraj ◽  
Singh Rajender ◽  
Venkatesan Vettriselvi ◽  
Perumal Venkatesan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
South Indian ◽  
Indian Men

Association between androgen receptor gene CAG trinucleotide repeat length and testicular histology in older men

2006 ◽  
Vol 86 (4) ◽  
pp. 873-877 ◽  
Author(s):  
M DAKOUANEGIUDICELLI ◽  
B LEGRAND ◽  
M BERGERE ◽  
Y GIUDICELLI ◽  
O CUSSENOT ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Trinucleotide Repeat ◽  
Receptor Gene ◽  
Older Men ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Testicular Histology

Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer

Urology ◽  
1999 ◽  
Vol 53 (2) ◽  
pp. 378-380 ◽  
Author(s):  
Oliver Sartor ◽  
Qiang Zheng ◽  
James A Eastham
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat

Racial Variation in CAG Repeat Lengths Within the Androgen Receptor Gene Among Prostate Cancer Patients of Lower Socioeconomic Status

2002 ◽  
Vol 20 (17) ◽  
pp. 3599-3604 ◽  
Author(s):  
Charles L. Bennett ◽  
Douglas K. Price ◽  
Simon Kim ◽  
Dachao Liu ◽  
Borko D. Jovanovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Androgen Receptor ◽  
Cancer Patients ◽  
Gleason Score ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Stage D

PURPOSE: To evaluate (1) whether there were racial differences in the androgen receptor gene CAG repeat length and in clinical or laboratory attributes of prostate cancer at the time of diagnosis; (2) whether there were differences in race, Gleason score, prostate-specific antigen (PSA) level, and stage at diagnosis by androgen receptor gene CAG repeat length; and (3) whether sociodemographic, clinical, and laboratory based factors might be associated with advanced-stage prostate cancer. To our knowledge, our study is the first to report on CAG repeat lengths in a cohort of prostate cancer patients, which includes large numbers of African-American men. METHODS: CAG repeat lengths on the androgen receptor gene were evaluated for 151 African-American and 168 white veterans with prostate cancer. The χ2 test, t test, and logistic regression analyses were used to evaluate the associations between CAG repeat lengths and race, stage, histologic grade, and PSA levels at diagnosis. RESULTS: The mean age of the cohort at the time of diagnosis was 68.7 years. At presentation, 42.0% had stage D prostate cancer, 26.5% had Gleason scores of 8 to 10, and 53.0% had PSA levels ≥ 10 ng/dL. Mean androgen receptor gene CAG repeat length for white veterans was 21.9 (SD, 3.5) versus 19.8 (SD, 3.2) for African-American veterans (P = .001). Men with shorter CAG repeats were more likely to have stage D prostate cancer (P = .09) but were not more likely to have a higher PSA concentration or Gleason score. CONCLUSION: In this cohort of men with prostate cancer, short CAG repeat length on the androgen receptor gene was associated with African-American race and possibly with higher stage but not with other clinical or pathologic findings.

scholarly journals South Indian men with reduced CAG repeat length in the androgen receptor gene have an increased risk of prostate cancer

2006 ◽  
Vol 51 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Vijayalakshmi Krishnaswamy ◽  
Thangaraj Kumarasamy ◽  
Vettriselvi Venkatesan ◽  
Sunil Shroff ◽  
Vikram R. Jayanth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
South Indian ◽  
Increased Risk ◽  
Indian Men

Are GSTM1, GSTT1 and CAG Repeat Length of Androgen Receptor Gene Polymorphisms Associated with Risk of Prostate Cancer in Iranian Patients?

2010 ◽  
Vol 17 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Zahra Ousati Ashtiani ◽  
Sayed-Mohammad Hasheminasab ◽  
Mohsen Ayati ◽  
Bareto Sabah Goulian ◽  
Mohammad Hossein Modarressi
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Receptor Gene Polymorphisms ◽  
Iranian Patients
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