S190 Does perineural invasion in prostate needle biopsy predict positive surgical margin in radical prostatectomy specimens in cases with lower PSA levels and Gleason scores?

2013 ◽  
Vol 12 (4) ◽  
pp. e1298, S190
Author(s):  
O.H. Yuksel ◽  
A. Urkmez ◽  
A. Sahin ◽  
F. Uruc ◽  
A. Verit
Keyword(s):  
Radical Prostatectomy ◽  
Needle Biopsy ◽  
Perineural Invasion ◽  
Surgical Margin ◽  
Positive Surgical Margin ◽  
Prostate Needle Biopsy

CAN PERINEURAL INVASION ON PROSTATE NEEDLE BIOPSY PREDICT PROSTATE SPECIFIC ANTIGEN RECURRENCE AFTER RADICAL PROSTATECTOMY?

1999 ◽  
Vol 162 (1) ◽  
pp. 103-106 ◽  
Author(s):  
ALEXANDRE de la TAILLE ◽  
MARK A. RUBIN ◽  
EMILIA BAGIELLA ◽  
CARL A. OLSSON ◽  
RALPH BUTTYAN ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Needle Biopsy ◽  
Perineural Invasion ◽  
Specific Antigen ◽  
Prostate Needle Biopsy

scholarly journals Significance of nuclear factor kappa beta activation on prostate needle biopsy samples in the evaluation of Gleason score 6 prostatic carcinoma indolence

2019 ◽  
Author(s):  
Marko Zupančič ◽  
Boris Pospihalj ◽  
Snežana Cerović ◽  
Barbara Gazić ◽  
Primož Drev ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Surgical Margins ◽  
Cutoff Point ◽  
Positive Surgical Margin ◽  
Pathological Stage ◽  
Positive Surgical Margins ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens

Abstract Background. Prostate cancer (PCa) is the most common cancer in men in developed European countries. Majority of men newly diagnosed with PCa are candidates for primary curative therapy, either with radical prostatectomy (RP) or radiation. However, many PCa are low risk, even indolent and these patients are candidates for active surveillance, so the prediction of such cancers is needed to avoid overtreatment. The main goal of our study was to find out whether the immunohistochemical expression of NF-κB p65 in biopsy samples with Gleason score 3+3=6 (GS 6) can be a negative predictive factor for PCa indolence. Methods. Study was based on a retrospective cohort of 178 PCa patients with initial total PSA ≤ 10 ng/ml, number of needle biopsy specimens ≥8, GS 6 on biopsy and T1/T2 estimated clinical stage who underwent laparoscopic radical prostatectomy and whose archived formalin-fixed and paraffin-embedded (FFPE) prostate needle biopsy specimens were used for additional immunohistochemistry staining for detection of NF-κβ p65. Both cytoplasmatic and nuclear NF-κB p65 expression in biopsy cores with PCa were correlated with postoperative pathological stage, positive surgical margins, GS and biochemical progression (BP) of disease. The final analysis involved 123 patients regarding the postoperative stage, surgical margins and GS and 118 regarding the BP. Results. Postoperative pathological stage 3 was noticed in 27 (22%) and positive surgical margins were detected in 13 patients (10,6%). After median follow-up of 66 months, BP (PSA ≥ 0,05 ng/ml) occurred in 20 (16,9%) patients, 11 (55%) with GS 6 after RP and 9 (45%) with GS 7. Cytoplasmatic nor nuclear NF-κB p65 expressions were not significantly associated with pathological stage, positive surgical margin and postoperative GS. Patients with positive cytoplasmic NF-kB reaction had significantly more BP compared to those with negative cytoplasmic NF-kB reaction with PSA 0,2 ng/ml as cutoff point (p=0,015) and a trend towards more BP with PSA ≥ 0,05 ng/ml as cutoff point (p=0,068). Conclusions. Cytoplasmic expression of NF-κB is associated with more BP and might be an independent prognostic factor for recurrence-free survival (RFS), but further studies including larger patient cohorts are needed to confirm these initial results.

scholarly journals Relationship Between Perineural Invasion in Prostate Needle Biopsy Specimens and Pathologic Staging After Radical Prostatectomy

2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Hassan Niroomand ◽  
Mohammadreza Nowroozi ◽  
Mohsen Ayati ◽  
Hassan Jamshidian ◽  
Amir Arbab ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Needle Biopsy ◽  
Perineural Invasion ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens ◽  
Pathologic Staging

scholarly journals Can perineural invasion detected in prostate needle biopsy specimens predict surgical margin positivity in D’Amico low risk patients?

2016 ◽  
Vol 88 (2) ◽  
pp. 89 ◽  
Author(s):  
Ozgur Haki Yuksel ◽  
Ahmet Urkmez ◽  
Ayhan Verit
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Perineural Invasion ◽  
Clinical Stage ◽  
Prognostic Significance ◽  
Surgical Margin ◽  
Radical Retropubic Prostatectomy ◽  
Low Risk ◽  
Prostate Needle Biopsy

Objectives: In this study, our aim was to estimate the value of perineural invasion (PNI) in prostate needle biopsy (PNB) specimens in the prediction of surgical margin positivity (SMP) and its prognostic significance (upgrade Gleason Score) in patients who had undergone radical retropubic prostatectomy (RRP) with low risk prostate cancer according to D’Amico risk assessment. Materials and Methods: We retrospectively analyzed the data of 65 patients who were diagnosed as clinical stage T1c prostate cancer (PC) and underwent RRP between January 2010 and June 2013. Pathological specimens of PNB and RRP were separately examined for the parameters of PNI, vascular invasion (VI), Gleason Score (GS) and SMP. Results: The patients’ mean age was 63.65 ± 4.93 (range 47- 75) years. PNI in PNB specimens were identified in 12 of 65 patients and 11 of 12 patients showed SMP on RRP specimens. While 53 of 65 patients had not PNI on PNB, only 11 of them demonstrated SMP on RRP specimens. SMP was 30.64-fold more frequently encountered in PNB specimens obtained from PNI-positive patients relative to PNI-negative patients. In our study, PNI detected in PNB specimens was statistically significantly associated with SMP on RRP specimens (P = 0.0001). Conclusion: It is well known that higher PSA values and GS were independent predictors of SMP in clinically localized prostate cancer (CLPC). We think that PNI in PNB specimens may be a useful prognostic factor for predicting SMP in cases with CLPC.

667: The Positive Surgical Margin (SM) is no Independent Predictor for Biochemical Failure after Radical Prostatectomy (RRP)

2005 ◽  
Vol 173 (4S) ◽  
pp. 182-182
Author(s):  
Rein J. Palisaar ◽  
Joachim Noldus ◽  
Alexander Haese ◽  
Markus Graefen ◽  
Hartwig Huland
Keyword(s):  
Radical Prostatectomy ◽  
Independent Predictor ◽  
Surgical Margin ◽  
Biochemical Failure ◽  
Positive Surgical Margin

scholarly journals Prediction of a positive surgical margin and biochemical recurrence after robot-assisted radical prostatectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ching-Wei Yang ◽  
Hsiao-Hsien Wang ◽  
Mohamed Fayez Hassouna ◽  
Manish Chand ◽  
William J. S. Huang ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Biochemical Recurrence ◽  
Multivariable Analysis ◽  
Specific Antigen ◽  
Surgical Margin ◽  
Asian Population ◽  
Nerve Sparing ◽  
Positive Surgical Margin ◽  
Robot Assisted ◽  
Surgeon Experience

AbstractThe positive surgical margin (PSM) and biochemical recurrence (BCR) are two main factors associated with poor oncotherapeutic outcomes after prostatectomy. This is an Asian population study based on a single-surgeon experience to deeply investigate the predictors for PSM and BCR. We retrospectively included 419 robot-assisted radical prostatectomy cases. The number of PSM cases was 126 (30.1%), stratified as 22 (12.2%) in stage T2 and 103 (43.6%) in stage T3. Preoperative prostate-specific antigen (PSA) > 10 ng/mL (p = 0.047; odds ratio [OR] 1.712), intraoperative blood loss > 200 mL (p = 0.006; OR 4.01), and postoperative pT3 stage (p < 0.001; OR 6.901) were three independent predictors for PSM while PSA > 10 ng/mL (p < 0.015; hazard ratio [HR] 1.8), pT3 stage (p = 0.012; HR 2.264), International Society of Urological Pathology (ISUP) grade > 3 (p = 0.02; HR 1.964), and PSM (p = 0.027; HR 1.725) were four significant predictors for BCR in multivariable analysis. PSMs occurred mostly in the posterolateral regions (73.8%) which were associated with nerve-sparing procedures (p = 0.012) while apical PSMs were correlated intraoperative bleeding (p < 0.001). A high ratio of pT3 stage after RARP in our Asian population-based might surpass the influence of PSM on BCR. PSM was less significant than PSA and ISUP grade for predicting PSA recurrence in pT3 disease. Among PSM cases, unifocal and multifocal positive margins had a similar ratio of the BCR rate (p = 0.172) but ISUP grade > 3 (p = 0.002; HR 2.689) was a significant BCR predictor. These results indicate that PSA and pathological status are key factors influencing PSM and BCR.

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