Prostate cancer active surveillance: Longitudinal health-related quality of life, IPSS and IIEF changes in the Finnish arm of the prospective PRIAS study with up to nine-years of follow-up

2018 ◽  
Vol 17 (2) ◽  
pp. e97-e98
Author(s):  
U. Lokman ◽  
H. Vasarainen ◽  
K. Lahdensuo ◽  
A. Erickson ◽  
T. Mirtti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Active Surveillance ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Health-Related Quality of Life following Cytoreductive Radical Prostatectomy in Patients with de-novo Oligometastatic Prostate Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5636
Author(s):  
Michael Chaloupka ◽  
Lina Stoermer ◽  
Maria Apfelbeck ◽  
Alexander Buchner ◽  
Vera Wenter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
De Novo ◽  
Health Related Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

(1) Background: local treatment of the primary tumor has become a valid therapeutic option in de-novo oligo-metastatic prostate cancer (PC). However, evidence regarding radical prostatectomy (RP) in this setting is still subpar, and the effect of cytoreductive RP on postoperative health-related quality of life (HRQOL) is still unclear. (2) Methods: for the current study, patients with de-novo oligo-metastatic PC (cM1-oligo), defined as ≤5 bone lesions in the preoperative staging, were included, and matched cohorts using the variables age, body-mass index (BMI), and pT-stage were generated. Patient-reported outcome measures (PROMS) were assessed pre- and postoperatively using the validated EORTC-QLQ-C30, IIEF-5, and ICIQ-SF questionnaires. The primary endpoint for univariate and multivariable analysis was good general HRQOL defined by previously validated cut-off values. (3) Results: in total, 1268 patients (n = 84 (7%) cM1-oligo) underwent RP between 2012 and 2020 at one tertiary care center. A matched cohort of 411 patients (n = 79 with oligo-metastatic bone disease (cM1-oligo) and n = 332 patients without clinical indication of metastatic disease (cM0)) was created. The median follow-up was 25mo. There was no significant difference in good general HRQOL rates between cM1-oligo-patients and cM0-patients before RP (45.6% vs. 55.2%, p = 0.186), and at time of follow-up (44% vs. 56%, p = 0.811). Global health status (GHS) worsened significantly in cM0-patients compared to baseline (−5, p = 0.001), whereas GHS did not change significantly in cM1-oligo-patients (+3.2, p = 0.381). In multivariate analysis stratified for good erectile function (IIEF5 > 18; OR 5.722, 95% CI 1.89–17.36, p = 0.002) and continence recovery (OR 1.671, 95% CI 1.03–2.70, p = 0.036), cM1-oligo was not an independent predictive feature for general HRQOL (OR 0.821, 95% CI 0.44–1.53, p = 0.536). (4) Conclusions: in this large contemporary retrospective analysis, we observed no significant difference in HRQOL in patients with the oligometastatic bone disease after cytoreductive radical prostatectomy, when compared to patients with localized disease at time of surgery.

Variation in Testosterone Levels and Health-related Quality of Life in Men Diagnosed With Prostate Cancer on Active Surveillance

Urology ◽  
2016 ◽  
Vol 94 ◽  
pp. 180-187 ◽  
Author(s):  
Andrew Cohen ◽  
Brittany Lapin ◽  
Chi H. Wang ◽  
Brian Helfand ◽  
David Victorson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Active Surveillance ◽  
Health Related Quality ◽  
Testosterone Levels ◽  
Related Quality ◽  
Health Related

scholarly journals Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study

2015 ◽  
Vol 9 (3) ◽  
pp. 500-511 ◽  
Author(s):  
Siobhan M. Phillips ◽  
Meir J. Stampfer ◽  
June M. Chan ◽  
Edward L. Giovannucci ◽  
Stacey A. Kenfield
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Health Professionals ◽  
Health Related Quality ◽  
Prostate Cancer Survivors ◽  
Follow Up Study ◽  
Related Quality ◽  
Health Related

274 Prostate cancer active surveillance: Health-related quality of life in the Finnish arm of the prospective PRIAS-study. Three year update

2013 ◽  
Vol 12 (1) ◽  
pp. e274-e275 ◽  
Author(s):  
U. Lokman ◽  
H. Vasarainen ◽  
K. Lahdensuo ◽  
A.M. Erickson ◽  
K. Taari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Active Surveillance ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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