Pharmacological therapy and vacuum device don't provide satisfactory results or can be contraindicated in a limited number of patients with erectile dysfunction (ED). The sole available option to treat their condition is represented by surgery. Penile prosthetic surgery is the most common surgical approach to restore erectile function but within the other options available, venous ligation and penile arterial revascularization should be considered in selected patients. Penile prosthesis implant is recommended in patients with organ failure who don't respond to medical therapy, in case of severe corporal fibrosis due to priapism, or when both ED and Peyronie’s disease are diagnosed. In relatively young patients not affected by severe vascular disease and diabetes with a documented stenosis of the internal pudendal artery, penile arterial revascularization can be considered. In case of congenital venous leakage, a further surgical treatment is represented by venous ligation that can provide satisfactory results in young patients.