Molecular detection of circulating neoplastic cells in patients with clinically localised gastric and non-gastric mucosa-associated lymphoid tissue lymphoma

2000 ◽  
Vol 32 (3) ◽  
pp. 188-191 ◽  
Author(s):  
F. Bertoni ◽  
M. Gisi ◽  
E. Roggero ◽  
A. Conconi ◽  
W. Mingrone ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Molecular Detection ◽  
Neoplastic Cells ◽  
Circulating Neoplastic Cells

scholarly journals Genetic Characterization and Clinical Features of Helicobacter pylori Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2993
Author(s):  
Barbara Kiesewetter ◽  
Christiane Copie-Bergman ◽  
Michael Levy ◽  
Fangtian Wu ◽  
Jehan Dupuis ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Signaling Pathways ◽  
Clinical Features ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Targeted Sequencing ◽  
Clinicopathological Parameters ◽  
Gastric Malt Lymphoma ◽  
Genetic Changes ◽  
H Pylori

Background: In Western countries, the prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma has declined over the last three decades. Contemporaneously, H. pylori negative gastric MALT lymphoma is increasingly encountered, and their genetic basis and clinical features remain elusive. Methods: A total of 57 cases of H. pylori negative gastric MALT lymphoma were reviewed and investigated for chromosome translocation by fluorescence in-situ hybridization and for somatic mutations by the targeted sequencing of 93 genes. Results: MALT1 translocation, most likely t(11;18)(q21;q21)/BIRC3-MALT1, was detected in 39% (22/57) cases, and IGH translocation was further seen in 12 MALT1-negative cases, together accounting for 60% of the cohort. Targeted sequencing was successful in 35 cases, and showed frequent mutations in NF-κB signaling pathways (TNFAIP3 = 23%, CARD11 = 9%, MAP3K14 = 9%), together affecting 14 cases (40%). The NF-κB pathway mutations were mutually exclusive from MALT1, albeit not IGH translocation, altogether occurring in 86% of cases. There was no significant correlation between the genetic changes and clinicopathological parameters. The patients showed a median of progression-free survival (PFS) of 66.3 months, and a significant superior PFS when treated with systemic versus antibiotic therapy (p = 0.004). Conclusion: H. pylori negative gastric MALT lymphoma is characterized by highly frequent genetic changes in the NF-κB signaling pathways.

Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma

2017 ◽  
Vol 58 (9) ◽  
pp. 2057-2064 ◽  
Author(s):  
Aurelien Amiot ◽  
Valerie Jooste ◽  
Charlotte Gagniere ◽  
Michaël Lévy ◽  
Christiane Copie-Bergman ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Second Primary ◽  
Second Primary Malignancies

Bone marrow involvement is rare in superficial gastric mucosa-associated lymphoid tissue lymphoma

2016 ◽  
Vol 48 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Jae Yong Park ◽  
Sang Gyun Kim ◽  
Joo Sung Kim ◽  
Hyun Chae Jung
Keyword(s):  
Bone Marrow ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Bone Marrow Involvement

scholarly journals Neonatal Thymectomy Favors Helicobacter pylori–Promoted Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Lesions in BALB/c Mice

2014 ◽  
Vol 184 (8) ◽  
pp. 2174-2184 ◽  
Author(s):  
Delphine Chrisment ◽  
Pierre Dubus ◽  
Lucie Chambonnier ◽  
Anaïs Hocès de la Guardia ◽  
Elodie Sifré ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Neonatal Thymectomy

Comparison of Localized Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma with and without Helicobacter pylori Infection

Helicobacter ◽  
2006 ◽  
Vol 11 (2) ◽  
pp. 86-95 ◽  
Author(s):  
Taiji Akamatsu ◽  
Taro Mochizuki ◽  
Yoko Okiyama ◽  
Akihiro Matsumoto ◽  
Hideharu Miyabayashi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Helicobacter Pylori Infection

scholarly journals 2 Cases of Gastric Mucosa-associated Lymphoid Tissue Lymphoma Presenting as a Submucosal Tumor-like Lesion

2010 ◽  
Vol 56 (2) ◽  
pp. 103 ◽  
Author(s):  
Bo Gwang Choi ◽  
Gwang Ha Kim ◽  
Jung Nam Lee ◽  
Sung Han Park ◽  
Bong Eun Lee ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Submucosal Tumor
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