T01.01.12 ANTI-PARIETAL CELL ANTIBODIES MAY BE NEGATIVE DESPITE HISTOLOGICAL CONFIRMATION OF AUTOIMMUNE ATROPHIC GASTRITIS: ROLE OF OLDER AGE

2020 ◽  
Vol 52 ◽  
pp. S56-S57
Author(s):  
L. Conti ◽  
M.V. Lenti ◽  
A. Di Sabatino ◽  
E. Miceli ◽  
G. Galli ◽  
...  
Blood ◽  
1966 ◽  
Vol 27 (5) ◽  
pp. 599-610 ◽  
Author(s):  
S. ARDEMAN ◽  
I. CHANARIN ◽  
A. JACOBS ◽  
LORRAINE GRIFFITHS

Abstract Addisonian pernicious anemia was present in 6 of 9 siblings (Generation II). All 9 siblings had evidence of gastric pathology as judged by the presence of antibodies against parietal cells, abnormalities in the gastric biopsy, and diminution of secretion of acid and intrinsic factor. Parietal cell antibodies were present in 10 of 17 offspring of these 9 siblings who were available for study. Gastric biopsy in the older members of this generation (III) showed atrophic gastritis; some of the younger members showed superficial gastritis. Loss of intrinsic factor was always accompanied by loss of gastric secreting cells and there was no evidence that decline of intrinsic factor secretion occurred independently of hydrochloric acid.


2012 ◽  
Vol 44 ◽  
pp. S61-S62
Author(s):  
E. Miceli ◽  
D. Padula ◽  
M.V. Lenti ◽  
V. Imbesi ◽  
M. Di Stefano ◽  
...  

Helicobacter ◽  
2020 ◽  
Vol 25 (5) ◽  
Author(s):  
Arzu Meltem Demir ◽  
Burcu Berberoğlu Ateş ◽  
Gülin Hızal ◽  
Aytaç Yaman ◽  
Ceyda Tuna Kırsaçlıoğlu ◽  
...  

1970 ◽  
Vol 56 (1) ◽  
pp. 71-77
Author(s):  
J. R. Kirkpatrick

AbstractGastric biopsy was performed on 107 dyspeptic patients over the age of 40 years. Varying degrees of atrophic gastritis were found in 65 per cent, the remainder having normal gastric mucosa. The incidence was lowest in those with duodenal ulcer, intestinal metaplasia not being found in any of this group.Hypochlorhydria was found in 77 per cent of those with atrophic gastritis and in 13 per cent of those with normal mucosa. The accuracy of barium meal, gastroscopy and gastric photography in discriminating between those with atrophic and those with normal gastric mucosa was less accurate.No significant haematological dilferences were found between the two groups of patients. Parietal cell antibodies were detected in the sera of 15 per cent of those cases with atrophic gastritis.


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