Screening of Eleven Commonly Used Traditional Chinese Medicines for Inhibitory Effects on Human Cytochrome P450 Enzymes

2017 ◽  
Vol 9 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Lin-hu Ye ◽  
Ling-ti Kong ◽  
Bing-xin Xiao ◽  
Qian Wang ◽  
Xiao-xi He ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Traditional Chinese Medicines ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Chinese Medicines ◽  
Human Cytochrome

Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes

2012 ◽  
Vol 13 (5) ◽  
pp. 599-614 ◽  
Author(s):  
Jing-Jing Wu ◽  
Chun-Zhi Ai ◽  
Yong Liu ◽  
Yan-Yan Zhang ◽  
Miao Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Traditional Chinese Medicines ◽  
Cytochrome P450 Enzymes ◽  
Chinese Medicines ◽  
Human Cytochrome

Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro

2013 ◽  
Vol 57 ◽  
pp. 262-265 ◽  
Author(s):  
Min He ◽  
Jian Jiang ◽  
Furong Qiu ◽  
Songcan Liu ◽  
Peng Peng ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Human Cytochrome

Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro

2011 ◽  
Vol 25 (8) ◽  
pp. 1828-1833 ◽  
Author(s):  
Yong-Long Han ◽  
Hong-Liang Yu ◽  
Dan Li ◽  
Xiang-Le Meng ◽  
Zhi-Yong Zhou ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
P Glycoprotein ◽  
Human Cytochrome

scholarly journals Inhibition of Human Cytochrome P450 Enzymes by Allergen RemovedRhus vernicifluaStoke Standardized Extract and Constituents

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hyunsik Jung ◽  
Sanghun Lee
Keyword(s):  
Cytochrome P450 ◽  
Drug Efficacy ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Serious Adverse Events ◽  
Rhus Verniciflua ◽  
Human Cytochrome ◽  
Cyp Isoforms ◽  
Inhibitory Potential ◽  
Potential Interactions

Objective. Potential interactions between herbal extracts and the cytochrome P450 (CYP) system lead to serious adverse events or decreased drug efficacy.Rhus vernicifluastoke (RVS) and its constituents have been reported to have various pharmacological properties. We evaluated the inhibitory potential of RVS and its constituents on the major CYP isoforms.Methods. The effects of allergen removed RVS (aRVS) standardized extract and major components, fustin and fisetin isolated from aRVS, were evaluated on CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 isoenzyme activity by a luminescent CYP recombinant human enzyme assay.Results. The aRVS extract showed relative potent inhibitory effects on the CYP2C9 (IC50, <0.001 μg/mL), CYP2C19 (IC50, 9.68 μg/mL), and CYP1A2 (IC50, 10.0 μg/mL). However, it showed weak inhibition on CYP3A4 and CYP2D6. Fustin showed moderate inhibitory effects on the CYP2C19 (IC50, 64.3 μg/mL) and weak inhibition of the other CYP isoforms similar to aRVS. Fisetin showed potent inhibitory effects on CYP2C9, CYP2C19, and CYP1A2. Fisetin showed moderate inhibition of CYP2D6 and weak inhibition of CYP3A4.Conclusions. These results indicate that aRVS, a clinically available herbal medicine, could contribute to herb-drug interactions when orally coadministered with drugs metabolized by CYP2C9, CYP2C19, and CYP1A2.

Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro

2018 ◽  
Vol 32 (8) ◽  
pp. e4250 ◽  
Author(s):  
Lin-Hu Ye ◽  
Xin-Qian Zhao ◽  
Ling-Ti Kong ◽  
Li-Sha Wang ◽  
Xue Tao ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Danhong Injection ◽  
Human Cytochrome
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