P356 Safety and PK results of a thorough QT/QTc (TQT) study of orally administered RPC1063, a novel, selective S1P1 receptor agonist

2014 ◽  
Vol 8 ◽  
pp. S213-S214 ◽  
Author(s):  
A. Olson ◽  
J. Hartung ◽  
G. Timony ◽  
R. Peach ◽  
M. Boehm ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
S1p1 Receptor

Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis

2014 ◽  
Vol 90 (1) ◽  
pp. 50-61 ◽  
Author(s):  
Jing Jin ◽  
Jinping Hu ◽  
Wanqi Zhou ◽  
Xiaojian Wang ◽  
Qiong Xiao ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Therapeutic Agent ◽  
Autoimmune Encephalitis ◽  
S1p1 Receptor ◽  
Potential Therapeutic Agent

scholarly journals Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

2011 ◽  
Vol 2 (6) ◽  
pp. 444-449 ◽  
Author(s):  
Emmanuel H. Demont ◽  
Benjamin I. Andrews ◽  
Rino A. Bit ◽  
Colin A. Campbell ◽  
Jason W. B. Cooke ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oral Dose ◽  
Receptor Agonist ◽  
S1p1 Receptor

Exploratory and Process Research on S1P1 Receptor Agonist CS-0777

2014 ◽  
Vol 72 (7) ◽  
pp. 808-821
Author(s):  
Takahide Nishi ◽  
Tsuyoshi Nakamura ◽  
Yoshitaka Nakamura
Keyword(s):  
Receptor Agonist ◽  
Process Research ◽  
S1p1 Receptor

scholarly journals Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis

2013 ◽  
Vol 4 (10) ◽  
pp. 942-947 ◽  
Author(s):  
Hongfeng Deng ◽  
Sylvie G. Bernier ◽  
Elisabeth Doyle ◽  
Jeanine Lorusso ◽  
Barry A. Morgan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Receptor Agonist ◽  
S1p1 Receptor ◽  
Clinical Candidate

An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

2016 ◽  
Vol 20 (5) ◽  
pp. 989-995 ◽  
Author(s):  
Xiaoping Hou ◽  
Juliang Zhu ◽  
Bang-Chi Chen ◽  
Scott H. Watterson ◽  
William J. Pitts ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Scale Up ◽  
S1p1 Receptor

Practical and Scalable Synthesis of S1P1 Receptor Agonist ACT-209905

2012 ◽  
Vol 16 (4) ◽  
pp. 595-604 ◽  
Author(s):  
Gunther Schmidt ◽  
Stefan Reber ◽  
Martin H. Bolli ◽  
Stefan Abele
Keyword(s):  
Receptor Agonist ◽  
S1p1 Receptor ◽  
Scalable Synthesis

358 A Small Molecule S1P1 Receptor Agonist With Significant Efficacy in Animal Models of Inflammatory Bowel Disease (IBD)

2012 ◽  
Vol 142 (5) ◽  
pp. S-84 ◽  
Author(s):  
Bryan Clemons ◽  
Harry Dedman ◽  
Rachel Powell ◽  
Esther Martinborough ◽  
Gregg Timony ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Animal Models ◽  
Small Molecule ◽  
Bowel Disease ◽  
Receptor Agonist ◽  
S1p1 Receptor ◽  
Significant Efficacy ◽  
Inflammatory Bowel

The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

2013 ◽  
Vol 17 (10) ◽  
pp. 1239-1246 ◽  
Author(s):  
Robert M. Harris ◽  
Benjamin I. Andrews ◽  
Stacy Clark ◽  
Jason W. B. Cooke ◽  
John C. S. Gray ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
S1p1 Receptor ◽  
Fit For Purpose ◽  
Robinson Annulation
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