Sildenafil Treatment of Unilateral Pulmonary Edema and Pulmonary Hypertension in Pulmonary Artery Agenesis

2006 ◽  
Vol 59 (12) ◽  
pp. 1347-1349
Author(s):  
Francisco Rodríguez-Gómez ◽  
Ignacio Martín ◽  
Ángel Sánchez ◽  
Emilio Pujol
1988 ◽  
Vol 62 (4) ◽  
pp. 327-330 ◽  
Author(s):  
Lucy Wood Arnold ◽  
John F. Keane ◽  
Jean S. Kan ◽  
Kenneth E. Fellows ◽  
James E. Lock

2020 ◽  
Vol 128 (5) ◽  
pp. 1432-1438
Author(s):  
Christina A. Eichstaedt ◽  
Nicola Benjamin ◽  
Ekkehard Grünig

Heritable pulmonary arterial hypertension (PAH) is an autosomal dominantly inherited disease caused by mutations in the bone morphogenetic protein receptor 2 ( BMPR2) gene and/or genes of its signaling pathway in ~85% of patients. A genetic predisposition to high-altitude pulmonary edema (HAPE) has long been suspected because of familial HAPE cases, but very few possibly disease-causing mutations have been identified to date. This minireview provides an overview of genetic analyses investigating common polymorphisms in HAPE-susceptible patients and the directed identification of disease-causing mutations in PAH patients. Increased pulmonary artery pressure is highlighted as an overlapping clinical feature of the two diseases. Moreover, studies showing increased pulmonary artery pressures in HAPE-susceptible patients during exercise or hypoxia as well as in healthy BMPR2 mutation carriers are illustrated. Finally, high-altitude pulmonary hypertension is introduced and future research perspectives outlined.


CHEST Journal ◽  
1995 ◽  
Vol 107 (6) ◽  
pp. 1766-1770 ◽  
Author(s):  
David B. Badesch ◽  
Martin R. Zamora ◽  
Steven Jones ◽  
David W. Campbell ◽  
David A. Fullerton

2011 ◽  
Vol 7 (3) ◽  
pp. E6-E9 ◽  
Author(s):  
Utku Arman Orun ◽  
Osman Yilmaz ◽  
Meki Bilici ◽  
Selmin Karademir ◽  
Cigdem Uner ◽  
...  

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