Prevalence of a History of Testicular Cancer in a Cohort of Elderly Twins

1995 ◽  
Vol 44 (3-4) ◽  
pp. 189-192 ◽  
Author(s):  
M. M. Braun ◽  
N. E. Caporaso ◽  
W. F. Page ◽  
R. N. Hoover

AbstractPrior studies have suggested that the risk of testicular cancer among dizygotic twins may exceed that among monozygotic twins or the general population. Cryptorchidism is associated with testicular cancer and twinship, and therefore might potentially explain the findings of the prior studies. In 1993-1994, when they were 66 to 77 years of age, 14,326 twin individuals in the National Academy of Sciencies-National Research Council Twin Registry were interviewed by telephone. A history of testicular cancer was reported by 5 (0.08%) of 5951 monozygotic twins and 11 (0.16%) of 6992 dizygotic twins. Follow-up interviews concerning testicular cancer risk factors and treatment were able to be administered to 4 of the monozygotic and 9 of the dizygotic twins reporting testicular cancer. A history of cryptorchidism was reported in the follow-up interview by only one dizygotic twin. Our data agree with the results of prior studies reporting a more frequent occurrence of testicular cancer among dizygotic than monozygotic twins. Although somewhat limited by small numbers, our study also suggests that the findings of increased testicular cancer in dizygotic twins are not explained simply by increased occurrence of cryptorchidism in twins.

1994 ◽  
Vol 43 (1-2) ◽  
pp. 89-94 ◽  
Author(s):  
M.M. Braun ◽  
R. Haupt ◽  
N.E. Caporaso

With recent advances in molecular biology and genetics, cohorts such as the National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry may become of increasing importance. This paper outlines the creation and history of the NAS-NRC Twin Registry, methodologies utilized for analysis of twin data, studies that have been completed or are underway, and possible future types of studies.


2015 ◽  
Vol 34 (2) ◽  
pp. 310-332 ◽  
Author(s):  
Renee M. Clary ◽  
James H. Wandersee

In many science classes, students encounter ‘final form’ science (Duschl 1990, 1994) in which scientific knowledge is presented as a rhetoric of conclusions (Schwab 1962). Incorporation of the history of science in modern science classrooms combats this false image of linear science progression. History of science can facilitate student understanding of the nature of science, pique student interest, and expose the cultural and societal constraints in which a science developed, revealing science's ‘human side’ (Matthews 1994). Carefully selected and researched episodes from the history of science illustrate that scientists sometimes chose incorrect hypotheses, misinterpreted data, and argued about data analysis. Our research documented that historical vignettes can hook students' attention, and past controversies can be used to develop students' analysis and argumentation skills before turning class attention to modern controversial issues. Historical graphics also have educational potential, as they reveal the progression of a science and offer alternative vehicles for data interpretation. In the United States, the National Science Education Standards (United States National Research Council 1996) acknowledged the importance of the History and Nature of Science by designating it as one of eight science content strands. However, the new United States Next Generation Science Standards (Achieve 2013) no longer include this strand, although the importance of the nature of science is still emphasized in the science framework (United States National Research Council 2012). Therefore, it is crucial that science education researchers continue to research and implement the history of science via interdisciplinary approaches to ensure its inclusion in United States science classrooms for better student understanding of the nature of science.


Author(s):  
Isabel Rábano

Resumen Se presentan algunos aspectos de la biografía de María Teresa Rodríguez Mellado (1921-1985), una pionera desconocida en la historia de la Geología española. El matrimonio y la maternidad la retiraron de la ciencia tras una breve pero intensa actividad investigadora. Licenciada en Ciencias, Sección de Ciencias Naturales, por la Universidad Central en 1946, obtuvo una beca del Consejo Superior de Investigaciones Científicas en el Museo de Ciencias Naturales de Madrid para realizar su tesis doctoral sobre el Devónico en España, dirigida por Francisco Hernández-Pacheco. Colaboró con Manuel Alía Medina en algunas cuestiones paleontológicas de las investigaciones geológico-mineras del Sáhara Occidental. Asimismo, se muestra la evolución de la enseñanza de las materias geológicas durante la primera mitad del siglo XX en España. Abstra ct This paper deals with some aspects of María Teresa Rodríguez Mellado´s biography (1921-1985), an unknown pioneer in the history of Spanish Geology. Marriage and motherhood removed her from science after a brief but intense research work. She graduated in Natural Sciences in 1946, and got a Spanish National Research Council scholarship to carry out her Ph.D. thesis on the Devonian of Spain, supervised by Francisco Hernández-Pacheco. She collaborated with Manuel Alía Medina on some paleontological issues of the geology of Western Sahara. Also, the evolution of the teaching of geological subjects during the first half of the 20th century in Spain is shown.


Author(s):  
Garrett Hardin

An often quoted passage of Arthur Conan Doyle's story "Silver Blaze" makes the point that the absence of data can be a datum. When the mystery of the purloined racehorse seems insoluble, Police Inspector Gregory asks Sherlock Holmes:… "Is there any point to which you would wish to draw my attention?" "To the curious incident of the dog in the night-time." "The dog did nothing in the night-time." "That was the curious incident," remarked Sherlock Holmes…. The dog that does not bark attracts no attention to itself. It takes insight to recognize that a nonhappening can be an alarm. Herman Daly showed a Holmeslike insight when he called attention to the bark that was absent from a would-be authoritative study made by a group of economists reporting to the prestigious National Research Council in 1986 on population growth and economic development. In 108 pages of text there is not a single mention of carrying capacity, a concept that should be central to all discussions of population and environment. It is as though gravity were left out of a treatise on the dynamics of the solar system; or assets and liabilities were left out of a textbook on business accounting. If civilization survives another century, and if there are still economists, a history of what will then be called "modern economics" may well begin with a belittling account of the "premodern" economics of the twentieth century in which carrying capacity plays no role. Nothing shows so well the impermeability of the barriers between academic disciplines as the silence of economists about a concept that dominates discussions of game management, a discipline concerned with population and environment problems as they affect animals other than Homo sapiens. Economists, dealing only with human populations, probably unconsciously embrace the human exemptionist doctrine (Chapter 15), though their commitment is seldom no more than implicit in their statements (Box 20-1). Two serious criticisms can be leveled against most of the authors quoted in the box. First, it is obvious that they desperately yearn for a world without limits. This is particularly evident in the last quotation, by Gro Harlem Brundtland, who chaired the United Nations commission that issued this statement. One can praise the heart of the commission without agreeing with the head.


PEDIATRICS ◽  
1964 ◽  
Vol 33 (4) ◽  
pp. 546-553
Author(s):  
Richard L. Naeye

The current study presents prenatal data on body, organ and placental development of monovular and diovulvar twins. Most twin measurements match mean values for single gestations through the 24th gestational week. Subsequently, growth of body and organs is not as rapid in twins as in single-born infants. Most measurements for dizygotic twins are greater than measurements for monozygotic twins at equivalent stages of gestation. Finally, a marked intrapair discordance in many body and organ measurements was found in a group of monochorionic twins with a maternal history of hydramnios. This discordance was related to the cross placental transfusion syndrome. The growth retardation evident in a group of 26 twins at birth largely disappeared by the end of the first postnatal year.


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