Foetal Warfarin Syndrome—a complex airway problem

1992 ◽  
Vol 106 (12) ◽  
pp. 1098-1099 ◽  
Author(s):  
J. D. T. Mason ◽  
A. Jardine ◽  
K. P. Gibbin
Keyword(s):  
Cardiac Surgery ◽  
First Trimester ◽  
Thromboembolic Disease ◽  
Feeding Problems ◽  
Feeding Difficulties ◽  
Child Bearing ◽  
Airway Problem ◽  
Trimester Exposure ◽  
Nasal Hypoplasia

AbstractPremature cartilaginous calcification and nasal hypoplasia following first trimester exposure to warfarin are known as the Foetal Warfarin Syndrome (FWS). There are over 40 cases reported in the literature, many of which describe breathing and feeding difficulties in the first few months of life. We report a case where a child had had difficulties breathing and feeding in the first months of life. These had been attributed to nasal hypoplasia. After proper ENT assessment the child benefitted from adenoidectomy.ENT surgeons should be aware of the syndrome as more women of child bearing age are taking warfarin following cardiac surgery and treatment of thromboembolic disease. ENT surgeons may be asked to review these children who often present with airway and feeding problems which have been attributed to nasal hypoplasia.

scholarly journals Kosovo’s Experience for Children with Feeding Difficulties after Cardiac Surgery for Congenital Heart Defect

2017 ◽  
Vol 5 (7) ◽  
pp. 920-924 ◽  
Author(s):  
Ramush Bejiqi ◽  
Ragip Retkoceri ◽  
Hana Bejiqi ◽  
Arlinda Maloku ◽  
Armend Vuciterna ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Heart Surgery ◽  
Chromosomal Abnormalities ◽  
Open Heart Surgery ◽  
Feeding Problems ◽  
Tertiary Referral Hospital ◽  
Feeding Disorder ◽  
Feeding Difficulties ◽  
Institutional Ethics ◽  
Prior Approval

BACKGROUND: A feeding disorder in infancy and during childhood is a complex condition involving different symptoms such as food refusal and faddiest, both leading to a decreased food intake.AIM: We aimed to assess the prevalence and predictor factors of feeding difficulties in children who underwent cardiac open heart surgery in neonatal period and infancy. We address selected nutritional and caloric requirements for children after cardiac surgery and explore nutritional interdependence with other system functions. METHODS: This was a retrospective study in a tertiary referral hospital, and prior approval from the institutional ethics committee was obtained. Information for 78 children (42 male and 36 female) was taken from patients charts. Data were analysed with descriptive statistics and logistic regression.RESULTS: From a cohort of analysed children with feeding problems we have occurred in 23% of such cases. At the time of the study, refusal to eat or poor appetite was reported as a significant problem in 19 children and subnormal height and weight were recorded in 11 children. Early neonatal intervention and reoperation were identified as risk factors for latter feeding difficulties or inadequate intake. Children with feeding problems also tended to eat less than children without feeding problems. There was a trend towards more feeding problems in patients with chromosomal abnormalities or other associated anomalies.CONCLUSION: Feeding disorder is often and a frequent long-term sequel in children after neonatal or early infancy heart surgery. Patients with chromosomal and associated anomalies who underwent multiple cardiac surgeries are at risk of developing feeding difficulties.

Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine

Teratology ◽  
2002 ◽  
Vol 65 (3) ◽  
pp. 125-130 ◽  
Author(s):  
Kenneth Lyons Jones ◽  
Kathleen A. Johnson ◽  
Lyn M. Dick ◽  
Robert J. Felix ◽  
Kelly K. Kao ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Trimester Exposure

scholarly journals Fetal Warfarin Syndrome – a case report

2022 ◽  
Vol 9 (1) ◽  
pp. 82-84
Author(s):  
Syed Sajid Hussain Shah ◽  
Bibi Aaliya
Keyword(s):  
Cardiac Surgery ◽  
Case Report ◽  
Family Planning ◽  
Plastic Surgery ◽  
Valve Replacement ◽  
Male Infant ◽  
Provisional Diagnosis ◽  
Initial Management ◽  
History Of ◽  
Nasal Hypoplasia

A two-month-old male infant presented with history of respiratory difficulty and got admitted with provisional diagnosis of pneumonia. On examination patient was having unilateral nasal hypoplasia and cyanosis with echocardiography showing truncus arteriosus. Detail history revealed that mother had valve replacement and she was taking warfarin during pregnancy. After initial management patient was referred to pediatric cardiac surgery and plastic surgery for further management. Parents were counseled regarding contraception and family planning.  

Continuation of pregnancy after first-trimester exposure to mifepristone: Is there a risk?

2011 ◽  
Vol 31 (2) ◽  
pp. 256-256 ◽  
Author(s):  
Nathalie Bernard ◽  
Marie-Pierre Cournot ◽  
Patrick Carlier ◽  
Martine Alt ◽  
Claude E. Barjhoux ◽  
...  
Keyword(s):  
First Trimester ◽  
Trimester Exposure

Aryepiglottoplasty for laryngomalacia: 100 consecutive cases

2001 ◽  
Vol 115 (1) ◽  
pp. 35-38 ◽  
Author(s):  
S. C. Toynton ◽  
M. W. Saunders ◽  
C. M. Bailey
Keyword(s):  
Complication Rate ◽  
Neurological Disease ◽  
Failure To Thrive ◽  
Indications For Surgery ◽  
Airway Compromise ◽  
Feeding Problems ◽  
Street Hospital ◽  
Feeding Difficulties ◽  
Great Ormond Street Hospital ◽  
Feeding Difficulty

A retrospective review of the notes of 100 consecutive patients who had undergone aryepiglottoplasty for laryngomalacia, at Great Ormond Street Hospital for Children, was undertaken. Fifty-six were male, 44 female and 47 were under three months of age. Indications for surgery were oxygen desaturation below 92 per cent and feeding difficulties causing failure to thrive. Forty-seven patients had other pathology contributing to their airway compromise or feeding problems. Improvement in stridor after one month was achieved in 86/91 (94.5 per cent) being abolished completely in 50/91 (55 per cent). Of the 25 per cent of patients whose symptoms took more than one week to resolve, 16/22 (63.6 per cent) were later found to have a serious neurological condition. Feeding was improved in 42 of 58 patients (72.4 per cent) who had a pre-operative feeding difficulty. The complication rate was low, with only five out of 86 (10 per cent) experiencing initial worsening of the airway and six per cent having aspiration of early feeds before improvement occurred.Endoscopic aryepiglottoplasty remains the operation of choice for patients with severe laryngomalacia, however, in the presence of neurological disease surgery is less likely to be successful.

scholarly journals First-Trimester Exposure to Gadolinium-based Contrast Agents: A Utilization Study of 4.6 Million U.S. Pregnancies

Radiology ◽  
2019 ◽  
Vol 293 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Steven T. Bird ◽  
Kate Gelperin ◽  
Leyla Sahin ◽  
Karen B. Bleich ◽  
Elnara Fazio-Eynullayeva ◽  
...  
Keyword(s):  
Contrast Agents ◽  
First Trimester ◽  
Trimester Exposure

#26 First trimester exposure to zopiclone

2019 ◽  
Vol 88 ◽  
pp. 141
Author(s):  
Wolfgang E. Paulus ◽  
Arkadius Polasik ◽  
Ulrike Friebe-Hoffmann
Keyword(s):  
First Trimester ◽  
Trimester Exposure
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