scholarly journals Nutrition of children and gastrointestinal microflora in the insult of diagnostic parameters

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Małgorzata Frajberg ◽  
Katarzyna Eufemia Przybyłowicz ◽  
Lucyna Kłe˛bukowska
Keyword(s):  
Abdominal Pain ◽  
Intestinal Microflora ◽  
Dietary Intervention ◽  
Intestinal Bacteria ◽  
Food Allergies ◽  
Functional Abdominal Pain ◽  
Double Blind ◽  
Blind Test ◽  
Before And After ◽  
Fodmap Diet

AbstractDoes dietary intervention affect the change of the intestinal microflora, causes the unsealing of the intestinal mucosa. After four weeks of dietary intervention with FODMAP diets and a diet based on NICE recommendations in children with functional abdominal pain, the intestinal microflora will change and the level of zonulin will decrease.Bacterial intestine, intestinal bacteria is a set of microorganisms, the main bacteria that form a complex ecosystem in the digestive tract. Scientific research indicates that some bacteria may contribute to the formation of certain disease entities.Children with functional abdominal pain participated in the research.The study was a randomized intervention and a double-blind test. 32 children were examined, patients of gastroenterological counseling center of the Provincial Specialist Children's Hospital in Olsztyn. Children were 4–12 years old, functional abdominal pain was diagnosed on the basis of Roman criteria, a positive decision of the gastroenterologist regarding the inclusion of the patient, conscious and voluntary consent of the child's guardian to participate in the study. Exclusion criteria include irritable bowel syndrome, abdominal migraine, diagnosed food allergies or food intolerance, the coexistence of chronic diseases or antibiotic therapy in the last 8 weeks.The dietary intervention lasted 4 weeks, meals were prepared on the basis of a menu developed by a dietician.Diagnostic tests were carried out before and after dietary intervention. One group of children with functional abdominal pain received the Fodmap diet, the second group, a diet based on NICE recommendations.The intestinal microflora, the level of zonulin in the stool were tested and the organic acids in the urine were determined by capillary gas chromatography/mass spectrometers (GC/MS).A preliminary analysis of test conditions prior to dietary intervention was found.Dysbiosis occurred in all 26 children (4 children did not perform the test). An increased number of Bacteroides spp. Was observed in the majority of children in stool tests, studies have reported that the growth of this bacterium in the intestinal microflora occurs in IBD intestinal inflammatory syndrome. Preliminary researches show that this bacterium was dominant in the examined children. In the test, an intermediate urine dysbiosis test of 24 out of 26 children was tested had at least one parameter elevated. After the dietary intervention, the diet had an effect on changing the intestinal microflora, changing the parameters of dysbiosis and the parameter of zonulin, although more research is needed on a larger population.

Low FODMAP Diet Is Not Effective in Children with Functional Abdominal Pain: A Randomized Controlled Trial

2020 ◽  
Vol 76 (5) ◽  
pp. 334-344
Author(s):  
Katarzyna Mirosława Boradyn ◽  
Katarzyna Eufemia Przybyłowicz ◽  
Elżbieta Jarocka-Cyrta
Keyword(s):  
Abdominal Pain ◽  
Dietary Intervention ◽  
Rating Scale ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Gastrointestinal Symptoms ◽  
Stool Consistency ◽  
Functional Abdominal Pain ◽  
Abdominal Symptoms ◽  
Fodmap Diet

<b><i>Introduction:</i></b> A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) has been shown to reduce symptoms among adult patients and children with irritable bowel syndrome. There are no studies investigating the effectiveness of the low FODMAP diet in pediatric patients with functional abdominal pain (FAP). <b><i>Objective:</i></b> The study aimed to evaluate the effectiveness of the low FODMAP diet in reducing gastrointestinal symptoms in children with FAP in comparison to the control diet based on the National Institute for Health and Care Excellence (NICE) guidelines<b>.</b> <b><i>Methods:</i></b> Twenty-seven children with diagnosed FAP were randomized to 2 groups. Each group received an intervention: the low FODMAP diet or the diet based on NICE. All food was prepared and delivered by a catering company. Data regarding gastrointestinal symptoms were recorded by participants during the 2-week baseline assessment and 4-week dietary intervention. The frequencies of abdominal pain and stools were reported as a number of events per day. The severity of abdominal pain was assessed using the Wong-Baker FACES Pain Rating Scale. The assessment of stool consistency was based on the Bristol Stool Form Scale. <b><i>Results:</i></b> The tendency toward the improvement in abdominal symptoms was noted in the low FODMAP group but without statistical significance. No significant differences in stool consistency were observed in this group. The NICE group experienced significant reduction in abdominal pain intensity and frequency (<i>p</i> &#x3c; 0.01) and improvement in stool consistency (93% reporting normal stool, <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> The results of this pilot study suggest that the low FODMAP diet is not effective in the reduction of symptoms in children with FAP.

scholarly journals Parental Opinion about the Low FODMAP Diet in Dietary Treatment of Children with Functional Abdominal Pain

2020 ◽  
Vol 17 (15) ◽  
pp. 5554
Author(s):  
Katarzyna Mirosława Boradyn ◽  
Elżbieta Jarocka-Cyrta ◽  
Katarzyna Eufemia Przybyłowicz ◽  
Małgorzata Obara-Gołębiowska
Keyword(s):  
Abdominal Pain ◽  
Dietary Intervention ◽  
Gastrointestinal Symptoms ◽  
Dietary Treatment ◽  
Lower Percentage ◽  
Functional Abdominal Pain ◽  
Self Assessment ◽  
Nice Guidelines ◽  
Parental Opinion ◽  
Fodmap Diet

The aim of this study was primarily to evaluate differences between parental opinion about the diet and overall changes in children’s symptoms of functional abdominal pain (FAP) during the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet and National Institute for Health and Care Excellence (NICE) diet. Secondly, this paper examined the agreement between parental perception of children’s symptoms and children’s self-assessment of symptoms during the diet in both treatment groups. Twenty-seven children with diagnosed functional abdominal pain (FAP) were randomized to one of two group, receiving the low FODMAP diet or the diet based on NICE guidelines. Children reported gastrointestinal symptoms at baseline and during the diet. At the end of the intervention, parents assessed their children’s diet and symptoms changes, using Likert scales. The agreement between parental and children assessments of gastrointestinal symptoms was defined as the percentage of compatible answers. In the low FODMAP group a significantly lower percentage of parents (38%) declared that it was easy to follow the diet, compared to the NICE group (57%), (p = 0.017). A high percentage of parents in both groups reported improvement in all symptoms of children during dietary intervention. A high level of agreement was also observed between parental and children’s self-assessment of abdominal pain intensity and frequency. Our research suggests that in parental opinion the low FODMAP diet is as effective as the diet based on NICE guidelines in children with FAP. However, the low FODMAP diet may seem more difficult to follow, and this may have had an impact on the effectiveness and acceptability of the FODMAP diet by children.

scholarly journals Does Social Exclusion Alter Sensory and Pain Thresholds in Children and Adolescents with Functional Abdominal Pain? – Results from a Preliminary Study

Pain Medicine ◽  
2018 ◽  
Vol 20 (8) ◽  
pp. 1472-1478
Author(s):  
Marco Daniel Gulewitsch ◽  
Aiste Jusyte ◽  
Katja Weimer ◽  
Michael Schönenberg
Keyword(s):  
Abdominal Pain ◽  
Social Exclusion ◽  
Experimental Studies ◽  
Control Group ◽  
Childhood And Adolescence ◽  
Sensory Threshold ◽  
Functional Abdominal Pain ◽  
Pain Thresholds ◽  
Before And After ◽  
Underlying Mechanisms

Abstract Objective Functional abdominal pain (AP) is a prevalent issue in childhood and adolescence. The contribution of psychosocial factors in the development and maintenance of this health problem is rather unclear, and experimental studies about underlying mechanisms are lacking. This study investigates whether experimentally induced social exclusion decreases sensory and pain thresholds in children suffering from AP. Subjects Twenty children/adolescents with AP and 22 healthy controls. Methods Children/adolescents participated in the Cyberball paradigm, which affects an experience of social exclusion. Thermal sensory and pain thresholds were measured before and after Cyberball. Results Children/adolescents with AP showed a divergent reaction regarding their sensory threshold after social exclusion: The control group exhibited a tendency toward a decreased sensory threshold whereas the AP group remained stable. Concerning the pain threshold, no effect of social exclusion could be identified. The increase of both thresholds (“numbing”) after Cyberball was positively correlated with symptoms of mental health issues. Conclusions This is the first study to investigate changes in sensory and pain thresholds following painful social interactions in a sample of children/adolescents with a chronic pain condition. Results suggest that AP and control children differ in their reaction of sensory thresholds, which might indicate an altered processing of social exclusion. Replication and further methodological improvements are needed.

scholarly journals Effect of a Low-fodmap Diet for the Management of Functional Abdominal Pain Disorders in Children: A Study Protocol for a Randomized Controlled Trial

2020 ◽  
Author(s):  
Agata Stróżyk ◽  
Andrea Horvath ◽  
Jane Muir ◽  
Hania Szajewska
Keyword(s):  
Randomized Controlled Trial ◽  
Abdominal Pain ◽  
Controlled Trial ◽  
Well Being ◽  
World Health ◽  
Reliable Change Index ◽  
Functional Abdominal Pain ◽  
Regular Diet ◽  
Randomized Controlled ◽  
Fodmap Diet

Abstract Background Evidence from studies in adults documents that fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) may be triggers of symptoms in individuals with functional abdominal pain disorders (FAPDs). However, in children, the evidence is very limited. We aim to assess the effects of a low-FODMAP diet compared with a regular diet for the management of children with FAPDs. Methods We will perform a randomized, quadruple-blinded, controlled trial. Seventy-four children aged 8 to 18 years with a FAPD (Irritable Bowel Syndrome or Functional Abdominal Pain-Not Otherwise Specified), diagnosed according to the Rome IV criteria, will be randomly allocated to receive either a low-FODMAP diet or a regular diet for 4 weeks. The primary outcome will be the percentage of the responders, defined as the participants who have at least 30% improvement in abdominal pain intensity on a Visual Analogue Scale (VAS) during the last week of the trial compared with baseline, that is at least equal to the Reliable Change Index (≥ 25 mm change on VAS). Other outcomes will include changes in stool consistency, abdominal pain frequency, total scores on the Gastrointestinal Symptom Rating Scale, KIDSCREEN-10 Index and World Health Organization Five Well-Being Index, child’s school attendance and parents’ work absenteeism, and BMI-for-age z-score. Compliance, tolerability of the low-FODMAP diet, and adverse events also will be evaluated. Each FAPD subtype will be assessed separately.DiscussionThere is a need for high-quality evidence regarding the dietary management of children with FAPDs. This randomized controlled trial (RCT) of rigorous methodological design will help to establish the effectiveness, if any, of a low-FODMAP diet for the management of FAPDs in the pediatric population. The findings of this RCT will assist with the development of guidelines and influence the direction of further research. Trial registration: NCT04528914

A multicenter, randomized, double-blind, placebo controlled, crossover trial on the efficacy of a mixture of three bifidobacteria in children with functional abdominal pain

2014 ◽  
Vol 46 ◽  
pp. e80 ◽  
Author(s):  
Eleonora Giannetti ◽  
Annalisa Alessandrella ◽  
Donatella De Giovanni ◽  
Angelo Campanozzi ◽  
Annamaria Staiano ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Crossover Trial ◽  
Functional Abdominal Pain ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Attentional bias to pain and social threat in pediatric patients with functional abdominal pain and pain-free youth before and after performance evaluation

Pain ◽  
2011 ◽  
Vol 152 (5) ◽  
pp. 1061-1067 ◽  
Author(s):  
Joy E. Beck ◽  
Tricia A. Lipani ◽  
Kari F. Baber ◽  
Lynette Dufton ◽  
Judy Garber ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Performance Evaluation ◽  
Attentional Bias ◽  
Pediatric Patients ◽  
Social Threat ◽  
Functional Abdominal Pain ◽  
Before And After

scholarly journals Lansoprazole for recurrent abdominal pain in adolescents

2011 ◽  
Vol 51 (4) ◽  
pp. 234
Author(s):  
Ade Saifan Surya ◽  
Selvi Nafianti ◽  
Melda Deliana ◽  
Supriatmo Supriatmo ◽  
Atan Baas Sinuhaji
Keyword(s):  
Abdominal Pain ◽  
Rating Scale ◽  
Controlled Trial ◽  
Drug Efficacy ◽  
Recurrent Abdominal Pain ◽  
Double Blind ◽  
Before And After ◽  
Pain Frequency ◽  
Physical Examinations

Background Recurrent abdominal pain is common among adolescents. School absenteeism and lower quality of life are associated with severity of symptoms. Lansoprazole has been used to treat recurrent abdominal pain.Objective To investigate the effectiveness of lansoprazole as a treatment for recurrent abdominal pain in adolescents.Methods We conducted a randomized, double-blind, controlled trial from August 2009 to October 2009. Adolescents suffering recurrent abdominal pain were eligible for the study. Simple randomization was done to divide subjects into two groups. Groups received 30 mg of lansoprazole or placebo, once a day for 14 days. Before treatment, we performed laboratory and physical examinations. Pain frequency was measured in number of abdominal pain episodes per month. Duration was measured in minutes and pain intensity was measured by a pain rating scale. Drug efficacy was measured before, during and after intervention. Data was analyzed using Mann-Whitney U-test and t-test.Results One hundred sixteen recurrent abdominal pain patients were randomized into two groups of 58 patients. There were no statistically significant differences in pain frequency before and after treatment for either the lansoprazole group or the placebo group (P=0.083, 95%CI, -0.033 to 0.021 and P=0.096, 95%CI -0.376 to 0.031, respectively). In addition, there were no significant differences in frequency, duration, and degree of abdominal pain at baseline and after 1, 2 and 3 months of treatment between the two groups.Conclusion Lansoprazole was not more effective than the placebo for treatment of recurrent abdominal pain among adolescents.

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