Regional cerebral blood flow (rCBF) in schizophrenia during verbal memory activation: a 99mTc-HMPAO single photon emission tomography (SPET) study

1994 ◽  
Vol 24 (2) ◽  
pp. 463-472 ◽  
Author(s):  
G. F. Busatto ◽  
D. C. Costa ◽  
P. J. Ell ◽  
L. S. Pilowsky ◽  
A. S. David ◽  
...  
Keyword(s):  
Verbal Memory ◽  
Medial Temporal Lobe ◽  
Single Photon ◽  
Photon Emission ◽  
Memory Task ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Schizophrenic Patients ◽  
Photon Emission Tomography

SynopsisRegional cerebral blood flow (rCBF) was investigated in a group of medicated DSM-III-R schizophrenic patients and age, sex and handedness matched normal volunteers using a split-dose 99mTc-HMPAO Single Photon Emission Tomography (SPET) protocol. Measures were taken during the performance of a verbal memory task aimed at activating the left medial temporal lobe, a region repeatedly suggested to be structurally abnormal in schizophrenia. In normal subjects, the performance of the task was associated with significant rCBF increases in the left medial temporal, left inferior frontal and anterior cingulate cortices, and right cerebellum. Despite their significantly poorer performance on the memory task, the degree of medial temporal activation measured in the schizophrenic patients was not significantly different from that found in the control group. This finding suggests that memory deficits in schizophrenia do not necessarily imply failure to activate the left medial temporal lobe as assessed by 99mTc-HMPAO SPET.

Effect of Central Cholinergic Stimulation on Regional Cerebral Blood Flow in Alzheimer's Disease

1991 ◽  
Vol 158 (4) ◽  
pp. 558-562 ◽  
Author(s):  
Ken Wilson ◽  
David Bowen ◽  
Paul Francis ◽  
Philippa Tyrrell
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Cholinergic Stimulation ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Photon Emission Tomography

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis

1989 ◽  
Vol 19 (4) ◽  
pp. 847-855 ◽  
Author(s):  
R. Hunter ◽  
R. McLuskie ◽  
D. Wyper ◽  
J. Patterson ◽  
J. E. Christie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Cortical Areas ◽  
Photon Emission Tomography

SYNOPSISSingle photon emission tomography (SPET) with the lipophilic blood flow marker99mTc-hexamethyl propyleneamine oxime (99mTc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions of patients with presenile Alzheimer's disease and Korsakoff's psychosis, and age-matched controls. Using occipital cortical uptake as reference area, the pattern of relative regional cerebral blood flow (rCBF) was determined in other cortical areas and basal ganglia. In Alzheimer's disease, reduction in rCBF occurred most strikingly in posterior temporal and parietal areas. By contrast, in Korsakoff's psychosis, posterior temporal rCBF was maintained, although there was a trend to reduced tracer uptake in other cortical areas. These impairments of flow were correlated with impairments of neuropsychological function. In Alzheimer's disease, left posterior temporal and left parietal regions in particular showed rCBF to be strongly correlated with most aspects of cognitive function. In Korsakoff's psychosis, however, impaired flow in frontal regions was correlated with impaired performance on tests of memory and orientation. The findings in Alzheimer's disease show quantitative parallels with those from studies using Positron Emission Tomography (PET), and extend our understanding of the relationship between cognition and regional brain function in dementia. The findings in Korsakoff's psychosis offer the first direct evidence linking frontal lobe dysfunction with the cognitive impairment seen in the disorder.

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