23.—The Synthesis of Derivatives of Acenaphthenone

1974 ◽  
Vol 71 (4) ◽  
pp. 279-283 ◽  
Author(s):  
Michael J. Bedford ◽  
Douglas A. Crombie
Keyword(s):  
Polymeric Material ◽  
Malonic Acid ◽  
Hydroxy Acid ◽  
Ethyl Cyanoacetate ◽  
Geometric Isomer ◽  
Unsaturated Ester ◽  
Image Position ◽  
Derivatives Of

Acenaphthenequinone (I) condensed with ethyl cyanoacetate in ethanol to give the unsaturated ester (IIIb) while condensation with malonic acid in toluene in the presence of diethylamine gave the hydroxy acid (IIa). Esterification of this acid gave an ester (IIb) which could also be obtained by condensation of acenaphthenequinonewith ethyl hydrogen malonate. The acid (IIa) on dehydration gave 2-oxo-Δ1,α-acenaphtheneacetic acid (IIIa) of m.p. 230°C. This result seems to be in conflict with that of Rodionov and Federova (1950) who reported a m.p. of 160° for the acid (IIIa) which they obtained directly by condensation of acenaphthenequinone with malonic acid in ethanol in the presence of ammonia. Our efforts to repeat their result gave only impure polymeric material and it seems unlikely, therefore, that their product was simply the geometric isomer of our acid.

Use of malonic acid derivatives for the construction of substituted side chains in the position 17β of steroids

1982 ◽  
Vol 47 (4) ◽  
pp. 1240-1251 ◽  
Author(s):  
Pavel Drašar ◽  
Vladimír Pouzar ◽  
Ivan Černý ◽  
Miroslav Havel ◽  
Sofia N. Ananchenko ◽  
...  
Keyword(s):  
Malonic Acid ◽  
Ethyl Cyanoacetate ◽  
Diethyl Malonate ◽  
Side Chain ◽  
Knoevenagel Reaction ◽  
Side Chains ◽  
Condensation Products ◽  
Malonic Acid Derivatives ◽  
Derivatives Of ◽  
Dioxane Ring

Using the Knoevenagel reaction condensation products of 3β-acetoxyandrost-5-en-17-one with diethyl malonate, ethyl cyanoacetate and malononitrile were prepared which converted to derivatives of 3β-hydroxypregn-5-en-21-oic acid. Reductions and oxidations of the double bonds in the positions 5,6 and 17,20 and the stereochemistry at atoms C(17) and C(20) of some derivatives were also investigated. From derivatives of 23,24-dinorchola-5,17(20)-diene-21,22-diol compounds with a 1,3-dioxane ring in the side chain were prepared.

Reactions of 3-cyano-1-methylquinolinium methyl sulphate with some C-acids and with p-nitroaniline

1981 ◽  
Vol 46 (2) ◽  
pp. 503-505 ◽  
Author(s):  
Oldřich Kocián ◽  
Miloslav Ferles
Keyword(s):  
Sodium Methoxide ◽  
Ethyl Cyanoacetate ◽  
Derivatives Of

The action of malononitrile, ethyl cyanoacetate, dibenzoylmethane and/or p-nitroaniline on compound I in the presence of sodium methoxide gives rise to derivatives of 3-cyano-1-methyl-1,4-dihydroquinoline, II and III

ChemInform Abstract: Reaction of 3-Methyleneisocamphanone with Derivatives of Malonic Acid.

ChemInform ◽  
2010 ◽  
Vol 32 (51) ◽  
pp. no-no
Author(s):  
S. S. Koval'skaya ◽  
N. G. Kozlov
Keyword(s):  
Malonic Acid ◽  
Derivatives Of

Word problems related to derivatives of the displacement map

1991 ◽  
Vol 110 (3) ◽  
pp. 569-579 ◽  
Author(s):  
J. Devlin
Keyword(s):  
Periodic Solutions ◽  
Word Problem ◽  
Word Problems ◽  
Abstract Word ◽  
Local Problem ◽  
Image Position ◽  
Derivatives Of

In [6], we considered the equationwhere z ∈ ℂ and the pi are real-valued functions; abstract word-problem concepts and techniques were applied to the local problem of the bifurcation of periodic solutions out of the solution Z ≡ 0. This paper is a sequel to [6]; we present an extension of certain concepts given in that paper, and give a global version of some of our word-problem results.

scholarly journals On a Set of Conform-Invariant Equations of the Gravitational Field

1953 ◽  
Vol 10 (1) ◽  
pp. 16-20 ◽  
Author(s):  
H. A. Buchdahl
Keyword(s):  
Gravitational Field ◽  
Linear Combination ◽  
Curvature Tensor ◽  
Wide Class ◽  
Ricci Tensor ◽  
Empty Space ◽  
Image Position ◽  
Derivatives Of

Eddington has considered equations of the gravitational field in empty space which are of the fourth differential order, viz. the sets of equations which express the vanishing of the Hamiltonian derivatives of certain fundamental invariants. The author has shown that a wide class of such equations are satisfied by any solution of the equationswhere Gμν and gμν are the components of the Ricci tensor and the metrical tensor respectively, whilst λ is an arbitrary constant. For a V4 this applies in particular when the invariant referred to above is chosen from the setwhere Bμνσρ is the covariant curvature tensor. K3 has been included since, according to a result due to Lanczos3, its Hamiltonian derivative is a linear combination of and , i.e. of the Hamiltonian derivatives of K1 and K2. In fact

A Note on a Comparison Result for Elliptic Equations

1977 ◽  
Vol 29 (5) ◽  
pp. 1081-1085 ◽  
Author(s):  
W. Allegretto
Keyword(s):  
Bounded Domain ◽  
Positive Solutions ◽  
Comparison Theorem ◽  
Elliptic Equations ◽  
Comparison Result ◽  
Mixed Derivatives ◽  
Image Position ◽  
Derivatives Of

In a recent paper [2], Bushard established and applied a comparison theorem for positive solutions to the equation:in an arbitrary bounded domain D of Euclidean w-space Rn. The proof of these results depended on the absence of mixed derivatives of u in the equation considered.

ÉTUDES SUR LA SYNTHÈSE DE L’HYDROXYPROLINE À PARTIR DE DÉRIVÉS DE L’ACIDE 2-AMINO-4-PENTÈNOÏQUE

1956 ◽  
Vol 34 (4) ◽  
pp. 502-514 ◽  
Author(s):  
Roger Gaudry ◽  
Louis Berlinguet ◽  
André Langis ◽  
Gérard Paris
Keyword(s):  
Double Bond ◽  
Acid Hydrolysis ◽  
Malonic Acid ◽  
Systematic Investigation ◽  
Carboxyl Group ◽  
Reaction Products ◽  
Pentanoic Acid ◽  
Copper Salts ◽  
Halogenation Reaction ◽  
Derivatives Of

A systematic investigation of the synthesis of 4-hydroxy-DL-proline and 2-amino-4-dihydroxyvaleric acid has been made, starting from the following derivatives of 2-amino-4-pentenoic acid: ethyl allylacetamidomalonate, ethyl allylacetamidocyanoacetate, 2-phthalimidopentenoic acid, allylacetamido-malonic acid, acetylallylglycine, 5-allylhydantoin, and 3-phenyl-5-allylhydantoin. Chlorine or bromine was added to the double bond of these compounds, and the reaction products were either derivatives of 5-halogenated-4-valerolactones or derivatives of 4,5-dihalogenated pentanoic acids, depending on whether the carboxyl group of the pentanoic acid was free or not when the halogenation reaction was carried out. Acid hydrolysis followed by treatment with barium hydroxide always gave mixtures, in different ratio, of 4-hydroxy-DL-proline and 2-amino-4,5-dihydroxyvaleric acid which were analyzed and isolated as the copper salts. In the case of 5-(2,3-dibromopropyl)hydantoin and 3-phenyl-5-(2,3-dibromopropyl)hydantoin, no cyclization could be obtained.

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