Synthesis of Bis-Amide and Hydrazide Containing Derivatives of Malonic Acid and Thiophenoladducts of Acidhydrazones Derived from 2-[(N-acetyl) 2, 5-dichloroanilido] Acetohydrazide

2011 ◽  
Vol 4 (1) ◽  
pp. 53-60
Author(s):  
Raj Narayan Sharma ◽  
K.P. Sharma ◽  
S.N. Dikshit
Keyword(s):  
Malonic Acid ◽  
Derivatives Of

ChemInform Abstract: Reaction of 3-Methyleneisocamphanone with Derivatives of Malonic Acid.

ChemInform ◽  
2010 ◽  
Vol 32 (51) ◽  
pp. no-no
Author(s):  
S. S. Koval'skaya ◽  
N. G. Kozlov
Keyword(s):  
Malonic Acid ◽  
Derivatives Of

ÉTUDES SUR LA SYNTHÈSE DE L’HYDROXYPROLINE À PARTIR DE DÉRIVÉS DE L’ACIDE 2-AMINO-4-PENTÈNOÏQUE

1956 ◽  
Vol 34 (4) ◽  
pp. 502-514 ◽  
Author(s):  
Roger Gaudry ◽  
Louis Berlinguet ◽  
André Langis ◽  
Gérard Paris
Keyword(s):  
Double Bond ◽  
Acid Hydrolysis ◽  
Malonic Acid ◽  
Systematic Investigation ◽  
Carboxyl Group ◽  
Reaction Products ◽  
Pentanoic Acid ◽  
Copper Salts ◽  
Halogenation Reaction ◽  
Derivatives Of

A systematic investigation of the synthesis of 4-hydroxy-DL-proline and 2-amino-4-dihydroxyvaleric acid has been made, starting from the following derivatives of 2-amino-4-pentenoic acid: ethyl allylacetamidomalonate, ethyl allylacetamidocyanoacetate, 2-phthalimidopentenoic acid, allylacetamido-malonic acid, acetylallylglycine, 5-allylhydantoin, and 3-phenyl-5-allylhydantoin. Chlorine or bromine was added to the double bond of these compounds, and the reaction products were either derivatives of 5-halogenated-4-valerolactones or derivatives of 4,5-dihalogenated pentanoic acids, depending on whether the carboxyl group of the pentanoic acid was free or not when the halogenation reaction was carried out. Acid hydrolysis followed by treatment with barium hydroxide always gave mixtures, in different ratio, of 4-hydroxy-DL-proline and 2-amino-4,5-dihydroxyvaleric acid which were analyzed and isolated as the copper salts. In the case of 5-(2,3-dibromopropyl)hydantoin and 3-phenyl-5-(2,3-dibromopropyl)hydantoin, no cyclization could be obtained.

scholarly journals Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors

Molecules ◽  
2008 ◽  
Vol 13 (10) ◽  
pp. 2442-2461 ◽  
Author(s):  
Mario Sechi ◽  
Ugo Azzena ◽  
Maria Paola Delussu ◽  
Roberto Dallocchio ◽  
Alessandro Dessì ◽  
...  
Keyword(s):  
Malonic Acid ◽  
Integrase Inhibitors ◽  
Design And Synthesis ◽  
Derivatives Of ◽  
Hiv 1

Derivatives of malonic acid in Parentucellia latifolia

1989 ◽  
Vol 28 (2) ◽  
pp. 651-653 ◽  
Author(s):  
J.G. Urones ◽  
I.S. Marcos ◽  
L. Cubillo ◽  
V.A. Monje ◽  
J.M. Hernández ◽  
...  
Keyword(s):  
Malonic Acid ◽  
Derivatives Of

Enamine Derivatives of Malonic Acid with Pharmacologic Activities

1964 ◽  
Vol 7 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Arthur A. Santilli ◽  
William F. Bruce ◽  
T. S. Osdene
Keyword(s):  
Malonic Acid ◽  
Derivatives Of

ChemInform Abstract: Conjugate Addition of 2-(Bromozincmethyl)-3-phenoxy-1-propene to Derivatives of Methylene Malonic Acid. Further Conversion to Methylenecyclopentanes.

ChemInform ◽  
2010 ◽  
Vol 23 (35) ◽  
pp. no-no
Author(s):  
T. A. J. VAN DER HEIDE ◽  
J. L. VAN DER BAAN ◽  
F. BICKELHAUPT ◽  
G. W. KLUMPP
Keyword(s):  
Malonic Acid ◽  
Conjugate Addition ◽  
Derivatives Of

23.—The Synthesis of Derivatives of Acenaphthenone

1974 ◽  
Vol 71 (4) ◽  
pp. 279-283 ◽  
Author(s):  
Michael J. Bedford ◽  
Douglas A. Crombie
Keyword(s):  
Polymeric Material ◽  
Malonic Acid ◽  
Hydroxy Acid ◽  
Ethyl Cyanoacetate ◽  
Geometric Isomer ◽  
Unsaturated Ester ◽  
Image Position ◽  
Derivatives Of

Acenaphthenequinone (I) condensed with ethyl cyanoacetate in ethanol to give the unsaturated ester (IIIb) while condensation with malonic acid in toluene in the presence of diethylamine gave the hydroxy acid (IIa). Esterification of this acid gave an ester (IIb) which could also be obtained by condensation of acenaphthenequinonewith ethyl hydrogen malonate. The acid (IIa) on dehydration gave 2-oxo-Δ1,α-acenaphtheneacetic acid (IIIa) of m.p. 230°C. This result seems to be in conflict with that of Rodionov and Federova (1950) who reported a m.p. of 160° for the acid (IIIa) which they obtained directly by condensation of acenaphthenequinone with malonic acid in ethanol in the presence of ammonia. Our efforts to repeat their result gave only impure polymeric material and it seems unlikely, therefore, that their product was simply the geometric isomer of our acid.

Determination of acids and their strength in isobutyl methyl ketone

1982 ◽  
Vol 47 (4) ◽  
pp. 1203-1215 ◽  
Author(s):  
Vladimír Dostál ◽  
Zdeněk Stránský ◽  
Jan Slouka
Keyword(s):  
Potentiometric Titration ◽  
Malonic Acid ◽  
Methyl Ketone ◽  
Dissociation Constants ◽  
Weak Acids ◽  
Titration Curves ◽  
Derivatives Of

The dissociation constants of nitrophenoxazines in isobutyl methyl ketone (MIBK) were determined and correlated with the HNP values in acetone. Of the derivatives studied, the strongest acid is 1,3,7-trinitrophenoxazine (pK = 19.8), the weakest, 1-nitrophenoxazine (pK > 26). The compounds have no tendency to homo- or heteroconjugation, and were used as indicators in determination of weak acids in MIBK. Some derivatives of malonic acid and of 1,2,4-triazine as well as the intermediates used in their synthesis were determined; their HNP and pK values were established. The shape of the potentiometric titration curves can be of assistance in solving some structure problems.

Sign in / Sign up

Export Citation Format

Share Document