Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty

2006 ◽  
Vol 23 (9) ◽  
pp. 748-754 ◽  
Author(s):  
B. D. Manoir ◽  
P. Bourget ◽  
M. Langlois ◽  
B. Szekely ◽  
M. Fischler ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ting Zheng ◽  
Bin Hu ◽  
Chun-ying Zheng ◽  
Feng-yi Huang ◽  
Fei Gao ◽  
...  

An amendment to this paper has been published and can be accessed via the original article.


2003 ◽  
Vol 98 (4) ◽  
pp. 950-956 ◽  
Author(s):  
T. Philip Malan ◽  
Gregory Marsh ◽  
Sam I. Hakki ◽  
Evie Grossman ◽  
Louise Traylor ◽  
...  

Background This study examined the opioid-sparing effectiveness, analgesic efficacy, and tolerability of postoperative administration of the parenteral cyclooxygenase 2 selective inhibitor, parecoxib sodium, in total hip arthroplasty patients. Methods This was a multicenter, multiple-dose, randomized, double-blind, placebo-controlled study to compare the opioid-sparing effects, analgesic efficacy, and tolerability of postoperative 20 and 40 mg intravenous parecoxib sodium with placebo in hip arthroplasty patients. The first dose of study medication was administered after surgery with an intravenous bolus dose of 4 mg morphine when patients first requested pain medication; remedication with the study medication occurred at 12 and 24 h. Subsequent morphine doses (1-2 mg) were administered by patient-controlled analgesia. Efficacy was assessed by total morphine used, pain relief and pain intensity, time to last dose of morphine, and Global Evaluation rating of the study medication. Results Parecoxib sodium, 20 and 40 mg, reduced the total amount of morphine required over 36 h by 22.1% (56.5 mg morphine) and 40.5% (43.1 mg morphine), respectively, compared with placebo (72.5 mg morphine; P < 0.01). Patients receiving 20 and 40 mg parecoxib sodium experienced significantly greater maximum pain relief compared with those in the placebo group (P < 0.05). Patients who received 20 and 40 mg parecoxib sodium discontinued PCA morphine earlier than patients receiving placebo and had significantly higher Global Evaluation ratings. Parecoxib sodium, 40 mg, plus morphine demonstrated a significantly lower incidence of fever and vomiting compared with placebo plus morphine. Conclusions Administration of parecoxib sodium with PCA morphine resulted in significantly improved postoperative analgesic management as defined by reduction in opioid requirement, lower pain scores, reduced time on PCA morphine, and higher Global Evaluation ratings.


2017 ◽  
Vol Volume 10 ◽  
pp. 1027-1032 ◽  
Author(s):  
Bogumił Olczak ◽  
Grzegorz Kowalski ◽  
Wojciech Leppert ◽  
Iwona Zaporowska-Stachowiak ◽  
Katarzyna Wieczorowska-Tobis

2017 ◽  
Vol Volume 10 ◽  
pp. 2303-2309 ◽  
Author(s):  
Bogumił Olczak ◽  
Grzegorz Kowalski ◽  
Wojciech Leppert ◽  
Agnieszka Bienert ◽  
Artur Teżyk ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ting Zheng ◽  
Bin Hu ◽  
Chun-ying Zheng ◽  
Feng-yi Huang ◽  
Fei Gao ◽  
...  

Abstract Background Fascia iliaca compartment block (FICB) is an anterior approach to the lumbar plexus block and provides the effective adjunctive analgesia for total hip arthroplasty (THA). Methods As a case series study, 28 patients (≥ 65 years old) with THA were received a modified in-plane ultrasound-guided supra-inguinal (S-FICB) as an analgesic adjunct to evaluate the analgesic effectiveness and the local anesthetic diffusion with magnetic resonance imaging (MRI). A combination of propofol and sufentanil was administered to conduct target-controlled infusion. Results The pain scores were 1 (0–4), 2 (1–5), 3 (1–6) and 3 (1–6) at 4, 8, 12, and 24 h. The cumulative opioids were 8 (8–12), 18 (16–32), 28 (24–54) and 66 (48–104) mg of i.v. morphine equivalents at 4, 8, 12, and 24 h. The patient-controlled analgesia (PCA) times were 0 (0–1), 1 (0–2), 2 (0–5) and 5 (3–8) at 4, 8, 12, and 24 h. In lateral, anterior and medial part of thigh, the sensory blockade in 28 patients was 23 (82 %), 21 (75 %) and 19 (68 %) at 5 min; 28 (100 %) at 10 and 20 min. Motor blockade of femoral nerve (FN) and obturator nerve (ON) was present in 13 (46 %) and 3 (11 %) patients at 5 min, 24 (86 %) and 9 (32 %) at 10 min, 26 (93 %) and 11 (39 %) at 20 min. Injectate permeated to the FN and extended superiorly over the surface of iliac muscle (IM) and pectineus muscle (PM) in all patients. Conclusions The modified S-FICB has provided an effective postoperative analgesic adjunct after THA with the satisfactory blockade of femoral (FN), obturator (ON) and sciatic (SN) nerves, especially for ON, when compared with the existing techniques.


Sign in / Sign up

Export Citation Format

Share Document