The Structure of the Aleutian Disease Antigen

1976 ◽  
Vol 34 ◽  
pp. 302-303
Author(s):  
N.H. Sarkar ◽  
G.W. Notani ◽  
A.J. Kenyon
Keyword(s):  
Disease Virus ◽  
Average Diameter ◽  
Icosahedral Symmetry ◽  
Structural Components ◽  
Virus Structure ◽  
Ring Structures ◽  
Aleutian Disease Of Mink ◽  
Aleutian Disease Virus ◽  
Disease Antigen

Aleutian disease of mink is transmissible by cell free extracts of affected mink tissues. Two antigenic components (Ag-1 and Ag-2) have been isolated from infected mink tissues by Kenyon and his associates. The relationships of the two antigens with the structural components of the Aleutian disease virus (ADV) have not yet been established; furthermore the details of the virus structure is lacking.We have prepared antigens from liver extracts of mink infected with Connecticut as well as Canadian strain of ADV. One of the antigen prepared from Connecticut strain of ADV contained primarily ring structures (13 nm in diameter) and few particules having icosahedral symmetry (27 nm in average diameter).

scholarly journals THE PATHOGENESIS OF ALEUTIAN DISEASE OF MINK

1969 ◽  
Vol 130 (3) ◽  
pp. 575-593 ◽  
Author(s):  
David D. Porter ◽  
Austin E. Larsen ◽  
Helen G. Porter
Keyword(s):  
Disease Virus ◽  
Viral Antigen ◽  
Virus Disease ◽  
Virus Antigen ◽  
Slow Virus Disease ◽  
Infected Liver ◽  
Aleutian Disease Of Mink ◽  
Spleen And Lymph Nodes ◽  
High Virus ◽  
Aleutian Disease Virus

Mink inoculated with 1 x 105 ID50 of Aleutian disease virus revealed very high virus titers in the tissues 8–18 days later. The highest virus titers observed were 5 x 108 ID50 per g of spleen and 1 x 109 ID50 per g of liver 10 days after inoculation. Concomitant with the increase in infectious virus titers, viral antigen(s) was found in the cytoplasm of macrophages in the spleen and lymph nodes and in Kupffer cells in the liver. Antiviral antibody was assayed by indirect immunofluorescence, using sections of infected liver as the source of antigen. A few mink infected for 9 days and all those infected 10 days or more developed antibody to Aleutian disease virus antigen(s). By 60 days after infection, when hypergammaglobulinemia was marked, the mink had an exceptionally high mean antibody titer of 100,000. The pathogenesis of the glomerulonephritis of Aleutian disease is apparently related to formation of viral antigen-antibody-complement complexes which lodge in glomerular capillaries. No evidence was found that viral infection of the kidney took place, and no autoimmune responses were found. In this "slow-virus" disease the virus replicates rapidly and the morphologic and biochemical manifestations of disease are apparently due to the continuing interplay between a replicating antigen and the host immune response.

scholarly journals Eradication of Aleutian disease of mink by eliminating positive counterimmunoelectrophoresis test reactors

1978 ◽  
Vol 7 (1) ◽  
pp. 18-22
Author(s):  
H J Cho ◽  
J Greenfield
Keyword(s):  
Disease Virus ◽  
Breeding Season ◽  
Virus Antibody ◽  
Aleutian Disease Of Mink ◽  
Aleutian Disease Virus

The counterimmunoelectrophorsis test was applied on three Aleutian disease virus-infected mink ranches for the detection of specific Aleutian disease virus antibody. All mink on the ranches were tested during the pelting season and before the breeding season for 4 consecutive years. Aleutian disease has been eliminated from the three commercial mink ranches by culling out all mink that were positive for Aleutian disease virus antibody.

Temporal replication of the Pullman strain of Aleutian disease virus in royal pastel mink.

1985 ◽  
Vol 55 (3) ◽  
pp. 853-856 ◽  
Author(s):  
W J Hadlow ◽  
R E Race ◽  
R C Kennedy
Keyword(s):  
Disease Virus ◽  
Aleutian Disease Virus

Interferon response in normal and Aleutian disease virus-infected mink.

1986 ◽  
Vol 59 (2) ◽  
pp. 514-517 ◽  
Author(s):  
D L Wiedbrauk ◽  
W J Hadlow ◽  
L C Ewalt ◽  
D L Lodmell
Keyword(s):  
Disease Virus ◽  
Interferon Response ◽  
Aleutian Disease Virus

scholarly journals Detection of Aleutian Disease Virus DNA in Tissues of Naturally Infected Mink

1988 ◽  
Vol 69 (3) ◽  
pp. 705-710 ◽  
Author(s):  
L. Haas ◽  
M. Lochelt ◽  
O.-R. Kaaden
Keyword(s):  
Disease Virus ◽  
Aleutian Disease Virus

scholarly journals Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography

2008 ◽  
Vol 82 (21) ◽  
pp. 10341-10348 ◽  
Author(s):  
Alexander N. Freiberg ◽  
Michael B. Sherman ◽  
Marc C. Morais ◽  
Michael R. Holbrook ◽  
Stanley J. Watowich
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Three Dimensional ◽  
Average Diameter ◽  
Fever Virus ◽  
Icosahedral Symmetry ◽  
Valley Fever ◽  
Virus Family ◽  
Virus Surface

ABSTRACT Rift Valley fever virus (RVFV) is a member of the Bunyaviridae virus family (genus Phlebovirus) and is considered to be one of the most important pathogens in Africa, causing viral zoonoses in livestock and humans. Here, we report the characterization of the three-dimensional structural organization of RVFV vaccine strain MP-12 by cryoelectron tomography. Vitrified-hydrated virions were found to be spherical, with an average diameter of 100 nm. The virus glycoproteins formed cylindrical hollow spikes that clustered into distinct capsomeres. In contrast to previous assertions that RVFV is pleomorphic, the structure of RVFV MP-12 was found to be highly ordered. The three-dimensional map was resolved to a resolution of 6.1 nm, and capsomeres were observed to be arranged on the virus surface in an icosahedral lattice with clear T=12 quasisymmetry. All icosahedral symmetry axes were visible in self-rotation functions calculated using the Fourier transform of the RVFV MP-12 tomogram. To the best of our knowledge, a triangulation number of 12 had previously been reported only for Uukuniemi virus, a bunyavirus also within the Phlebovirus genus. The results presented in this study demonstrate that RVFV MP-12 possesses T=12 icosahedral symmetry and suggest that other members of the Phlebovirus genus, as well as of the Bunyaviridae family, may adopt icosahedral symmetry. Knowledge of the virus architecture may provide a structural template to develop vaccines and diagnostics, since no effective anti-RVFV treatments are available for human use.

Epitopic Mapping of Structural and Nonstructural Aleutian Disease Virus Proteins

Intervirology ◽  
1986 ◽  
Vol 26 (1-2) ◽  
pp. 74-84 ◽  
Author(s):  
D.K. Kierek-Jaszczuk ◽  
W. Moennig ◽  
B. Stoke ◽  
R. Neth ◽  
S. Tan ◽  
...  
Keyword(s):  
Disease Virus ◽  
Aleutian Disease Virus ◽  
Virus Proteins
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