Developing A Supply Chain Of Apple Processed Product Traceability Information System Based On Smart Packaging And Digital Business Ecosystems

Apples are one of the fruits that much post-harvest processing can do. Apples can be processed into drinks or snacks. The need for information about nutritional content is needed by consumers. Therefore, a traceability information system is needed that can enable consumers to know the nutritional content involved. This research uses the Waterfall model information system development method and the Unified modeling language (UML). This method allows for the sequential development of information systems. The results of this research will be in the form of an information system that has been tested using the Requirement Traceability Matrix (RTM) and Response for a Class (RFC) method. The resulting Response for a Class (RFC) value is 5.17, meaning that this information system will be easy to adapt later

Postural tremor in children with motor development disorders in their first twelve months of life

At the first year of a child’s life begins a gradual transition to verticalization through the sequential development of anti-gravity postures. During the maintain of these poses occurs the active muscle contraction and appears a postural tremor.Purpose: To identify the features of postural tremor while holding the first antigravity postures in children with motor development disorders and to develop a new method for its diagnosing in children in the first six months of life. During the first year of life, the child gradually moves to verticalization through the sequential development of anti-gravity postures. To maintain these postures, the child actively contracts muscles, causing postural tremor.Objective. To reveal the features of postural tremor while holding the first antigravity postures in children with motor development disorders and to develop a new diagnostic method in the first six months of life. Children characteristics and research methods. The authors examined 33 children with impaired motor development and 10 children without neurological pathology at the age of 3–5 months. All children underwent neurological examination and study of postural tremor according to our method.Results. The authors established the features of postural tremor in children with impaired motor development at the age of 3-5 months compared with healthy children, manifested in amplitude increase. The authors presented their own for recording postural tremor in children of the first six months of life at the stage of mastering the first antigravity postures. There are presented the results of the analysis postural tremor in children of 3-5 months with impaired motor development in comparison with healthy children. The article presents a new method for diagnosing impaired motor development in children of the first six months of life using the results of postural tremor research. The high diagnostic value of the developed method is shown

Sequential Development of JAK2V617F Mutation and BCR-ABL1 Fusion in Individual Patients With Myeloproliferative Neoplasms: A Linear Clonal Evolution or Parallel Clonal Competition?

Context.— Concomitant BCR-ABL1 and JAK2V617F in myeloproliferative neoplasms (MPNs) is rare, and its pathogenesis and clinical significance are unclear. Objective.— To investigate the clonal relationship between the 2 genomic alterations, as well as the clinicopathologic impact. Design.— Retrospective analysis of MPNs with sequential development of BCR-ABL1 and JAK2V617F. Results.— Of 6 cases, 5 had JAK2V617F-positive MPN diagnosed before acquiring BCR-ABL1 years later, and 1 had BCR-ABL1+ chronic myeloid leukemia before JAK2V617F-positive myelofibrosis completely replaced the BCR-ABL1+ clone 1 year after tyrosine kinase inhibitor therapy. Among the former group, treatment for the initial MPN involved hydroxyurea, ruxolitinib, and/or supportive care, and the latency to the development of JAK2V617F ranged from 4 to 13 years (median of 9 years). Four cases showed retention of JAK2V617F, whereas BCR-ABL1 emerged as the major clone, including 2 that exhibited parallel increases in JAK2V617F and BCR-ABL1 burdens, with both genomic markers exceeding 50%. Three patients received stem cell transplants and demonstrated sustained engraftment, with the genomic markers below detectable levels. Conclusions.— Most MPNs with concomitant JAK2V617F and BCR-ABL1 are actually composite MPNs with a “second hit” residing on a different clone. Rare cases demonstrate a subclone harboring a “double-hit” in a background of a JAK2V617F-positive stem line clone. The probability of a “double-hit” with a BCR-ABL1+ stem line clone is probably reduced by effective tyrosine kinase inhibitor treatment. The treatment often involves combined kinase inhibitors and/or hydroxyurea, but the outcome is unpredictable; hematopoietic stem cell transplantation may be the ultimate therapeutic option for this complicated disease.

Psychosis in Parkinson’s Disease: Current Treatment Options and Impact on Patients and Caregivers

Parkinson’s disease (PD) is the second most common neurodegenerative disease seen in older adults after Alzheimer’s disease, with increasing prevalence worldwide. Parkinson’s disease psychosis (PDP) is a common, non-motor feature of PD, which increases caregiver stress and is a risk-factor for nursing home placement. In this paper we review PDP epidemiology, features, diagnosis, and treatment. PDP most often presents with sequential development of minor and then increasingly complex visual hallucinations mediated by dopaminergic-serotonergic interactions activating the mesolimbic pathway, with contributions from other structures and neurotransmitters. Appropriate evaluation of differential diagnoses for psychosis is vital before diagnosing PDP. Initial treatment should involve non-pharmacologic approaches. If these are unsuccessful and PDP symptoms significantly impact the patient’s and or their caregivers’ quality of life and functions, then pharmacotherapy is indicated. Pimavanserin is a recently FDA-approved pharmacologic treatment for PDP with a better profile of balanced effectiveness and safety compared to previous use of atypical antipsychotics. Early diagnosis and safer, more effective treatments for PDP should help reduce caregiver burden and enable caregivers to continue to provide care at home versus institutionalization.

Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions

Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.

The Cultural Expressions and Representation of National Identity- A Study of the Indian Singing Reality Television Show “Sa Re Ga Ma Pa”

This paper aims to understand the narrative structure of Indian singing reality television show to identify the representation of national identity. By focusing on the “Sa Re Ga Ma Pa” show format, this paper has followed the work of Vladimir Propp to examine the cultural expressions with the sequential development of the narrative plot. The convergent parallel mixed method has been using to collect quantitative and qualitative data. While using the Likert scale, the reliability of the questionnaire has been calculated and reported Cronbach’s alpha coefficient for internal consistency reliability. The quantitative data has gathered from 205 respondents and 99 episodes aired from 2017 to 2019 have analysed in qualitative data, which is followed by data analysis through IBM SPSS Statistics. By analysing the quantitative and qualitative data this paper finds that the cultural expressions reveal the notion of national identity through the representation of ‘ordinary’ people and emphasis on performances by focusing on the structured format of Indian reality television. The paper indicates the ways where the viewers of the society can connect with cultural expressions through the genre of reality television.