Neurogenesis in the visual system of embryonic and adult zebrafish (Danio rerio)

1999 ◽  
Vol 16 (3) ◽  
pp. 417-424 ◽  
Author(s):  
RIVA C. MARCUS ◽  
CATHERINE L. DELANEY ◽  
STEPHEN S. EASTER
Keyword(s):  
Danio Rerio ◽  
Optic Tectum ◽  
Nervous Tissue ◽  
General Interest ◽  
Central Position ◽  
Vertebrate Development ◽  
Adult Zebrafish ◽  
Thymidine Analog ◽  
Retinal Growth ◽  
Central Nervous Systems

The zebrafish has recently assumed a central position in the study of vertebrate development. Numerous studies of other fish have shown that their central nervous systems, and especially their visual systems, continue to add new neurons throughout life, which is probably related to their abilities to regenerate axons and whole nervous tissue. Retinal neurogenesis had not been examined in adult zebrafish, and two reports concluded that the optic tectum ceased neurogenesis early in life, so the question arose whether the zebrafish was anomalous in this regard. We labeled embryonic (24- and 48-h postfertilization) and adult zebrafish with the thymidine analog, bromo-deoxyuridine, and, after short and long survivals, examined the retina and brain for labeled cells. They were abundant in both the optic tectum and the retina. Although the rate of retinal growth slows considerably between embryonic and adult stages, the patterns of neurogenesis in both the embryo and the adult are similar to those described in other fish, so these “fish-specific” features of general interest can justifiably be studied in zebrafish.

Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish,Danio rerio, using transgenics to visualize raphe-specificpet1expression

2009 ◽  
Vol 512 (2) ◽  
pp. 158-182 ◽  
Author(s):  
Christina Lillesaar ◽  
Christian Stigloher ◽  
Birgit Tannhäuser ◽  
Mario F. Wullimann ◽  
Laure Bally-Cuif
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Serotonergic Neurons ◽  
Axonal Projections

scholarly journals Different action mechanisms of low- and high-level quercetin in the brains of adult zebrafish (Danio rerio)

2021 ◽  
Vol 223 ◽  
pp. 112597
Author(s):  
Xia Wu ◽  
Li-Jun Wang ◽  
Yu Hou ◽  
Rui-Ying Guo ◽  
Min Liu ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Action Mechanisms ◽  
High Level

scholarly journals Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 637
Author(s):  
Nicholas S. Moore ◽  
Robert A. Mans ◽  
Mackenzee K. McCauley ◽  
Colton S. Allgood ◽  
Keri A. Barksdale
Keyword(s):  
Optic Tectum ◽  
Visual Processing ◽  
Environmental Enrichment ◽  
Glycogen Synthase ◽  
Light Exposure ◽  
Hsp70 Expression ◽  
Light Cycle ◽  
Adult Zebrafish ◽  
Sleep State ◽  
Zebrafish Brain

Evidence from human and animal studies indicate that disrupted light cycles leads to alterations of the sleep state, poor cognition, and the risk of developing neuroinflammatory and generalized health disorders. Zebrafish exhibit a diurnal circadian rhythm and are an increasingly popular model in studies of neurophysiology and neuropathophysiology. Here, we investigate the effect of alterations in light cycle on the adult zebrafish brain: we measured the effect of altered, unpredictable light exposure in adult zebrafish telencephalon, homologous to mammalian hippocampus, and the optic tectum, a significant visual processing center with extensive telencephalon connections. The expression of heat shock protein-70 (HSP70), an important cell stress mediator, was significantly decreased in optic tectum of adult zebrafish brain following four days of altered light exposure. Further, pSer473-Akt (protein kinase B) was significantly reduced in telencephalon following light cycle alteration, and pSer9-GSK3β (glycogen synthase kinase-3β) was significantly reduced in both the telencephalon and optic tectum of light-altered fish. Animals exposed to five minutes of environmental enrichment showed significant increase in pSer473Akt, which was significantly attenuated by four days of altered light exposure. These data show for the first time that unpredictable light exposure alters HSP70 expression and dysregulates Akt-GSK3β signaling in the adult zebrafish brain.

scholarly journals Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure

2009 ◽  
Vol 337 (1) ◽  
pp. 45-61 ◽  
Author(s):  
Marie-Claude Senut ◽  
Seema Azher ◽  
Frank L. Margolis ◽  
Kamakshi Patel ◽  
Ahmad Mousa ◽  
...  
Keyword(s):  
Nervous System ◽  
Danio Rerio ◽  
Adult Zebrafish

scholarly journals Adaptation-induced modification of motion selectivity tuning in visual tectal neurons of adult zebrafish

2015 ◽  
Vol 114 (5) ◽  
pp. 2893-2902 ◽  
Author(s):  
Vanessa Hollmann ◽  
Valerie Lucks ◽  
Rafael Kurtz ◽  
Jacob Engelmann
Keyword(s):  
Optic Tectum ◽  
Brain Area ◽  
Direction Selectivity ◽  
Adult Brain ◽  
Orientation Tuning ◽  
Adult Zebrafish ◽  
Short Term ◽  
Short Term Plasticity ◽  
The Difference ◽  
Tectal Neurons

In the developing brain, training-induced emergence of direction selectivity and plasticity of orientation tuning appear to be widespread phenomena. These are found in the visual pathway across different classes of vertebrates. Moreover, short-term plasticity of orientation tuning in the adult brain has been demonstrated in several species of mammals. However, it is unclear whether neuronal orientation and direction selectivity in nonmammalian species remains modifiable through short-term plasticity in the fully developed brain. To address this question, we analyzed motion tuning of neurons in the optic tectum of adult zebrafish by calcium imaging. In total, orientation and direction selectivity was enhanced by adaptation, responses of previously orientation-selective neurons were sharpened, and even adaptation-induced emergence of selectivity in previously nonselective neurons was observed in some cases. The different observed effects are mainly based on the relative distance between the previously preferred and the adaptation direction. In those neurons in which a shift of the preferred orientation or direction was induced by adaptation, repulsive shifts (i.e., away from the adapter) were more prevalent than attractive shifts. A further novel finding for visually induced adaptation that emerged from our study was that repulsive and attractive shifts can occur within one brain area, even with uniform stimuli. The type of shift being induced also depends on the difference between the adapting and the initially preferred stimulus direction. Our data indicate that, even within the fully developed optic tectum, short-term plasticity might have an important role in adjusting neuronal tuning functions to current stimulus conditions.

scholarly journals Evaluation of non‐clinical safety of Frutalin in adult Zebrafish ( Danio rerio )

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Ana Cristina Oliveira Monteiro‐Moreira ◽  
Antônio Eufrásio Vieira‐Neto ◽  
Maria Kueirislene Amâncio Ferreira ◽  
Francisco Rogênio Silva Mendes ◽  
Adriana Rolim Campos Barros ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Clinical Safety
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