Azathioprine in Myeloproliferative and Autoimmune Disorders

1968 ◽  
Vol 17 (1) ◽  
pp. 258-269
Author(s):  
D. Taglioretti ◽  
A. Giangrande
Keyword(s):  
Haemolytic Anaemia ◽  
Acute Leukaemia ◽  
Clinical Results ◽  
Similar Group ◽  
Systemic Lupus ◽  
Results Of Treatment ◽  
Chronic Myelocytic Leukaemia ◽  
Myelocytic Leukaemia ◽  
Haematological Remission ◽  
Autoimmune Pathogenesis

SummaryThe report presents the clinical results of treatment with Azathioprine 6 [(methyl-4-nitro-5-imidazolyl) thio] purine, in patients with acute leukaemia, the acute relapsing phase of chronic myelocytic leukaemia and in a group of patients affected by illness which have probably an autoimmune pathogenesis.Favorable results were obtained in the group of patients suffering from acute leukaemia with a percentage of clinical and/or haematological remission of 57%.A comparative analysis of the length of survival in these patients compared to that of a similar group of patients treated with 6-mercaptopurine is also reported.A fair response was also obtained in the group of patients in the acute relapsing phase of C.M.L.In the group of patients affected by diseases probably due to an immune pathogenesis, a favorable response was obtained in 2 cases of systemic lupus erithematosus with haemolytic anaemia and 1 case of acquired autoimmune haemolytic anaemia.

Matrixplasty for the Treatment of Severe Incurved Toenail with Growth Plate Deformity

2012 ◽  
Vol 102 (3) ◽  
pp. 198-204
Author(s):  
J.-Young Kim
Keyword(s):  
Growth Plate ◽  
Clinical Results ◽  
New Technique ◽  
Partial Removal ◽  
Edge Angle ◽  
Results Of Treatment ◽  
The Mean ◽  
A New Technique ◽  
Ingrown Toenails

Background: Severely incurved toenails are accompanied by deformity of the toenail growth plate. In such a condition, partial removal of the nail and nail bed and simple unfolding of the nail itself frequently result in the recurrence of symptoms. We sought to design and develop a new technique for the treatment of incurved toenail with growth plate deformity and to report the results of treating this disease entity. Methods: Forty consecutive patients (52 cases) underwent treatment of symptomatic incurved toenails with a new technique named matrixplasty. The mean ± SD patient age was 40.3 ± 18.9 years. Last follow-up was at a mean ± SD of 18.0 ± 1.3 months. An American Orthopedic Foot and Ankle Society (AOFAS) forefoot hallux score was assigned, and patients were evaluated before treatment and at last follow-up. Patient satisfaction and the recurrence rate of the deformity were evaluated. For evaluation of improvement in toenail shape, the center to edge angle of the toenail was measured before treatment and at last follow-up. The complication rate was also evaluated. Results: All of the ingrown toenails healed, and the nail deformities were corrected within 3 weeks after the procedure. None of the incurved toenails had recurred by last follow-up. The mean pretreatment AOFAS forefoot hallux score was 72.9, and it improved to 99.6 by last follow-up (P < .001). Every patient was very satisfied or satisfied with the results of treatment. The mean ± SD center to edge angle of the toenail improved from 53.3° ± 9.5° to 15.3° ± 5.2° by last follow-up (P < .001). Minor paronychia, which was managed with local wound dressing and oral antibiotics, was identified in four cases. No other complication was identified. Conclusions: Matrixplasty showed excellent clinical results in the treatment of severe incurved toenail, and this newly developed procedure showed improvement of the deformed toenail and its growth plate. (J Am Podiatr Med Assoc 102(3): 198–204, 2012)

Cytogenetic Studies During Remission of Blastic Crisis in a Patient with Chronic Myelocytic Leukaemia

2009 ◽  
Vol 10 (2) ◽  
pp. 130-135 ◽  
Author(s):  
C. H. Srodes ◽  
E. F. Hyde ◽  
S. F. Pan ◽  
P. A. Chervenick ◽  
D. R. Boggs
Keyword(s):  
Blastic Crisis ◽  
Cytogenetic Studies ◽  
Chronic Myelocytic Leukaemia ◽  
Myelocytic Leukaemia

INTERNAL FIXATION WITH THE LOW PROFILE PLATE SYSTEM COMPARED WITH KIRSCHNER WIRE FIXATION: CLINICAL RESULTS OF TREATMENT FOR METACARPAL AND PHALANGEAL FRACTURES

Hand Surgery ◽  
2010 ◽  
Vol 15 (01) ◽  
pp. 1-6 ◽  
Author(s):  
Hidetake Takigami ◽  
Hiroaki Sakano ◽  
Tomoyuki Saito
Keyword(s):  
Kirschner Wire ◽  
Clinical Results ◽  
Delayed Union ◽  
Non Union ◽  
Results Of Treatment ◽  
Kirschner Wire Fixation ◽  
Active Flexion ◽  
Low Profile ◽  
Screw Breakage ◽  
Phalangeal Fractures

A total of 71 patients with 78 metacarpal or phalangeal fractures were treated using one of two different methods of fixation. Thirty-nine fingers were treated using a low profile plate and screw system (LPP group), whereas 39 fingers were treated using Kirschner wire (K-wire group). In the LPP group, three cases of screw breakage were recorded. The LPP group required use of a splint for 0.9 weeks, significantly less than the 4.4 weeks of the K-wire group. The mean of 2.6 ± 1.6 months for the time to union in the LPP group was significantly greater than the 1.6 ± 0.6 months in the K-wire group. There were no instances of non-union in both groups, but one delayed union was observed in the LPP group. Total active flexion was 235° and 243° in the LPP and the K-wire groups, respectively. Total extension loss was 12° and 9° in the LPP and the K-wire groups, respectively. Although use of either method resulted in a good range of motion, LPP fixation required a much shorter time with a splint. However, because of the possibility of screw breakage, we have to exercise caution with post-operative treatment.

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