scholarly journals Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression

2011 ◽  
Vol 15 (03) ◽  
pp. 375-387 ◽  
Author(s):  
Gregers Wegener ◽  
Beate C. Finger ◽  
Betina Elfving ◽  
Kirsten Keller ◽  
Nico Liebenberg ◽  
...  
Keyword(s):  
Animal Model ◽  
Neuropeptide S ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Elevated P2×7r and P2×4r transcripts levels in the Flinders Sensitive Line Rats, a genetic animal model of depression

2018 ◽  
Author(s):  
Deidiane Elisa Ribeiro ◽  
Heidi Kaastrup Müller ◽  
Betina Elfving ◽  
Samia Regiane Lourenço Joca ◽  
Gregers Wegener
Keyword(s):  
Animal Model ◽  
Stress Responses ◽  
Dorsal Hippocampus ◽  
Control Group ◽  
Protein Levels ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Sensitive Line ◽  
Stress Susceptibility ◽  
Flinders Sensitive Line

AbstractP2×7 and P2×4 receptors (P2×7R and P2×4R, respectively) are ligand-gated ion channels activated by adenosine triphosphate (ATP), which have been associated to dysfunctional processes in stress responses linked to depression, such as neurotransmitter release, cognition, sleep, energy, appetite, immune and endocrine dysfunction. Clinical studies indicate that polymorphisms in the P2×7r gene results in increased susceptibility for development of depression. Existing studies have investigated the role of P2×7R and P2×4R in animal models based on stress exposure. Therefore, the present work aimed to investigate the transcript and protein levels of these receptors in a genetic animal model of depression, the Flinders Sensitive Line (FSL) and its control group, the Flinders Resistant Line (FRL) rats. We found that FSL rats have increased transcript levels of P2×7R and P2×4R in frontal cortex (FC), ventral and dorsal hippocampus (vHip and dHip, respectively) compared to FRL rats. There were no alterations in the protein levels in the FC and dHip, but the P2×7R was lower in FSL than in FRL rats in the vHip. The results suggest that increased transcripts levels of P2×7r and P2×4r in the FSL rats may contribute to the stress-susceptibility observed in these animals.

Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression

1999 ◽  
Vol 265 (3) ◽  
pp. 191-194 ◽  
Author(s):  
Laura Caberlotto ◽  
Patricia Jimenez ◽  
David H. Overstreet ◽  
Yasmin L. Hurd ◽  
Aleksander A. Mathé ◽  
...  
Keyword(s):  
Animal Model ◽  
Neuropeptide Y ◽  
Binding Sites ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Sensitive Line ◽  
Flinders Sensitive Line
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