Analytical Characterization of Chiral Drug−Protein Interactions:  Comparison between the Optical Biosensor (Surface Plasmon Resonance) Assay and the HPLC Perturbation Method

2006 ◽  
Vol 78 (5) ◽  
pp. 1682-1689 ◽  
Author(s):  
Robert Arnell ◽  
Natalia Ferraz ◽  
Torgny Fornstedt
Keyword(s):  
Surface Plasmon Resonance ◽  
Perturbation Method ◽  
Surface Plasmon ◽  
Protein Interactions ◽  
Plasmon Resonance ◽  
Optical Biosensor ◽  
Analytical Characterization ◽  
Chiral Drug

Characterization of Surface-Confined α-Synuclein by Surface Plasmon Resonance Measurements

Langmuir ◽  
2006 ◽  
Vol 22 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Taewook Kang ◽  
Surin Hong ◽  
Hyun Jin Kim ◽  
Jungwoo Moon ◽  
Seogil Oh ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance

Development and Characterization of a Diamond-Based Localized Surface Plasmon Resonance Interface

2010 ◽  
Vol 114 (8) ◽  
pp. 3346-3353 ◽  
Author(s):  
Sabine Szunerits ◽  
Slimane Ghodbane ◽  
Joanna Niedziółka-Jönsson ◽  
Elisabeth Galopin ◽  
Frederik Klauser ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon Resonance ◽  
Localized Surface Plasmon

Characterization of labeled reagents in ligand-binding assays by a surface plasmon resonance biosensor

Bioanalysis ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 193-207 ◽  
Author(s):  
Jia Duo ◽  
JoAnne Bruno ◽  
Steven Piccoli ◽  
Binodh DeSilva ◽  
Yan J Zhang
Keyword(s):  
Surface Plasmon Resonance ◽  
Ligand Binding ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Binding Assays ◽  
Surface Plasmon Resonance Biosensor

scholarly journals Characterization of thermal bump due to surface plasmon resonance

2019 ◽  
Vol 27 (15) ◽  
pp. 21717
Author(s):  
Tsz Kit Yung ◽  
Ranran Zhang ◽  
Qiuling Zhao ◽  
Xia Wang ◽  
Wensheng Gao ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance

scholarly journals Use of a Surface Plasmon Resonance Method To Investigate Antibiotic and Plasma Protein Interactions

2009 ◽  
Vol 53 (4) ◽  
pp. 1528-1531 ◽  
Author(s):  
Françoise Banères-Roquet ◽  
Maxime Gualtieri ◽  
Philippe Villain-Guillot ◽  
Martine Pugnière ◽  
Jean-Paul Leonetti
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Protein Interactions ◽  
Plasmon Resonance ◽  
Serum Proteins ◽  
Resonance Method ◽  
Pharmacologic Effect ◽  
Nonspecific Interactions ◽  
Automatic Tool ◽  
Hit Validation

ABSTRACT The pharmacologic effect of an antibiotic is directly related to its unbound concentration at the site of infection. Most commercial antibiotics have been selected in part for their low propensity to interact with serum proteins. These nonspecific interactions are classically evaluated by measuring the MIC in the presence of serum. As higher-throughput technologies tend to lose information, surface plasmon resonance (SPR) is emerging as an informative medium-throughput technology for hit validation. Here we show that SPR is a useful automatic tool for quantification of the interaction of model antibiotics with serum proteins and that it delivers precise real-time kinetic data on this critical parameter.

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