Capillary Electrophoresis with Electrochemical Detection for Chiral Separation of Optical Isomers

1998 ◽  
Vol 70 (19) ◽  
pp. 4030-4035 ◽  
Author(s):  
Xiaoming Fang ◽  
Feiyan Gong ◽  
Yuzhi Fang
Keyword(s):  
Capillary Electrophoresis ◽  
Electrochemical Detection ◽  
Chiral Separation ◽  
Optical Isomers ◽  
Separation Of Optical Isomers

scholarly journals Chiral Selectors in Capillary Electrophoresis: Trends During 2017–2018

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1135 ◽  
Author(s):  
Raymond B. Yu ◽  
Joselito P. Quirino
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Mass ◽  
Chiral Separation ◽  
Chiral Separations ◽  
Water Soluble ◽  
Resonance Spectroscopy ◽  
Electrokinetic Chromatography ◽  
Chiral Selectors ◽  
Analytical Technique ◽  
Pharmaceutical Industries

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

Comparison of three S-β-CDs with different degrees of substitution for the chiral separation of 12 drugs in capillary electrophoresis

Chirality ◽  
2017 ◽  
Vol 29 (9) ◽  
pp. 558-565 ◽  
Author(s):  
Zhaokun Wang ◽  
Qiongwen Zhang ◽  
Linda Luo ◽  
Tiemin Sun ◽  
Xingjie Guo
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation

Determination of mannitol and three sugars in Ligustrum lucidum Ait. by capillary electrophoresis with electrochemical detection

2005 ◽  
Vol 530 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Gang Chen ◽  
Luyan Zhang ◽  
Xingliang Wu ◽  
Jiannong Ye
Keyword(s):  
Capillary Electrophoresis ◽  
Electrochemical Detection ◽  
Ligustrum Lucidum

Comparison of chiral separation of basic drugs in capillary electrophoresis and liquid chromatography using neutral and negatively charged cyclodextrins

2009 ◽  
Vol 645 (1-2) ◽  
pp. 98-104 ◽  
Author(s):  
Arkadiusz Kwaterczak ◽  
Kazimiera Duszczyk ◽  
Anna Bielejewska
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
Basic Drugs

Application of Diamond Microelectrodes for End-Column Electrochemical Detection in Capillary Electrophoresis

2003 ◽  
Vol 75 (3) ◽  
pp. 530-534 ◽  
Author(s):  
Dongchan Shin ◽  
Bulusu V. Sarada ◽  
Donald A. Tryk ◽  
Akira Fujishima ◽  
Joseph Wang
Keyword(s):  
Capillary Electrophoresis ◽  
Electrochemical Detection

Chiral separation of lobeline and benzhexol by capillary electrophoresis using the reaction mixture of β-cyclodextrin, phosphorous-pentoxide and l-glutamic acid as chiral selector

2001 ◽  
Vol 431 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Xiuli Lin ◽  
Guanbin Li ◽  
Wenqiang Jiang ◽  
Yongbao Chu ◽  
Pei Wu ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Glutamic Acid ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Phosphorous Pentoxide
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