Separation of Neutral Compounds and Basic Drugs by Capillary Electrophoresis in Acidic Solution Using Laurylpoly(oxyethylene) Sulfate as an Additive

1998 ◽  
Vol 70 (9) ◽  
pp. 1859-1865 ◽  
Author(s):  
Weiliang Ding ◽  
James S. Fritz
Keyword(s):  
Capillary Electrophoresis ◽  
Acidic Solution ◽  
Basic Drugs ◽  
Neutral Compounds

Evaluation of the enantioselectivity of glycogen-based dual chiral selector systems towards basic drugs in capillary electrophoresis

2010 ◽  
Vol 1217 (45) ◽  
pp. 7158-7163 ◽  
Author(s):  
Jiaquan Chen ◽  
Yingxiang Du ◽  
Fenxia Zhu ◽  
Bin Chen
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Basic Drugs

Gas-chromatographic determination of disopyramide in serum, with use of a nitrogen-selective detector.

1979 ◽  
Vol 25 (2) ◽  
pp. 311-313 ◽  
Author(s):  
J Vasiliades ◽  
C Owens ◽  
D Pirkle
Keyword(s):  
Gas Chromatography ◽  
Sodium Hydroxide ◽  
Standard Error ◽  
Acidic Solution ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Basic Drugs ◽  
Selective Detector ◽  
Instrument Response

Abstract In this procedure for disopyramide in serum, the drug is extracted into n-heptane/isobutanol (96/4 by vol), then back-extracted into 1 mol/L H2SO4. The acidic solution is made basic with sodium hydroxide, extracted with diethyl ether, and the extract evaporated. The residue is redissolved in ethanol and analyzed by gas-chromatography, with use of a nitrogen-selective detector. p-Chlorodisopyramide is used as internal standard. Concentration and instrument response for serum extracts are linearly related from 1 to 5 mg/L, the slope being 0.61, the y-intercept -0.10, the standard error of estimate 0.01, and the correlation coefficient 0.99. Within-run precision was 6 and 4% for 3 and 5 mg/L concentrations, respectively, with a between-run precision of 7% at the 3 mg/L concentration. Diazepam interferes, but procainamide, chlordiazepoxide, quinidine, lidocaine, propranolol, sulfanilamide, and many other basic drugs do not.

Effect of structure modification of chondroitin sulfate C on its enantioselectivity to basic drugs in capillary electrophoresis

2002 ◽  
Vol 947 (2) ◽  
pp. 287-299 ◽  
Author(s):  
Yingxiang Du ◽  
Atsushi Taga ◽  
Shigeo Suzuki ◽  
Wenying Liu ◽  
Susumu Honda
Keyword(s):  
Capillary Electrophoresis ◽  
Chondroitin Sulfate ◽  
Basic Drugs ◽  
Structure Modification ◽  
Effect Of Structure

Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis

2015 ◽  
Vol 38 (16) ◽  
pp. 2900-2906 ◽  
Author(s):  
Tao Yu ◽  
Yingxiang Du ◽  
Jiaquan Chen ◽  
Guangfu Xu ◽  
Ke Yang ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Basic Drugs
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