Conformational Stability of Adsorbed Insulin Studied with Mass Spectrometry and Hydrogen Exchange

1999 ◽  
Vol 71 (15) ◽  
pp. 3219-3225 ◽  
Author(s):  
Jos Buijs ◽  
César Costa Vera ◽  
Edy Ayala ◽  
Elles Steensma ◽  
Per Håkansson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Hydrogen Exchange ◽  
Conformational Stability

Determination of amide hydrogen exchange rates in peptides by mass spectrometry

1992 ◽  
Vol 64 (20) ◽  
pp. 2456-2458 ◽  
Author(s):  
Geraldine. Thevenon-Emeric ◽  
John. Kozlowski ◽  
Zhongqi. Zhang ◽  
David L. Smith
Keyword(s):  
Mass Spectrometry ◽  
Exchange Rates ◽  
Hydrogen Exchange ◽  
Amide Hydrogen ◽  
Amide Hydrogen Exchange

scholarly journals Solid state catalytic hydrogen exchange for deuterium in cycloprolylglycine

2019 ◽  
Vol 484 (3) ◽  
pp. 307-311
Author(s):  
A. K. Dadayan ◽  
Yu. A. Borisov ◽  
E. V. Bocharov ◽  
Yu. A. Zolotarev ◽  
I. Yu. Nagaev ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Solid State ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Density Functional ◽  
Hydrogen Exchange ◽  
Functional Theory ◽  
Catalytic Hydrogen ◽  
Spillover Hydrogen ◽  
High Stereoselectivity

The reaction of spillover hydrogen (SH) with cyclopropylglycine (cPG) in high-temperature solid-state catalytic hydrogen isotope exchange (HTCIE) has been studied experimentally and using density functional theory (DFT). NMR spectroscopy and mass spectrometry have shown a high regioselectivity and stereoselectivity for the reaction of spillover hydrogen with cPG fragments. The Gly fragment has been shown to be the most reactive in HTCIE, for which high stereoselectivity of substitution of hydrogen by deuterium has been demonstrated.

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