scholarly journals The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246–Val4270 Reveals a Fifth Calcium Binding Site

Biochemistry ◽  
2021 ◽  
Author(s):  
Qinhong Yu ◽  
David E. Anderson ◽  
Ramanjeet Kaur ◽  
Andrew J. Fisher ◽  
James B. Ames
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Calcium Binding ◽  
Calcium Binding Site ◽  
Cardiac Ryanodine Receptor

scholarly journals Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site

2011 ◽  
Vol 20 (5) ◽  
pp. 827-833 ◽  
Author(s):  
Arulandu Arockiasamy ◽  
Anup Aggarwal ◽  
Christos G. Savva ◽  
Andreas Holzenburg ◽  
James C. Sacchettini
Keyword(s):  
Crystal Structure ◽  
Mycobacterium Tuberculosis ◽  
Binding Site ◽  
Calcium Binding ◽  
Calcium Binding Site

scholarly journals Mutation Analysis of the Calcium Binding Site of Skeletal Muscle Ryanodine Receptor Calcium Release Channel

2019 ◽  
Vol 116 (3) ◽  
pp. 520a-521a
Author(s):  
Venkat R. Chirasani ◽  
Le Xu ◽  
Jordan S. Carter ◽  
Hannah G. Addis ◽  
Daniel A. Pasek ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Mutation Analysis ◽  
Calcium Binding ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Calcium Binding Site ◽  
Release Channel

scholarly journals The X-ray structure of human calbindin-D28K: an improved model

2018 ◽  
Vol 74 (10) ◽  
pp. 1008-1014 ◽  
Author(s):  
James W. Noble ◽  
Rehab Almalki ◽  
S. Mark Roe ◽  
Armin Wagner ◽  
Ramona Duman ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Calcium Binding ◽  
Tertiary Structure ◽  
Nmr Structure ◽  
Calcium Binding Site ◽  
Globular Structure ◽  
Saxs Data ◽  
X Ray ◽  
Calbindin D28k

Calbindin-D28K is a widely expressed calcium-buffering cytoplasmic protein that is involved in many physiological processes. It has been shown to interact with other proteins, suggesting a role as a calcium sensor. Many of the targets of calbindin-D28K are of therapeutic interest: for example, inositol monophosphatase, the putative target of lithium therapy in bipolar disorder. Presented here is the first crystal structure of human calbindin-D28K. There are significant deviations in the tertiary structure when compared with the NMR structure of rat calbindin-D28K (PDB entry 2g9b), despite 98% sequence identity. Small-angle X-ray scattering (SAXS) indicates that the crystal structure better predicts the properties of calbindin-D28K in solution compared with the NMR structure. Here, the first direct visualization of the calcium-binding properties of calbindin-D28K is presented. Four of the six EF-hands that make up the secondary structure of the protein contain a calcium-binding site. Two distinct conformations of the N-terminal EF-hand calcium-binding site were identified using long-wavelength calcium single-wavelength anomalous dispersion (SAD). This flexible region has previously been recognized as a protein–protein interaction interface. SAXS data collected in both the presence and absence of calcium indicate that there are no large structural differences in the globular structure of calbindin-D28K between the calcium-loaded and unloaded proteins.

scholarly journals Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations

2014 ◽  
Vol 106 (2) ◽  
pp. 108a
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin C. Carlsson ◽  
Paolo A. Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Cardiac Ryanodine Receptor

scholarly journals Cytochrome c3fromDesulfovibrio gigas: Crystal structure at 1.8 Å resolution and evidence for a specific calcium-binding site

1996 ◽  
Vol 5 (7) ◽  
pp. 1342-1354 ◽  
Author(s):  
Pedro M. Matias ◽  
José Morais ◽  
Ricardo Coelho ◽  
Maria Arménia Carrondo ◽  
Keith Wilson ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Calcium Binding ◽  
Calcium Binding Site

scholarly journals A regulatory calcium-binding site for calcium channel in isolated rat hepatocytes.

1985 ◽  
Vol 260 (6) ◽  
pp. 3289-3294
Author(s):  
J Poggioli ◽  
J P Mauger ◽  
F Guesdon ◽  
M Claret
Keyword(s):  
Calcium Channel ◽  
Binding Site ◽  
Calcium Binding ◽  
Rat Hepatocytes ◽  
Calcium Binding Site ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Crystallization of a synthetic analog of calcium-binding site III of rabbit skeletal troponin C

1989 ◽  
Vol 264 (17) ◽  
pp. 10261-10263
Author(s):  
L T J Delbaere ◽  
M Vandonselaar ◽  
R E Reid
Keyword(s):  
Binding Site ◽  
Calcium Binding ◽  
Troponin C ◽  
Synthetic Analog ◽  
Calcium Binding Site

scholarly journals A disulfide bridge in the calcium binding site of a polyester hydrolase increases its thermal stability and activity against polyethylene terephthalate

FEBS Open Bio ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Johannes Then ◽  
Ren Wei ◽  
Thorsten Oeser ◽  
André Gerdts ◽  
Juliane Schmidt ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Binding Site ◽  
Polyethylene Terephthalate ◽  
Calcium Binding ◽  
Disulfide Bridge ◽  
Calcium Binding Site
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